Results 151 to 160 of about 19,353 (245)

Linear ubiquitination in immunity [PDF]

, 2015
Linear ubiquitination is a post-translational protein modification recently discovered to be crucial for innate and adaptive immune signaling. The function of linear ubiquitin chains is regulated at multiple levels: generation, recognition, and removal ...
Aradhya, Belgnaoui, Berger, Bertrand, Bertrand, Bhoj, Bignell, Boisson, Broz, Callahan, Chang, Chen, Chu, Clark, Cullen, Damgaard, Dannappel, De, Dillon, Doffinger, Dondelinger, Dubois, Duong, Dynek, Elgueta, Elliott, Emmerich, Ermolaeva, Fiil, Fiil, Frew, Gay, Gerber, Gerlach, Gijbels, Glickman, Gurung, Haas, Hacker, Hammer, Han, Henson, Heyninck, Hitotsumatsu, Hjerpe, HogenEsch, HogenEsch, HogenEsch, Hospenthal, Hostager, Hubeau, Ikeda, Ikeda, Inn, Iwai, Jiang, Jun, Kaczmarek, Kawai, Kawasaki, Kayagaki, Keusekotten, Kim, Kirisako, Komander, Komander, Komander, Kool, Kulathu, Kulathu, Kumari, Labbe, Lamkanfi, Lamkanfi, Lee, Li, Liang, Lin, Linkermann, Liu, Lo, Lu, Ma, Maelfait, Mann, Martinon, Massoumi, Matmati, Mauro, Mevissen, Michallet, Moulin, Moynagh, Musone, Musone, Nanda, Newton, Ni, Nikolaou, O'Donnell, O'Donnell, O'Neill, Oberst, Opdenbosch, Oshima, Oshiumi, Pannem, Pasparakis, Peltzer, Potter, Py, Rahighi, Reiley, Renninger, Rickard, Ritorto, Rivkin, Rodgers, Sasaki, Sato, Sato, Schaeffer, Schattgen, Schmukle, Schulman, Seymour, Skaug, Stieglitz, Stieglitz, Sun, Sun, Takahashi, Takahashi, Takeuchi, Takiuchi, Tauriello, Tavares, Tokunaga, Tokunaga, Tokunaga, Turer, Vande Walle, Vandenabeele, Varfolomeev, Verhelst, Verhelst, Vince, Vucur, Walczak, Walczak, Wang, Wang, Warner, Wertz, Xu, Yang, Ye, Yoshikawa, Zak, Zhang, Zinngrebe   +160 more
core   +1 more source

Caspase cleavage of RIPK3 after Asp333 is dispensable for mouse embryogenesis

Cell Death and Differentiation
The proteolytic activity of caspase-8 suppresses lethal RIPK1-, RIPK3- and MLKL-dependent necroptosis during mouse embryogenesis. Caspase-8 is reported to cleave RIPK3 in addition to the RIPK3-interacting kinase RIPK1, but whether cleavage of RIPK3 is ...
K. Newton, K. Wickliffe, Allie Maltzman, D. Dugger, Joshua D. Webster, Hongyan Guo, Vishva M. Dixit   +6 more
semanticscholar   +1 more source

RIPK3 and Caspase-8 interpret cytokine signals to regulate ILC3 survival in the gut.

Mucosal Immunology
Group 3 innate lymphoid cells (ILC3s) are abundant in the developing or healthy intestine to critically support tissue homeostasis in response to microbial colonization.
Ann M Joseph, Anees Ahmed, J. Goc, Veronika Horn, Brooke Fiedler, Dario Garone, J. Grigg, Jazib Uddin, Fei Teng, Melanie Fritsch, E. Vivier, Gregory F. Sonnenberg   +11 more
semanticscholar   +1 more source

Ubiquitin-mediated regulation of RIPK1 kinase activity independent of IKK and MK2 [PDF]

, 2018
Tumor necrosis factor (TNF) can drive inflammation, cell survival, and death. While ubiquitylation-, phosphorylation-, and nuclear factor kappa B (NF-kappa B)-dependent checkpoints suppress the cytotoxic potential of TNF, it remains unclear whether ...
Annibaldi, Alessandro, Bertin, John, Bianchi, Katiuscia, Choi, Sze Men, Elliott, Paul R, John, Sidonie Wicky, Komander, David, Liccardi, Gianmaria, Meier, Pascal, Ruan, Jianbin, Silke, John, Swatek, Kirby N, Van Coillie, Samya, Vanden Berghe, Tom, Vandenabeele, Peter, Wu, Hao   +15 more
core   +2 more sources

An inducible RIPK3-driven necroptotic system enhances cancer cell–based immunotherapy and ensures safety

Journal of Clinical Investigation
Recent progress in cancer cell–based therapies has led to effective targeting and robust immune responses against cancer. However, the inherent safety risks of using live cancer cells necessitate the creation of an optimized safety switch without ...
Kok-Siong Chen, Sarah Manoury-Battais, Nobuhiko Kanaya, Ioulia Vogiatzi, P. Borges, Sterre J Kruize, Yi-Ching Chen, Laura Y Lin, Filippo Rossignoli, N. C. Mendonca, Khalid Shah   +10 more
semanticscholar   +1 more source

Caspase-8 functions as a key mediator of inflammation and pro-IL-1β processing via both canonical and non-canonical pathways. [PDF]

, 2015
Caspase-8 is an apical component of cell death pathways. Activated caspase-8 can drive classical caspase-dependent apoptosis and actively inhibits cell death mediated by RIPK3-driven necroptosis.
Bryant, Clare E, Monie, Tom P
core   +2 more sources

Autosis is a Na+,K+-ATPase-regulated form of cell death triggered by autophagy-inducing peptides, starvation, and hypoxia-ischemia. [PDF]

, 2013
A long-standing controversy is whether autophagy is a bona fide cause of mammalian cell death. We used a cell-penetrating autophagy-inducing peptide, Tat-Beclin 1, derived from the autophagy protein Beclin 1, to investigate whether high levels of ...
Clarke, P.G., Ginet, V., Green, D.R., Levine, B., Liu, Y., Posner, B., Puyal, J., Shaw, S.Y., Shoji-Kawata, S., Sumpter, R.M., Tran, K.A., Wei, Y., Xavier, R.J., Zhang, L.   +13 more
core   +1 more source

RIPK3 Mediates Necroptosis during Embryonic Development and Postnatal Inflammation in Fadd-Deficient Mice

Cell Reports, 2017
RIPK3 mediates cell death and regulates inflammatory responses. Although genetic studies have suggested that RIPK3-MLKL-mediated necroptosis leads to embryonic lethality in Fadd or Caspase-8-deficient mice, the exact mechanisms are not fully understood ...
Qun Zhao, XianJun Yu, HaiWei Zhang, YongBo Liu, XiXi Zhang, XiaoXia Wu, Qun Xie, Ming Li, Hao Ying, Haibing Zhang   +9 more
doaj   +1 more source

Prognostic significance and response to immune checkpoint inhibitors of RIPK3, MLKL and necroptosis in non-small cell lung cancer

Scientific Reports
Lung cancer remains the leading cause of cancer death. Treatment with immune checkpoint inhibitor (ICI) alone or combination with chemotherapy served as first-line therapy in non-small cell lung cancer (NSCLC).
Nattaya Duangthim, Thanpisit Lomphithak, R. Saito-Koyama, Y. Miki, C. Inoue, Ikuro Sato, E. Miyauchi, Jiro Abe, Hironobu Sasano, Siriporn Jitkaew   +9 more
semanticscholar   +1 more source

Spatiotemporal control of inflammatory lytic cell death through optogenetic induction of RIPK3 oligomerization.

Journal of Molecular Biology
Necroptosis is a programmed lytic cell death involving active cytokine production and plasma membrane rupture through distinct signaling cascades. However, it remains challenging to delineate this inflammatory cell death pathway at specific signaling ...
Teak-Jung Oh, Vishnu V. Krishnamurthy, Jeong Won Han, Junyao Zhu, Z. Beg, Amna Mehfooz, Bryan Gworek, D. Shapiro, Kai Zhang   +8 more
semanticscholar   +1 more source