Results 21 to 30 of about 3,611 (194)

RKIP Structure Drives Its Function: A Three-State Model for Regulation of RKIP [PDF]

Critical Reviews in Oncogenesis, 2014
Raf kinase inhibitory protein (RKIP) is a highly conserved regulator of many signaling networks whose loss or inactivation can lead to a variety of disease states. The multifaceted roles played by RKIP are enabled by an allosteric structure that is controlled through phosphorylation of RKIP and dynamics in the RKIP pocket loop.
John J, Skinner, Marsha Rich, Rosner
openaire   +2 more sources

Retracted: Dioscorea nipponica Makino Relieves Ovalbumin-Induced Asthma in Mice through Regulating RKIP-Mediated Raf-1/MEK/MAPK/ERK Signaling Pathway. [PDF]

Biomed Res Int
BioMed Research International, Volume 2024, Issue 1, 2024.
International BR.
europepmc   +2 more sources

Characterization of the Raf kinase inhibitory protein (RKIP) binding pocket: NMR-based screening identifies small-molecule ligands. [PDF]

PLoS ONE, 2010
BackgroundRaf kinase inhibitory protein (RKIP), also known as phoshaptidylethanolamine binding protein (PEBP), has been shown to inhibit Raf and thereby negatively regulate growth factor signaling by the Raf/MAP kinase pathway.
Anne N Shemon, Gary L Heil, Alexey E Granovsky, Mathew M Clark, Dan McElheny, Alexander Chimon, Marsha R Rosner, Shohei Koide   +7 more
doaj   +1 more source

Investigation of Marine-Derived Natural Products as Raf Kinase Inhibitory Protein (RKIP)-Binding Ligands

Marine Drugs, 2021
Raf kinase inhibitory protein (RKIP) is an essential regulator of the Ras/Raf-1/MEK/ERK signaling cascade and functions by directly interacting with the Raf-1 kinase.
Shraddha Parate, Vikas Kumar, Jong Chan Hong, Keun Woo Lee   +3 more
doaj   +1 more source

RKIP Regulates Differentiation-Related Features in Melanocytic Cells [PDF]

Cancers, 2020
Raf Kinase Inhibitor Protein (RKIP) has been extensively reported as an inhibitor of key signaling pathways involved in the aggressive tumor phenotype and shows decreased expression in several types of cancers. However, little is known about RKIP in melanoma or regarding its function in normal cells.
Cristina Penas, Aintzane Apraiz, Iraia Muñoa, Yoana Arroyo-Berdugo, Javier Rasero, Pilar A. Ezkurra, Veronica Velasco, Nerea Subiran, Anja K. Bosserhoff, Santos Alonso, Aintzane Asumendi, Maria D. Boyano   +11 more
openaire   +4 more sources

The RAF Kinase Inhibitor Protein (RKIP): Good as Tumour Suppressor, Bad for the Heart

Cells, 2022
The RAF kinase inhibitor protein, RKIP, is a dual inhibitor of the RAF1 kinase and the G protein-coupled receptor kinase 2, GRK2. By inhibition of the RAF1-MAPK (mitogen-activated protein kinase) pathway, RKIP acts as a beneficial tumour suppressor.
Joshua Abd Alla, Ursula Quitterer
doaj   +1 more source

cis-Acting elements and trans-acting factors in the transcriptional regulation of raf kinase inhibitory protein expression. [PDF]

PLoS ONE, 2013
The Raf kinase inhibitory protein (RKIP) is down-regulated in multiple types of human cancers. Decreased RKIP transcription activity may be one of the major mechanisms responsible for the downregulation of RKIP expression in human diseases.
Boyan Zhang, Ou Wang, Jingchao Qin, Shuaishuai Liu, Sheng Sun, Huitu Liu, Jian Kuang, Guohua Jiang, Wei Zhang   +8 more
doaj   +1 more source

Role of pyroptosis in the pathogenesis and treatment of diseases

MedComm, Volume 4, Issue 3, June 2023., 2023
This review summarizes current insights into the complicated relationship between pyroptosis and multiple inflammatory diseases, such as cardiovascular diseases (CVDs), cancer, neurological diseases (NDs), and metabolic diseases (MDs). It also discusses a promising novel strategy and method for treating these inflammatory diseases by targeting ...
Xiangyu Jin, Yinchu Ma, Didi Liu, Yi Huang   +3 more
wiley   +1 more source

Interactions of RKIP with Inflammatory Signaling Pathways [PDF]

Critical Reviews in Oncogenesis, 2014
The inflammatory response plays an important role in host defense and maintenance of homeostasis, while imbalances in these responses can also lead to pathologic disease processes. Emerging data show that RKIP interacts with multiple signaling molecules that may potentiate multiple functions during inflammatory processes.
Jinming, Zhao, Sally, Wenzel
openaire   +2 more sources

GATA6‐AS1 via Sponging miR‐543 to Regulate PTEN/AKT Signaling Axis Suppresses Cell Proliferation and Migration in Gastric Cancer

Mediators of Inflammation, Volume 2023, Issue 1, 2023., 2023
Gastric cancer (GC) is one of the most common and lethal cancers worldwide. In view of the prominent roles of long noncoding RNAs (lncRNAs) in cancers, we investigated the specific role and underlying mechanism of GATA binding protein 6 antisense RNA 1 (GATA6‐AS1) in GC.
Yi Jin, Daqing Jiang, Jinghua Pan
wiley   +1 more source