Results 21 to 30 of about 502,163 (208)
Cell Reports, 2014 Double-stranded RNA (dsRNA) can function as genetic information and may have served as genomic material before the existence of DNA-based life. By developing a method to purify dsRNA, we have investigated the diversity of dsRNA in microbial populations ...
Carolyn J. Decker, Roy Parker
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Efficiency of RNA interference is improved by knockdown of dsRNA nucleases in tephritid fruit flies [PDF]
Open Biology, 2019 RNA interference (RNAi) in insects is routinely used to ascertain gene function, but also has potential as a technology to control pest species. For some insects, such as beetles, ingestion of small quantities of double-stranded RNA (dsRNA) is able to ...
Alison Tayler +4 more
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Double-Stranded RNA Technology to Control Insect Pests: Current Status and Challenges
Frontiers in Plant Science, 2020 Exploiting the RNA interference (RNAi) gene mechanism to silence essential genes in pest insects, leading to toxic effects, has surfaced as a promising new control strategy in the past decade.
O. Christiaens +3 more
semanticscholar +1 more source
MicroRNAs: Loquacious Speaks out [PDF]
, 2005 In Drosophila, Dicer-2 requires the double-stranded RNA binding protein R2D2, to mediate the assembly of short interfering RNAs into the RNA-induced silencing complex.
Leuschner, Philipp J.F. +2 more
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TRBP and eIF6 homologue in Marsupenaeus japonicus play crucial roles in antiviral response. [PDF]
PLoS ONE, 2012 Plants and invertebrates can suppress viral infection through RNA silencing, mediated by RNA-induced silencing complex (RISC). Trans-activation response RNA-binding protein (TRBP), consisting of three double-stranded RNA-binding domains, is a component ...
Shuai Wang +4 more
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Insect Science, 2020 RNA interference (RNAi) targeting lethal genes in insects has great potential for sustainable crop protection. Compared with traditional double‐stranded (ds)RNA delivery systems, nanoparticles such as chitosan, liposomes, and cationic dendrimers offer ...
Shuo Yan, Binyuan Ren, Jie Shen
semanticscholar +1 more source
Recognition of two distinct elements in the RNA substrate by the RNA-binding domain of the T. thermophilus DEAD box helicase Hera [PDF]
, 2013 DEAD box helicases catalyze the ATP-dependent destabilization of RNA duplexes. Whereas duplex separation is mediated by the helicase core shared by all members of the family, flanking domains often contribute to binding of the RNA substrate.
Klostermeier, Dagmar +5 more
core +1 more source
Genome Biology, 2023 Existing single-cell RNA sequencing (scRNA-seq) methods rely on reverse transcription (RT) and second-strand synthesis (SSS) to convert single-stranded RNA into double-stranded DNA prior to amplification, with the limited RT/SSS efficiency compromising ...
Jun Lyu, Chongyi Chen
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Targeting mitochondrial metabolites and nucleic acids as an anti-inflammatory strategy
Frontiers in Drug Discovery, 2023 Mitochondrial metabolites and their derivatives have been the focus of recent efforts to develop new anti-inflammatory therapeutics. The widely used therapeutic agents dimethyl fumarate (DMF) and metformin have anti-inflammatory properties and have been ...
Yukun Min, Luke A. J. O’Neill
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Scaling properties of RNA as a randomly branching polymer [PDF]
J. Chem. Phys. 158, 234901 (2023), 2023 Formation of base pairs between the nucleotides of an RNA sequence gives rise to a complex and often highly branched RNA structure. While numerous studies have demonstrated the functional importance of the high degree of RNA branching -- for instance, for its spatial compactness or interaction with other biological macromolecules -- RNA branching ...
arxiv +1 more source