Results 11 to 20 of about 502,163 (208)
Performance comparison of four types of target enrichment baits for exome DNA sequencing
Hereditas, 2021 Background Next-generation sequencing technology is developing rapidly and target capture sequencing has become an important technique. Several different platforms for library preparation and target capture with different bait types respectively are ...
Juan Zhou +5 more
doaj +1 more source
Ultrastructure of influenza virus ribonucleoprotein complexes during viral RNA synthesis
Communications Biology, 2021 Nakano et al. use high-speed AFM and cryo-EM to study influenza virus RNA synthesis in vitro. They observe the synthesis of two types of RNA: folded single stranded RNA associated to an intact viral ribonucleoprotein (vRNP) and looped, double stranded ...
Masahiro Nakano +6 more
doaj +1 more source
Accurate RNA 3D structure prediction using a language model-based deep learning approach [PDF]
Nature Methods 2024, 2022 Accurate prediction of RNA three-dimensional (3D) structure remains an unsolved challenge. Determining RNA 3D structures is crucial for understanding their functions and informing RNA-targeting drug development and synthetic biology design. The structural flexibility of RNA, which leads to scarcity of experimentally determined data, complicates ...
arxiv +1 more source
Contribution of Small RNA Pathway to Interactions of Rice with Pathogens and Insect Pests
Rice, 2021 Small RNAs (sRNAs) are mainly classified into microRNAs (miRNAs) and small interfering RNAs (siRNAs) according to their origin. miRNAs originate from single-stranded RNA precursors, whereas siRNAs originate from double-stranded RNA precursors that are ...
Qin Feng +3 more
doaj +1 more source
UPF1 promotes the formation of R loops to stimulate DNA double-strand break repair
Nature Communications, 2021 R loops are formed when single-stranded RNA anneals to one strand of DNA, forming three-stranded structures containing DNA-RNA hybrids and the displaced non-template single-stranded DNA. Here the authors reveal that the DNA:RNA helicase UPF1 plays a role
Greg H. P. Ngo +2 more
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Human NLRP1 is a sensor for double-stranded RNA
Science, 2020 A dsRNA detector in the immune toolkit Nod-like receptor (NLR) proteins recognize pathogen-associated molecular patterns within cells, which triggers the formation of signaling complexes called inflammasomes.
Stefan Bauernfried +4 more
semanticscholar +1 more source
Биопрепараты: Профилактика, диагностика, лечение, 2023 Scientific relevance. Innate immune activation in the early phases of COVID-19 infection and subsequent interferon induction may help control viral replication and protect cells not yet infected with SARS-CoV-2.
G. M. Ignatyev +5 more
doaj +1 more source
Double Stranded RNA in Human Seminal Plasma
Frontiers in Genetics, 2017 Recently, human semen was shown to contain cell-free nucleic acids, such as DNA, long single stranded RNA, and small RNAs–miRNA and piRNA. The RNAs have been suggested to have potential biological roles as communication molecules between cells and in the
Maxim V. Zagoskin +3 more
doaj +1 more source
Proceedings of the National Academy of Sciences of the United States of America, 1979 The psoralen derivative aminomethyltrioxsalen (AMT, 4'-aminomethyl-4,5',8-trimethylpsoralen) has been employed as a probe for heterogeneous nuclear RNA (hnRNA) double-stranded regions in experiments with living HeLa cells. hnRNA ribonucleoprotein (hnRNP)
J. Calvet, T. Pederson
semanticscholar +1 more source
RNA interference in marine and freshwater sponges [PDF]
, 2011 Background: The marine sponge Tethya wilhelma and the freshwater sponge Ephydatia muelleri are emerging model organisms to study evolution, gene regulation, development, and physiology in non-bilaterian animal systems. Thus far, functional methods (i.e.,
Cieniewicz, Brandon +12 more
core +1 more source