Results 101 to 110 of about 3,236 (190)

Effects of paraprobiotic Lactobacillus acidophilus LA‐5 on PANoptosis, oxidative stress and inflammation in acetic acid‐induced ulcerative colitis

Journal of the Science of Food and Agriculture, EarlyView.
Abstract BACKGROUND Ulcerative colitis (UC) is a relapsing inflammatory bowel disease characterised by oxidative stress, inflammation and regulated cell death of the colonic mucosa. Because live probiotics may cause bacteraemia and sepsis in immunocompromised hosts, non‐viable (paraprobiotic) alternatives have attracted interest.
Adem Yavaş, Ezgi Özkıran, Ecem Akan
wiley   +1 more source

Exploring the role of RIPK1 in T cell homeostasis

, 2023
Tijdens dit doctoraatsonderzoek werd de rol van het receptor-interagerend proteïne kinase 1 (RIPK1) onderzocht in T lymfocyten, gespecialiseerde cellen die een cruciale rol spelen in ons immuunsysteem.
Huysentruyt, Jelle
core  

Toward Predicting Pandemic Potential: A Comparative Analysis of Virus‐Host Interactions Between Diverse Influenza A Viruses and the Human Innate Immune System

PROTEOMICS, EarlyView.
ABSTRACT Zoonotic infections caused by influenza A viruses (IAVs) of animal origin are a major public health concern, as they may represent the initial step toward the emergence of a pandemic strain. The host range of IAVs is shaped by species‐specific virus‐host interactions, and several host barriers have been identified that restrict the adaptation ...
Antoine Gerodez, Melanie Dos Santos, Mikaël Attia, Killian De Geest, Ibrahim Hamid, Rodrigue Tesse, Ilham Fdillate, Marc Boschmans, Steven Van Borm, Mieke Steensels, Benedicte Lambrecht, Lionel Tafforeau, Caroline Demeret, Cyril Barbezange   +13 more
wiley   +1 more source

RIPK1 maintains epithelial homeostasis by inhibiting apoptosis and necroptosis

, 2014
Necroptosis has emerged as an important pathway of programmed cell death in embryonic development, tissue homeostasis, immunity and inflammation. RIPK1 is implicated in inflammatory and cell death signalling and its kinase activity is believed to drive ...
Marijana Basic, Andre Bleich, Apostolos Polykratis, Eftychi, Christina, Petra Kirsch, Polykratis, Apostolos, Michelle Kelliher, Zelic, Matija, Manolis Pasparakis, Kelliher, Michelle, Chun Kim, Pasparakis, Manolis, Juan Lin, Vlantis, Katerina, Wachsmuth, Laurens, Bleich, Andre, Kirsch, Petra, Nicole Hermance, Dannappel, Marius, Snehlata Kumari, Katerina Vlantis, Kim, Chun, Lin, Juan, Teresa Corona, Kumari, Snehlata, Hermance, Nicole, Laurens Wachsmuth, Corona, Teresa, Marius Dannappel, Christina Eftychi, Matija Zelic, Basic, Marijana   +31 more
core   +1 more source

Photoactivated iridium(III) complexes drive pyroptosis–necroptosis synergy for multi‐network photoimmunotherapy of renal cell carcinoma

Smart Molecules, EarlyView.
Photoactivated iridium(III) complexes trigger mitochondrial DNA leakage and Ca²⁺ efflux, simultaneously driving pyroptosis and necroptosis to synergistically enhance immunogenic cell death. This multi‐network cascade promotes dendritic cell maturation and CD8⁺ T cell activation, achieving potent photoimmunotherapy of renal cell carcinoma.
Xin Qin, Meng‐Di Chen, Wenqi Gao, Yiping Wang, Lin‐Qing Liu, Zhen Teng, Tienan Qi, Qiyuan Wang, Yuxuan Wang, Daoxiang Li, Keqiang Yan, Ling Pan, Zhongwei Zhao, Shuo Zhao, Kang‐Nan Wang, Shuai Fu, Nengwang Yu   +16 more
wiley   +1 more source

MK2 phosphorylation of RIPK1 regulates TNF-mediated cell death

, 2017
TNF is a master proinflammatory cytokine whose pathogenic role in inflammatory disorders can, in certain conditions, be attributed to RIPK1 kinase-dependent cell death.
Diego Rojas-Rivera, Delvaeye, TinnekeUGent0000704967688020013359099757328760140000-0002-8207-1341089121FA-F0EE-11E1-A9DE-61C894A0A6B4, Dondelinger, Yves, Bruggeman, IngeWE14801001213466277853FE-F0EE-11E1-A9DE-61C894A0A6B4, Mathieu J. M. Bertrand, Dondelinger, YvesUGent00009079462680200073228397825720118226848544-F0EE-11E1-A9DE-61C894A0A6B4, Delanghe, TomWE140001106986228020024328170000-0002-6337-6457375DBF16-F0EE-11E1-A9DE-61C894A0A6B4, Van Herreweghe, Franky, Inge Bruggeman, Rojas Rivera, DiegoUGent802002227396977707496021C38DDCC2-B0DB-11E5-A24A-8CD8B4D1D7B1, Dario Priem, Bruggeman, Inge, Bertrand, MathieuWE140001614180038020005477810000-0001-9000-062601661B60-F0EE-11E1-A9DE-61C894A0A6B4, Priem, DarioWE140000900880418020019117440000-0002-2527-11011D22D0AA-F0EE-11E1-A9DE-61C894A0A6B4, Bertrand, Mathieu, Delanghe, Tom, Rojas Rivera, Diego, Vandenabeele, PeterCA05WE140019790145118010005653840000-0002-6669-8822F4243658-F0ED-11E1-A9DE-61C894A0A6B4, Yves Dondelinger, Priem, Dario, Tinneke Delvaeye, Vandenabeele, Peter, Franky Van Herreweghe, Tom Delanghe, Delvaeye, Tinneke, Van Herreweghe, Franky001992149220801001189925919016483031FA5C7364-F0ED-11E1-A9DE-61C894A0A6B4, Peter Vandenabeele   +26 more
core   +1 more source

Deciphering diverse cell‐death patterns to predict the prognosis and potential therapy target of hepatocellular carcinoma patients

VIEW, EarlyView.
Abstract Ninety percent of all primary liver malignancies are hepatocellular carcinomas (HCC), making liver cancer the third most common cause of cancer‐associated mortality. Different patterns of programmed cell death (PCD) are crucial for the survival of tumors, and they might serve as a prognostic marker for HCC.
Lin Ding, Qian Li, Wenjing Yang, Te Liu, Tongtong Tian, Yu Liu, Chunyan Zhang, Baishen Pan, Beili Wang, Fan Wu, Wei Guo   +10 more
wiley   +1 more source

The role of RIPK1 signaling in liver injury and cancer [PDF]

, 2017
The serine/threonine kinase receptor-interacting protein kinase (RIPK) 1 with pro-death kinase-dependent and pro-survival kinase-independent functions has emerged as an important regulator of cell death, survival and inflammation downstream of death ...
Van, Trieu My
core   +1 more source

Current Advances of Treatments, Therapeutic Targets, Biomarkers, Novel Drugs, and Machine Learning for Hypopharyngeal Squamous Cell Carcinoma

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Hypopharyngeal squamous cell carcinoma (HSCC) is an aggressive subtype of head and neck squamous cell carcinoma with insidious onset, early metastasis, and dismal prognosis. Conventional multimodal therapy achieves limited survival benefit, highlighting an urgent need for refined precision strategies.
Ce Li, Rui Guan, Rui‐Jie Jiao, Zhi‐Jie Bi, Yang Fu, Yin Wang, Chen‐Yang Xu, Ye Qian, Ran Wei, Sheng‐Da Cao, Wen‐Ming Li, Dong‐Min Wei, Da‐Peng Lei   +12 more
wiley   +1 more source

MyD88‐Family Adaptors: Compartmentalised Signalling and Non‐Immune Functions

Immunology, EarlyView.
MyD88‐family adaptors coordinate receptor‐ and compartment‐specific innate immune signalling across plasma membrane and endosomal pathways. At the plasma membrane, TIRAP/MAL supports MyD88‐dependent signalling downstream of TLR2 and TLR4, whereas endosomal TLR7, TLR8 and TLR9 recruit MyD88 directly.
Seshu Vardhan Pothabathula, Saurabh Mishra, Pugazhendhi Kannan, Annette Bellar, Amy Attaway, Nicole Welch, Srinivasan Dasarathy   +6 more
wiley   +1 more source