Results 1 to 10 of about 3,542 (132)

Manipulating RKIP reverses the metastatic potential of breast cancer cells [PDF]

Frontiers in Oncology, 2023
Breast cancer is a common tumor type among women, with a high fatality due to metastasis. Metastasis suppressors encode proteins that inhibit the metastatic cascade independent of the primary tumor growth.
Trang Huyen Lai, Mahmoud Ahmed, Jin Seok Hwang, Md Entaz Bahar, Trang Minh Pham, Jinsung Yang, Wanil Kim, Rizi Firman Maulidi, Dong-Kun Lee, Dong-Hee Kim, Hyun Joon Kim, Deok Ryong Kim   +11 more
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Biological and therapeutic implications of RKIP in Gastrointestinal Stromal Tumor (GIST): an integrated transcriptomic and proteomic analysis [PDF]

Cancer Cell International, 2023
Background Gastrointestinal stromal tumors (GIST) represent a significant clinical challenge due to their metastatic potential and limited treatment options.
Nathália Cristina Campanella, Izabela Natalia Faria Gomes, Ana Laura Vieira Alves, Leticia Ferro Leal, Adriane Feijó Evangelista, Marcela Nunes Rosa, Matias Eliseo Melendez, Viviane Aline Oliveira Silva, Richard Lucas Konichi Dias, Lucas Faria Abrahão-Machado, Iara Santana, Olga Martinho, Denise Peixoto Guimarães, Vitor Marcel Faça, Rui Manuel Reis   +14 more
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Cancer resistance via the downregulation of the tumor suppressors RKIP and PTEN expressions: therapeutic implications [PDF]

Exploration of Targeted Anti-tumor Therapy, 2023
The Raf kinase inhibitor protein (RKIP) has been reported to be underexpressed in many cancers and plays a role in the regulation of tumor cells' survival, proliferation, invasion, and metastasis, hence, a tumor suppressor. RKIP also regulates tumor cell
Matthew Moghaddam, Silvia Vivarelli, Luca Falzone, Massimo Libra, Benjamin Bonavida   +4 more
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RKIP inhibition in cervical cancer is associated with higher tumor aggressive behavior and resistance to cisplatin therapy. [PDF]

PLoS ONE, 2013
Cervical cancer is one of the most common cancers in women worldwide, being high-risk group the HPV infected, the leading etiological factor. The raf kinase inhibitory protein (RKIP) has been associated with tumor progression and metastasis in several ...
Olga Martinho, Filipe Pinto, Sara Granja, Vera Miranda-Gonçalves, Marise A R Moreira, Luis F J Ribeiro, Celso di Loreto, Marsha R Rosner, Adhemar Longatto-Filho, Rui Manuel Reis   +9 more
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Diet-induced RKIP downregulation disrupts PC/PE-ER homeostasis to drive MASLD [PDF]

Nature Communications
High-fat diet (HFD) is a risk factor for metabolic dysfunction-associated steatotic liver disease (MASLD), yet the molecular pathways that connect dietary fats to liver dysfunction remain unclear.
Mengjie Li, Qian Ou, Qiang Qin, Jiaxi Chen, Sen Yang, Jie Zhao, Hua Meng, Xu Li, Pinglong Xu, Cunqi Ye, Xiaojian Wang   +10 more
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Unraveling the RKIP–YY1 axis: immune crosstalk in the pathogenesis of metabolic disorders [PDF]

Frontiers in Immunology
Metabolic diseases, including obesity, type 2 diabetes, and cardiovascular disorders, are increasingly recognized as chronic inflammatory conditions driven by dysregulated immune-metabolic interactions.
Fawaz Alzaid, Fawaz Alzaid, Hossein Arefanian, Fatemah Bahman, Shaima Albeloushi, Ghadeer Alhamar, Anwar Mohammad, Amal Hasan, Ashraf Al Madhoun, Rasheed Ahmad, Fahd Al-Mulla   +10 more
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Two Cysteines in Raf Kinase Inhibitor Protein Make Differential Contributions to Structural Dynamics In Vitro [PDF]

Molecules
As a scaffolding protein, Raf kinase binding protein (RKIP) is involved in a variety of cellular pathways, including the Raf–MEK–ERK-cascade. It acts as a negative regulator by binding to its partners, making it an attractive target in the development of
Hyun Sang Cho, Mohammad Faysal Al Mazid, Eun-Young Lee, Md Abu Rayhan, Hyoun Sook Kim, Byung Il Lee, Hye Jin You   +6 more
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RKIP overexpression reduces lung adenocarcinoma aggressiveness and sensitizes cells to EGFR‐targeted therapies [PDF]

Molecular Oncology
Lung adenocarcinoma (LUAD), the most common subtype of non‐small‐cell lung cancer (NSCLC), is often driven by mutations, particularly in epidermal growth factor receptor (EGFR), that guide targeted therapy choices. However, resistance to these treatments
Ana Raquel‐Cunha, Joana Pinheiro, Rui F. Marques, Patrícia Fontão, Diana Cardoso‐Carneiro, Adriana Mendes, Izabela N. F. Gomes, Ana Carolina Laus, Renato J. daSilva‐Oliveira, Rui Manuel Reis, Olga Martinho   +10 more
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RKIP regulates bone marrow macrophage differentiation to mediate osteoclastogenesis and H-type vessel formation [PDF]

Nature Communications
As central cells involved in osteoimmunology, bone niche macrophages possess diverse functions, and their differentiation fate regulates bone homeostasis.
Zeyu Zheng, Siyue Tao, Jiayan Jin, Yansong Li, Liya Dai, Zhaobo Huang, Yihao Zhao, Bao Huang, Saijilafu, Wenlong Lin, Xiaojian Wang, Mengrui Wu, Jian Chen, Fengdong Zhao   +13 more
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The YYR (YY1- RKIP) Regulatory Axis in the pathogenesis of Cancer and Immune Evasion [PDF]

Journal of Experimental & Clinical Cancer Research
Background The transcription factor Yin Yang 1 (YY1) and the Raf kinase inhibitory protein (RKIP) represent two molecular entities with diametrically opposed roles in cancer biology.
William Ung, Benjamin Bonavida
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