Results 11 to 20 of about 3,611 (194)

Regulation of RKIP function by Helicobacter pylori in gastric cancer. [PDF]

PLoS ONE, 2012
Helicobacter pylori (H. pylori) is a gram-negative, spiral-shaped bacterium that infects more than half of the world's population and is a major cause of gastric adenocarcinoma. The mechanisms that link H.
Erika L Moen, Sicheng Wen, Talha Anwar, Sam Cross-Knorr, Kate Brilliant, Faith Birnbaum, Sherida Rahaman, John M Sedivy, Steven F Moss, Devasis Chatterjee   +9 more
doaj   +4 more sources

Bmi-1 promotes the proliferation, migration and invasion, and inhibits cell apoptosis of human retinoblastoma cells via RKIP [PDF]

Scientific Reports
Retinoblastoma is one of the most common ocular malignancies in children. Bmi-1, a member of the Polycomb group family of transcriptional repressors, is expressed in a variety of tumors.
Qian Li, Te Fu, Ning Wei, Qiaoling Wang, Xin Zhang   +4 more
doaj   +2 more sources

Cross-Talks between Raf Kinase Inhibitor Protein and Programmed Cell Death Ligand 1 Expressions in Cancer: Role in Immune Evasion and Therapeutic Implications [PDF]

Cells
Innovations in cancer immunotherapy have resulted in the development of several novel immunotherapeutic strategies that can disrupt immunosuppression. One key advancement lies in immune checkpoint inhibitors (ICIs), which have shown significant clinical ...
Mai Ho, Benjamin Bonavida
doaj   +2 more sources

Prognostic value of RKIP and p-ERK in gastric cancer [PDF]

Journal of Experimental & Clinical Cancer Research, 2012
Background The mitogen-activated protein kinase (MAPK) signaling pathway participates in several steps of tumour development and is considered a prominent therapeutic target for the design of chemotherapeutic agents.
Fujimori Yoshitaka, Inokuchi Mikito, Takagi Yoko, Kato Keiji, Kojima Kazuyuki, Sugihara Kenichi   +5 more
doaj   +3 more sources

Canonical or non-canonical, all aspects of G protein-coupled receptor kinase 2 in heart failure. [PDF]

Acta Physiol (Oxf)
Abstract G protein‐coupled receptor kinase 2 (GRK2) with its multidomain structure performs various crucial cellular functions under both normal and pathological conditions. Overexpression of GRK2 is linked to cardiovascular diseases, and its inhibition or deletion has been shown to be protective.
Kaplan A, El-Samadi L, Zahreddine R, Amin G, Booz GW, Zouein FA.   +5 more
europepmc   +2 more sources

Harnessing RKIP to Combat Heart Disease and Cancer [PDF]

Cancers, 2022
Cancer and heart disease are leading causes of morbidity and mortality worldwide. These diseases have common risk factors, common molecular signaling pathways that are central to their pathogenesis, and even some disease phenotypes that are interdependent.
Kristina Lorenz, Marsha Rich Rosner
openaire   +3 more sources

Raf Kinase Inhibitory Protein protects cells against locostatin-mediated inhibition of migration. [PDF]

PLoS ONE, 2009
Raf Kinase Inhibitory Protein (RKIP, also PEBP1), a member of the Phosphatidylethanolamine Binding Protein family, negatively regulates growth factor signaling by the Raf/MAP kinase pathway.
Anne N Shemon, Eva M Eves, Matthew C Clark, Gary Heil, Alexey Granovsky, Lingchun Zeng, Akira Imamoto, Shohei Koide, Marsha Rich Rosner   +8 more
doaj   +1 more source

RKIP Inhibits Local Breast Cancer Invasion by Antagonizing the Transcriptional Activation of MMP13. [PDF]

PLoS ONE, 2015
Raf Kinase Inhibitory Protein or RKIP was initially identified as a Raf-1 binding protein using the yeast 2-hybrid screen. RKIP inhibits the activation phosphorylation of MEK by Raf-1 by competitively inhibiting the binding of MEK to Raf-1 and thus ...
Ila Datar, Jingwei Feng, Xiaoliang Qiu, John Lewandowski, Miranda Yeung, Gang Ren, Shweta Aras, Fahd Al-Mulla, Hongjuan Cui, Robert Trumbly, Sri Krishna Chaitanya Arudra, Luis E De Las Casas, Ivana de la Serna, Milad S Bitar, Kam C Yeung   +14 more
doaj   +1 more source

Raf kinase inhibitor protein (RKIP) blocks signal transducer and activator of transcription 3 (STAT3) activation in breast and prostate cancer. [PDF]

PLoS ONE, 2014
Raf kinase inhibitor protein (RKIP) is a member of the phosphatidylethanolamine-binding-protein (PEBP) family that modulates the action of many kinases involved in cellular growth, apoptosis, epithelial to mesenchymal transition, motility, invasion and ...
Saad Yousuf, MeiLi Duan, Erika L Moen, Sam Cross-Knorr, Kate Brilliant, Benjamin Bonavida, Theresa LaValle, Kam C Yeung, Fahd Al-Mulla, Eugene Chin, Devasis Chatterjee   +10 more
doaj   +1 more source

Insights of RKIP-Derived Suppression of Prostate Cancer [PDF]

Cancers, 2021
Prostate cancer (PC) is a major cause of cancer death in men. The disease has a great disparity in prognosis. Although low grade PCs with Gleason scores ≤ 6 are indolent, high-risk PCs are likely to relapse and metastasize. The standard of care for metastatic PC (mPC) remains androgen deprivation therapy (ADT). Resistance commonly occurs in the form of
Ying Dong, Xiaozeng Lin, Anil Kapoor, Yan Gu, Hui Xu, Pierre Major, Damu Tang   +6 more
openaire   +2 more sources