Results 121 to 130 of about 3,236 (190)

IL‐7R‐Enriched Extracellular Vesicles From the Thymus Drive Colitis via Promoting Neutrophil Extracellular Trap Formation

Advanced Science, Volume 13, Issue 49, 3 September 2026.
Inflammatory bowel disease (IBD) pathogenesis remains unclear. This study reveals that thymus‐originated IL‐7R‐enriched extracellular vesicles exacerbate colitis by promoting neutrophil extracellular traps via a thymus‐gut axis, uncovering an inter‐organ communication mechanism in inflammatory bowel disease pathogenesis.
Yao Liao, Yuheng Liu, Ruibing Yang, Zifeng Zhu, Junwei Wu, Dinghao Li, Jin Su, Yingxin He, Shiqi Luo, Feiyang Cao, Haiyi Deng, Lanmengxi Yang, Ling Zhong, Peiying Peng, Xinyi Wu, Chunmei Cai, Zhen Li, Yujin Wu, Shuofeng Zhu, Jie Wei, Yi Yang, Lifu Wang   +21 more
wiley   +1 more source

Eupatolide, isolated from Liriodendron tulipifera, sensitizes TNF-mediated dual modes of apoptosis and necroptosis by disrupting RIPK1 ubiquitination

Heliyon
Ubiquitination of RIPK1 plays an essential role in the recruitment of the IKK complex, an upstream component of pro-survival NF-κB. It also limits TNF-induced programmed cell death by inhibiting the spatial transition from TNFR1-associated complex-I to ...
Kyeong Ah Park, Chan Seok Jung, Kyung-Cheol Sohn, Eunjin Ju, Sanghee Shin, InWha Park, MinKyun Na, Gang Min Hur   +7 more
doaj   +1 more source

Increased Amyloidogenic Neuronal Injury in HIV‐1–infected APP‐KI Alzheimer's disease mice

Alzheimer's &Dementia, Volume 22, Issue 9, September 2026.
Abstract INTRODUCTION A higher incidence of dementia, including Alzheimer's‐like pathology, is observed in aged people living with human immunodeficiency virus‐1 (HIV‐1). However, mechanisms linking HIV‐1 to Alzheimer's disease (AD) pathology remain unclear, due to the lack of animal models that allow for concurrent studies of HIV‐1 and AD.
Shaurav Bhattarai, Emma G. Foster, Rana Kadry, Yaman Lu, Mohit Kumar, Syed Qasim, Amrita Mitra, Harsh Pathak, Larisa Y. Poluektova, Santhi Gorantla, R. Lee Mosley, Pravin Yeapuri, Howard E. Gendelman   +12 more
wiley   +1 more source

RIPK1 Distinctly Regulates Yersinia-Induced Inflammatory Cell Death, PANoptosis

, 2020
Bacterial pathogens from the genus Yersinia cause fatal sepsis and gastritis in humans. Innate immune signaling and inflammatory cell death (pyroptosis, apoptosis, and necroptosis [PANoptosis]) serve as a first line of antimicrobial host defense.
Kanneganti, Thirumala-Devi, Burton, Amanda R., Kancharana, Balabhaskararao, Kesavardhana, Sannula, Karki, Rajendra, Subbarao, Malireddi R.K.   +5 more
core   +1 more source

Melatonin Protects BEAS‐2B Cells Against Hypoxia/Reoxygenation‐Induced Injury By Reducing MLKL Levels, Suppressing Oxidative Stress and Preserving Mitochondrial Function

Cell Biochemistry and Function, Volume 44, Issue 9, September 2026.
ABSTRACT Necroptosis has been demonstrated to play a role in the process of lung ischemia‐reperfusion injury (LIRI) in a variety of clinical conditions, including cardiopulmonary bypass and pulmonary embolism. Melatonin has been reported to exert a protective role by reducing oxidative stress and acute inflammatory reactions in LIRI.
Zehra Yilmaz, Askin Tas, Ozlem Oz, Ismail Koyuncu, Ebru Temiz, Ozgur Yuksekdag   +5 more
wiley   +1 more source

Microglia and neuroinflammation: An in‐depth analysis from functional diversity to disease mechanisms

Clinical and Translational Medicine, Volume 16, Issue 9, September 2026.
1. Microglial functions arise from dynamic, context‐dependent programs rather than fixed M1/M2 phenotypes. 2. Inflammatory, interferon‐responsive, phagocytic/lipid‐metabolic and repair‐associated programs coexist across disease stages and brain regions. 3.
Jie Chen, Wangzheqi Zhang, Lizhou Song, Yan Liao, Haoling Zhang, Yiyang Xia, Derong Cui   +6 more
wiley   +1 more source

RIPK1 ensures intestinal homeostasis by protecting the epithelium against apoptosis

, 2014
Receptor interacting protein kinase 1 (RIPK1) has an essential role in the signalling triggered by death receptors and pattern recognition receptors(1,2).
Kourula, Stephanie, Amanda Gonçalves, Christoph Becker, Mathieu J. M. Bertrand, Duprez, Linde, van Loo, Geert, Nozomi Takahashi, Stephanie Kourula, Scott B. Berger, Tatyana Divert, Sze, Mozes, Divert, Tatyana, Claudia Günther, Wim Declercq, Lars Vereecke, Bertrand, Mathieu, Sylvie Lefebvre, Takahashi, Nozomi, Günther, Claudia, Mozes Sze, Vera Goossens, Berger, Scott B, Bertin, John, Vereecke, Lars, Declercq, Wim, Becker, Christoph, Peter J. Gough, Gough, Peter J, John Bertin, Gonçalves, Amanda, Goossens, Vera, Linde Duprez, Lefebvre, Sylvie, Vandenabeele, Peter, Barbara Gilbert, Gilbert, Barbara, Geert van Loo, Peter Vandenabeele   +37 more
core   +1 more source

Fucoxanthin Attenuates Hepatic Damage in a d‐Galactose‐Induced Accelerated Aging Mouse Model: Insight Into Underlying Mechanisms

Food Frontiers, Volume 7, Issue 5, September 2026.
Fucoxanthin alleviates d‐galactose‐induced hepatic damage by reducing oxidative stress, inflammation, and multiple programmed cell death pathways. ABSTRACT The global population is aging rapidly, and aging‐related hepatic damage poses a significant public health challenge.
Han‐Ni Wei, Cheng‐Yu Yang, Hui Li, Shi‐Xiang Wu, Qing‐Yan Zou, Yan Zheng, Kazuo Miyashita, Yu‐Hong Yang, Lei Du   +8 more
wiley   +1 more source

RIPK1 both positively and negatively regulates RIPK3 oligomerization and necroptosis

, 2014
Necroptosis is a form of programmed cell death that depends on the activation of receptor interacting protein kinase-1 (RIPK1) and RIPK3 by receptors such as tumor necrosis factor (TNF) receptor-1.
Green, D.R., Tait, S.W.G., M L Albert, Orozco, S, Green, D R, N Yatim, Werner, M R, Oberst, A, S Orozco, A Oberst, S Y Gunja, Yatim, N, S WG Tait, M R Werner, H Tran, Werner, M.R., Gunja, S.Y., Albert, A, Albert, M.L., Oberst, A., D R Green, Tran, H., Tran, H, Tait, S Wg, Gunja, S y   +24 more
core   +1 more source

Bioinformatics analyses reveal the role of RIPK1 in clear cell renal cell carcinoma

BMC Cancer
Background Receptor interacting protein kinase 1 (RIPK1) is crucial in the regulation of apoptosis; however, its significance in clear cell renal cell carcinoma (ccRCC) is not well understood. Methods Utilizing data collected from public databases, RIPK1
Daocheng Fang, Yuanyuan Hu, Shuangquan Sun, Hui Wen, Jie Fan   +4 more
doaj   +1 more source