Results 81 to 90 of about 19,353 (245)

Neuronal DAMPs exacerbate neurodegeneration via astrocytic RIPK3 signaling

, 2023
AbstractAstrocyte activation is a common feature of neurodegenerative diseases. However, the ways in which dying neurons influence the activity of astrocytes is poorly understood. RIPK3 signaling has recently been described as a key regulator of neuroinflammation, but whether this kinase mediates astrocytic responsiveness to neuronal death has not yet ...
Nydia P. Chang, Evan M. DaPrano, Wesley R. Evans, Marialaina Nissenbaum, Micheal McCourt, Diego Alzate, Marissa Lindman, Tsui-Wen Chou, Colm Atkins, Alexander W. Kusnecov, Rafiq Huda, Brian P. Daniels   +11 more
openaire   +2 more sources

Predominance of Ferroptotic Cell Death Mechanisms in Substantia Nigra Neurodegeneration in Parkinson's Disease

Annals of Neurology, EarlyView.
Objective The extent of neuronal loss in Parkinson's disease (PD) and the pathogenic processes underlying neuronal dysfunction and loss remain poorly understood. Here, we analyzed the expression of key molecules representing different cell death signaling pathways and their association with Lewy pathology, dopaminergic (DA) neuron loss and stage of PD ...
Yue Jing Heng, Anusha Jayaraman, Richard Reynolds, Jia Nee Foo   +3 more
wiley   +1 more source

Investigating the role of receptor interacting protein kinase 3 in venous thrombosis

JVS - Vascular Science, 2022
Objective: Venous thromboembolism is a disease that encompasses both deep vein thrombosis and pulmonary embolism. Recent investigations have shown that receptor interacting protein kinase 3 (RIPK3), a protein known for its role in the programmed form of ...
Elise DeRoo, MD, Mitri Khoury, MD, Ting Zhou, PhD, Huan Yang, PhD, Amelia Stranz, BS, MS, Catherine Luke, LVT, LAT, Peter Henke, MD, Bo Liu, PhD   +7 more
doaj   +1 more source

Encephalitis and poor neuronal death-mediated control of herpes simplex virus in human inherited RIPK3 deficiency

Science immunology, 2023
Inborn errors of TLR3-dependent type I IFN immunity in cortical neurons underlie forebrain herpes simplex virus-1 (HSV-1) encephalitis (HSE) due to uncontrolled viral growth and subsequent cell death.
Zhiyong Liu, Eduardo J. Garcia Reino, O. Harschnitz, Hongyan Guo, Y. Chan, Noopur V Khobrekar, Mary L. Hasek, K. Dobbs, Darawan Rinchai, M. Materna, D. Matuozzo, Danyel Lee, P. Bastard, Jie Chen, Y. Lee, Seong-kon Kim, Shuxiang Zhao, Param Amin, Lazaro Lorenzo, Y. Seeleuthner, Remi Chevalier, Laure Mazzola, Claire Gay, J. Stéphan, Baptiste Milisavljevic, S. Boucherit, F. Rozenberg, R. Pérez de Diego, R. Dix, N. Marr, V. Béziat, A. Cobat, M. Aubart, L. Abel, S. Chabrier, Gregory A. Smith, L. Notarangelo, E. Mocarski, L. Studer, J. Casanova, Shen-Ying Zhang   +40 more
semanticscholar   +1 more source

RIPK1 and RIPK3 - emerging targets in cancer?

Molecular and Cellular Therapies, 2018
RIPK1 and RIPK3 are homologous Ser/Thr kinases, which act in concert within the necrosome complexes to initiate a sub-type of regulated necrosis, termed necroptosis. Necroptosis has gradually emerged as a highly clinically relevant form of necrosis, which can be targeted therapeutically.
Kerem Gurol, Suraj Shah, Alexei Degterev
openaire   +2 more sources

Necroptosis in bacterial infections

Frontiers in Immunology
Necroptosis, a recently discovered form of cell-programmed death that is distinct from apoptosis, has been confirmed to play a significant role in the pathogenesis of bacterial infections in various animal models. Necroptosis is advantageous to the host,
Xing Yu, Jin Yuan, Linxi Shi, Shuying Dai, Lei Yue, Min Yan   +5 more
doaj   +1 more source

Plasma receptor interacting protein kinase-3 levels are associated with acute respiratory distress syndrome in sepsis and trauma: a cohort study

Critical Care, 2019
Background Necroptosis, a form of programmed cell death mediated by receptor interacting serine/threonine-protein kinase-3 (RIPK3), is implicated in murine models of acute respiratory distress syndrome (ARDS).
Michael G. S. Shashaty, John P. Reilly, Hilary E. Faust, Caitlin M. Forker, Caroline A. G. Ittner, Peggy X. Zhang, Meghan J. Hotz, David Fitzgerald, Wei Yang, Brian J. Anderson, Daniel N. Holena, Paul N. Lanken, Jason D. Christie, Nuala J. Meyer, Nilam S. Mangalmurti   +14 more
doaj   +1 more source

Human RIPK3 maintains MLKL in an inactive conformation prior to cell death by necroptosis

Nature Communications, 2021
The pseudokinase MLKL is activated by the upstream kinase RIPK3 in the necroptotic pathway but the structural basis of MLKL activation is not well understood yet.
Yanxiang Meng, Katherine A. Davies, Cheree Fitzgibbon, Samuel N. Young, Sarah E. Garnish, Christopher R. Horne, Cindy Luo, Jean-Marc Garnier, Lung-Yu Liang, Angus D. Cowan, Andre L. Samson, Guillaume Lessene, Jarrod J. Sandow, Peter E. Czabotar, James M. Murphy   +14 more
doaj   +1 more source

RIPK1 is a critical modulator of both tonic and TLR-responsive inflammatory and cell death pathways in human macrophage differentiation [PDF]

, 2018
In this study, we took advantage of human-induced pluripotent stem cells (hiPSC) and CRISPR/Cas9 technology to investigate the potential roles of RIPK1 in regulating hematopoiesis and macrophage differentiation, proinflammatory activation, and cell death
Buchrieser, Julian, Cowley, Sally A., Long, Joshua C. D., Long, Joshua C. D., Moore, Michael D., Oliva Martín, María José, Pérez Simón, José Antonio, Venero Recio, José Luis   +7 more
core   +1 more source

RIPK3–MLKL necroptotic signalling amplifies STING pathway and exacerbates lethal sepsis

Clinical and Translational Medicine, 2023
Backgrounds The stimulator of interferon genes (STING) is an important driver in various inflammatory diseases. Methods and results Here, we have demonstrated that inhibition of RIPK3 and MLKL dampens STING signaling, indicating that necroptosis may be ...
Xufei Zhang, Jie Wu, Qinjie Liu, Xuanheng Li, Yi-yuan Yang, Lei Wu, Xiuwen Wu, Yun Zhao, Jianan Ren   +8 more
semanticscholar   +1 more source