Results 171 to 180 of about 19,353 (245)

Intercellular propagation of RIPK1/RIPK3 amyloid fibrils

Proceedings of the National Academy of Sciences
The canonical necrosome formed by receptor-interacting protein kinase 1 (RIPK1) and RIPK3 is a functional amyloid fibril structure critical to intracellularly drive necroptosis. Since necroptosis leads to the release of intracellular content, the fate of RIPK1/RIPK3 fibrils after necroptotic cell death has not been investigated.
Yeyang Ma, Qiuyuan Zhang, Dekang Li, Kun Zhao, Zefei Li, Yuan Liu, Chu Wang, Bo Sun, Dan Li, Junying Yuan, Cong Liu   +10 more
openaire   +1 more source

The neurotoxicant PCB-95 by increasing the neuronal transcriptional repressor REST down-regulates caspase-8 and increases Ripk1, Ripk3 and MLKL expression determining necroptotic neuronal death [PDF]

, 2017
Canzoniero, Lmt, Di Renzo, G, Formisano, L., Guida, N, Laudati, G, Mascolo, L, Molinaro, P, Montuori, P, Serani, A   +8 more
core   +1 more source

Pathway landscape and regulatory networks of epigenetically modified Breast Cancer genes [PDF]

Epigenetic changes are a key regulator of gene expression in different cancer histotypes. After investigating the differentially expressed genes upon treatment with a demethylating agent, e.g.
Capobianco, Enrico, Cinti, Caterina, El Baroudi, Mariama, La Sala, Dario   +3 more
core  

N6-methyladenosine-modified miR-873 promotes receptor-interacting protein kinase 3-mediated necroptosis after intracerebral hemorrhage in mice and HT22 cells. [PDF]

Neuroreport
Wang J, Wang S, Wu X, Lu B, Huang J, Yu D, Zhao S, Chu Z, Yao Y, Xu Y.   +9 more
europepmc   +1 more source

Charged membrane interfaces reshape the nucleation landscape of RIPK3 amyloid variants. [PDF]

Eur Biophys J
Escobedo-González FC, Gelardo A, Titaux-Delgado GA, Mompeán M.   +3 more
europepmc   +1 more source

Targeting MLKL-Driven Necroptosis: A Therapeutic Target in Inflammation and Host Defense. [PDF]

Biomolecules
Saha S, Saso L, Buttari B.
europepmc   +1 more source

Delaying cardiac aging: potential mechanisms centered on PANoptosis and targeted intervention strategies. [PDF]

Front Cardiovasc Med
Shu Y, Li S, Yang S, Zhang S, Li B, Dong L.   +5 more
europepmc   +1 more source

A novel necroptosis pathway: orchestrated by non-canonical STING-ZBP1 signaling. [PDF]

Signal Transduct Target Ther
Zhu X, Liu S, Zhang L.
europepmc   +1 more source

RIPK3 kinase activity determines death pathway [PDF]

Nature Cell Biology, 2014
openaire   +1 more source

The Interaction Between Ferroptosis and Necroptosis in Acute and Chronic Kidney Diseases. [PDF]

J Inflamm Res
Song C, Chen F, Fang Y, Ding X, Han Q, Duan Y, Ren Q, Zhang D, Zhu H.   +8 more
europepmc   +1 more source