Epigenetic changes and nuclear factor-\u3baB activation, but not microRNA-224, downregulate Raf-1 kinase inhibitor protein in triple\u2011negative breast cancer SUM 159 cells [PDF]
, 2015 Raf-1 kinase inhibitor protein (RKIP) is a tumor suppressor and metastasis inhibitor, which enhances drug\u2011induced apoptosis of cancer cells. Downregulation of RKIP may be significant in the biology of highly aggressive and drug\u2011resistant tumors,
D'Alessandro, N. +5 more
core +1 more source
A Role for RKIP in Cell Motility [PDF]
Chemistry & Biology, 2005 The target of locostatin, a small-molecule inhibitor of cell movement, has been identified as RKIP, a Raf-1 kinase modulator [1]. In addition to advancing our understanding of cell locomotion, this work represents a major landmark in the development of chemical genetics.
openaire +2 more sources
Stronger computational modelling of signalling pathways using both continuous and discrete-state methods [PDF]
, 2006 Starting from a biochemical signalling pathway model expresses in a process algebra enriched with quantitative information, we automatically derive both continuous-space and discrete-space representations suitable for numerical evaluation.
A. Aziz +19 more
core +5 more sources
TROY interacts with RKIP to promote glioma development [PDF]
Oncogene, 2018 TROY is a component of the Nogo receptor complex and plays the key role in neuronal survival, migration, and differentiation. Here, we show the up-regulation of TROY in human glioma tissues and cells. Inhibition of TROY expression slowed glioma development in vivo and in vitro. Raf kinase inhibitor (RKIP) was found to interact with TROY.
Liu, Xiujie +15 more
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Raf Kinase Inhibitory Protein Down-Expression Exacerbates Hepatic Fibrosis In Vivo and In Vitro
Cellular Physiology and Biochemistry, 2016 Background/Aims: Raf kinase inhibitory protein (RKIP) is closely associated with numerous tumors and participates in their development through regulating the growth, apoptosis, invasion and metastasis of tumor cells.
Quanfang Huang +8 more
doaj +1 more source
An Integrated Qualitative and Quantitative Biochemical Model Learning Framework Using Evolutionary Strategy and Simulated Annealing [PDF]
, 2015 The authors would like to thank the support on this research by the CRISP Project (Combinatorial Responses In Stress Pathways) funded by the BBSRC (BB/F00513X/1) under the Systems Approaches to Biological Research (SABR) Initiative.Peer reviewedPublisher
A Hinton +55 more
core +1 more source
Common reduction of the Raf kinase inhibitory protein in clear cell renal cell carcinoma [PDF]
, 2014 Despite the recent progress in our understanding of clear cell renal cell carcinomas (ccRCCs), the etiology of ccRCC remains unclear. We reported here a prevailing reduction of the raf kinase inhibitory protein (RKIP) in ccRCC. In our examination of more
Bakhtyar, Nazihah +8 more
core +1 more source
Frontiers in Molecular Biosciences, 2021 Protein-protein interactions are indispensable physiological processes regulating several biological functions. Despite the availability of structural information on protein-protein complexes, deciphering their complex topology remains an outstanding ...
Shraddha Parate +4 more
doaj +1 more source
Model reduction and process analysis of biological models [PDF]
, 2015 International audienceUnderstanding the dynamical behavior of biological networks is complicated due to their large number of components and interactions.
Casagranda, Stefano +2 more
core +3 more sources
The biological complexity of RKIP signaling in human cancers [PDF]
Experimental & Molecular Medicine, 2015 The Raf kinase inhibitory protein (RKIP) has been demonstrated to modulate different intracellular signaling pathways in cancers. Studies have shown that RKIP is frequently downregulated in cancers; therefore, attempts have been made to upregulate the expression of RKIP using natural and synthetic agents for the treatment of human malignancies ...
Farooqi, Ammad Ahmad +2 more
openaire +2 more sources