Results 101 to 110 of about 15,574 (187)

MyD88‐Family Adaptors: Compartmentalised Signalling and Non‐Immune Functions

Immunology, EarlyView.
MyD88‐family adaptors coordinate receptor‐ and compartment‐specific innate immune signalling across plasma membrane and endosomal pathways. At the plasma membrane, TIRAP/MAL supports MyD88‐dependent signalling downstream of TLR2 and TLR4, whereas endosomal TLR7, TLR8 and TLR9 recruit MyD88 directly.
Seshu Vardhan Pothabathula, Saurabh Mishra, Pugazhendhi Kannan, Annette Bellar, Amy Attaway, Nicole Welch, Srinivasan Dasarathy   +6 more
wiley   +1 more source

RIPK3 mediates RIPK1-dependent apoptosis

, 2013
peer reviewedReceptor-interacting protein kinase (RIPK) 1 and RIPK3 have emerged as essential kinases mediating a regulated form of necrosis, known as necroptosis, that can be induced by tumor necrosis factor (TNF) signaling. As a consequence, inhibiting
C Dubuisson, Aguileta, Miguel, Dejardin, E, Dubuisson, C, Grootjans, Sasker, E Dejardin, M J M Bertrand, Dondelinger, Yves, Dubuisson, Christel, Aguileta, M, Goosens, V, Vandenabeele, P, Y Dondelinger, Goossens, Vera, V Goossens, Vandenabeele, Peter, P Vandenabeele, M A Aguileta, Grootjans, S, S Grootjans, Dejardin, Emmanuel, Bertrand, Mathieu   +21 more
core   +1 more source

Role of RIPK1/RIPK3/MLKL signalling pathway in sepsis‐associated acute kidney injury

Experimental Physiology, EarlyView.
Abstract Sepsis‐associated acute kidney injury (SA‐AKI) is a common clinical syndrome in critically ill patients, and its high mortality rate is closely related to complex pathological mechanisms. Existing studies have shown that the pathophysiological process of SA‐AKI involves complex multi‐mechanism interactions, including an uncontrolled systemic ...
Huijun Yin, Jingyi Wang, Huirong Han
wiley   +1 more source

Cooperation of TRADD- and RIPK1-dependent cell death pathways in maintaining intestinal homeostasis

Nature Communications
Dysfunctional NF-κB signaling is critically involved in inflammatory bowel disease (IBD). We investigated the mechanism by which RIPK1 and TRADD, two key mediators of NF-κB signaling, in mediating intestinal pathology using TAK1 IEC deficient model.
Ziyu Sun, Jianyu Ye, Weimin Sun, Libo Jiang, Bing Shan, Mengmeng Zhang, Jingyi Xu, Wanjin Li, Jianping Liu, Hongyang Jing, Tian Zhang, Meiling Hou, Cen Xie, Rongling Wu, Heling Pan, Junying Yuan   +15 more
doaj   +1 more source

The mitochondrial‐targeted antioxidant SkQ1 prevents skeletal muscle mitochondrial‐apoptotic but not necroptotic signalling during ovarian cancer

The Journal of Physiology, EarlyView.
Abstract figure legend An evaluation of the degree to which mitochondrial hydrogen peroxide emission (mH2O2)‐mediated apoptotic and necroptotic signalling contributes to skeletal muscle atrophy in an orthotopic epithelial ovarian cancer (EOC) model. To determine whether attenuating mH2O2 could prevent regulated cell death signalling and mitigate muscle
Shahrzad Khajehzadehshoushtar, Luca J. Delfinis, Fasih A. Rahman, Madison C. Garibotti, Shivam Gandhi, Aditya N. Brahmbhatt, Brooke A. Morris, Bianca Garlisi, Sylvia Lauks, Caroline Aitken, Leslie Ogilvie, Zhu‐Xu Zhang, Jeremy A. Simpson, Joe Quadrilatero, Jim Petrik, Christopher G. R. Perry   +15 more
wiley   +1 more source

Shexiang Huayu Xingnao Granule Alleviates Intracerebral Hemorrhage via PI3K/AKT‐Mediated Neuroinflammation Regulation: Integrated Network Pharmacology and Experimental Validation

Brain and Behavior, Volume 16, Issue 11, November 2026.
ABSTRACT Objective Employing network pharmacology prediction combined with experimental validation, this research elucidated the underlying mechanisms of Shexiang Huayu Xingnao granules (SXHY) against intracerebral hemorrhage (ICH). Methods Potential targets and related signaling pathways of SXHY acting on ICH were predicted through network ...
Yuan RuKui, Wang MingLi, Li Chun, Chen MeiJuan, Yuan Yuan   +4 more
wiley   +1 more source

Neointimal Hyperplasia and Restenosis: Epidemiology, Pathophysiology, Animal Models, Clinical Features, Diagnosis, and Management

MedComm, Volume 7, Issue 11, November 2026.
The overall graphical diagram to summarize the pathological characteristics, pathogenesis, clinical manifestation, preclinical animal models, diagnostic methods, and intervention strategies for neointimal hyperplasia. Neointimal hyperplasia results from excessive proliferation and intimal migration of vascular smooth muscle cells (VSMCs) in the ...
Kaixu Wang, Daiyu Zhang, Yu Hu, Yixin Zhao, Xinling Wang, Long Jiang, Meixiu Jiang   +6 more
wiley   +1 more source

Sepsis: Epidemiology, Pathophysiology, and Management

MedComm, Volume 7, Issue 11, November 2026.
Sepsis remains a major global health burden characterized by substantial geographical heterogeneity and a considerable disease burden in China. Its pathophysiology reflects an interconnected network involving excessive inflammation, oxidative stress, immune imbalance and immunoparalysis, mitochondrial damage, endothelial injury, gut dysbiosis ...
Guang‐Tao Pan, Yu Deng, Lin‐Rui Ma, Yu‐Tong Li, Yu Qian, Yi‐Hua Ma, Hai‐Wei Rao, Yi‐Zhun Zhu, Pei‐Yu Yan   +8 more
wiley   +1 more source

Targeting RIPK1 to modulate cell death and tumour microenvironment in cancer therapy

Journal of Enzyme Inhibition and Medicinal Chemistry
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1) is crucial in regulating inflammation, apoptosis, and necroptosis. Accumulating evidence highlights RIPK1 as a promising therapeutic target for various human diseases, including ...
Jing Chen, Shijie Mao, Lingling Huang, Tao Zhu, Yun Bei   +4 more
doaj   +1 more source

Eupatolide, isolated from Liriodendron tulipifera, sensitizes TNF-mediated dual modes of apoptosis and necroptosis by disrupting RIPK1 ubiquitination

Heliyon
Ubiquitination of RIPK1 plays an essential role in the recruitment of the IKK complex, an upstream component of pro-survival NF-κB. It also limits TNF-induced programmed cell death by inhibiting the spatial transition from TNFR1-associated complex-I to ...
Kyeong Ah Park, Chan Seok Jung, Kyung-Cheol Sohn, Eunjin Ju, Sanghee Shin, InWha Park, MinKyun Na, Gang Min Hur   +7 more
doaj   +1 more source