Results 101 to 110 of about 18,314 (233)

Targeting the RAGE–RIPK1 binding site attenuates diabetes-associated cognitive deficits

Journal of Neuroinflammation
Microglial activation can cause neuroinflammation and the consequent neurological impairments play prominent roles in diabetes-associated cognitive deficits.
Lin Gao, Shidi Wu, Bin Hu, Qiuyu Zhang, Yifei Wu, Hui Li, Ye Qian, Chengyu Huang, Xiangru Wen, Hui Li, Aifang Cheng, Yuanjian Song, Changjiang Ying, Xiaoyan Zhou   +13 more
doaj   +1 more source

Biogenesis of TNF‐α‐insights into proteostasis and inflammation

The FEBS Journal, EarlyView.
TNF‐α biogenesis, trafficking, and signalling are tightly and reciprocally coupled to cellular proteostasis systems, including ER chaperones and endoplasmic reticulum‐associated degradation. This bidirectional crosstalk determines whether TNF‐α responses are adaptive or proteotoxic.
Bailasan Haidar, Céline Philippe, Eric Chevet, Jiří Zahradník   +3 more
wiley   +1 more source

Downregulation of Ripk1 and Nsf mediated by CRISPR-CasRx ameliorates stroke volume and neurological deficits after ischemia stroke in mice

Frontiers in Aging Neuroscience
Necroptosis is implicated in the pathogenesis of ischemic stroke. However, the mechanism underlying the sequential recruitment of receptor-interacting protein kinase 1 (RIPK1) and N-ethylmaleimide-sensitive fusion ATPase (NSF) in initiating necroptosis ...
Xincheng Song, Xincheng Song, Yang Lan, Shuang Lv, Yuye Wang, Leian Chen, Tao Lu, Fei Liu, Dantao Peng, Dantao Peng, Dantao Peng   +10 more
doaj   +1 more source

PUMA amplifies necroptosis signaling by activating cytosolic DNA sensors. [PDF]

, 2018
Necroptosis, a form of regulated necrotic cell death, is governed by RIP1/RIP3-mediated activation of MLKL. However, the signaling process leading to necroptotic death remains to be elucidated.
Chen, Dongshi, Stolz, Donna B., Tong, Jingshan, Wei, Liang, Yang, Liheng, Yu, Jian, Zhang, Jianke, Zhang, Lin   +7 more
core   +2 more sources

Arabidopsis inositol polyphosphate kinase activities regulate COP9 deneddylation functions in phosphate homeostasis

Journal of Integrative Plant Biology, EarlyView.
Plant phosphate (Pi) homeostasis relies on coordinated activities of the inositol polyphosphate kinases IPK1 and ITPK1, which balance localized InsP7 biosynthesis to control COP9 signalosome (CSN)‐dependent deneddylation of cullin 1 (CUL1). Perturbation of this equilibrium affects the stability of SPX4, a key negative regulator of phosphate starvation ...
Yashika Walia, Medha Noopur, Ishana Bhattacharya, Bhaskar Chandra Sahoo, Mritunjay Kasera, Naga Jyothi Pullagurla, Smritikana Dutta, Guizhen Liu, Gabriel Schaaf, Henning Jessen, Debabrata Laha, Souvik Bhattacharjee, Saikat Bhattacharjee   +12 more
wiley   +1 more source

Role of RIPK1/RIPK3/MLKL signalling pathway in sepsis‐associated acute kidney injury

Experimental Physiology, EarlyView.
Abstract Sepsis‐associated acute kidney injury (SA‐AKI) is a common clinical syndrome in critically ill patients, and its high mortality rate is closely related to complex pathological mechanisms. Existing studies have shown that the pathophysiological process of SA‐AKI involves complex multi‐mechanism interactions, including an uncontrolled systemic ...
Huijun Yin, Jingyi Wang, Huirong Han
wiley   +1 more source

Holding RIPK1 on the Ubiquitin Leash in TNFR1 Signaling [PDF]

, 2016
The kinase RIPK1 is an essential signaling node in various innate immune signaling pathways being most extensively studied in the TNFR1 signaling pathway.
Darding, M, Peltzer, N, Walczak, H
core  

Caspase-8 functions as a key mediator of inflammation and pro-IL-1β processing via both canonical and non-canonical pathways. [PDF]

, 2015
Caspase-8 is an apical component of cell death pathways. Activated caspase-8 can drive classical caspase-dependent apoptosis and actively inhibits cell death mediated by RIPK3-driven necroptosis.
Bryant, Clare E, Monie, Tom P
core   +2 more sources

The mitochondrial‐targeted antioxidant SkQ1 prevents skeletal muscle mitochondrial‐apoptotic but not necroptotic signalling during ovarian cancer

The Journal of Physiology, EarlyView.
Abstract figure legend An evaluation of the degree to which mitochondrial hydrogen peroxide emission (mH2O2)‐mediated apoptotic and necroptotic signalling contributes to skeletal muscle atrophy in an orthotopic epithelial ovarian cancer (EOC) model. To determine whether attenuating mH2O2 could prevent regulated cell death signalling and mitigate muscle
Shahrzad Khajehzadehshoushtar, Luca J. Delfinis, Fasih A. Rahman, Madison C. Garibotti, Shivam Gandhi, Aditya N. Brahmbhatt, Brooke A. Morris, Bianca Garlisi, Sylvia Lauks, Caroline Aitken, Leslie Ogilvie, Zhu‐Xu Zhang, Jeremy A. Simpson, Joe Quadrilatero, Jim Petrik, Christopher G. R. Perry   +15 more
wiley   +1 more source

RIPK3 Inhibition Mitigates Denervated Muscle Atrophy via NOX4‐Mediated Mitochondrial Restoration and Inflammation Suppression

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 3, June 2026.
ABSTRACT Background Peripheral nerve injury‐induced muscle atrophy shares core pathophysiological features with systemic wasting disorders including cachexia and sarcopenia, yet early molecular triggers remain undefined. This study investigates the pathogenic role of receptor‐interacting protein kinase 3 (RIPK3) in denervation atrophy.
Yuntian Shen, Chen Zhang, Zihao Zhao, Jia Yi, Xinlei Yao, Bingqian Chen, Hualin Sun   +6 more
wiley   +1 more source