Results 1 to 10 of about 331,513 (191)

Therapeutic potential of small interfering RNAs/micro interfering RNA in hepatocellular carcinoma [PDF]

World Journal of Gastroenterology, 2015
Hepatocellular carcinoma (HCC) is the predominant form of primary liver cancer and represents the third leading cause of cancer-related death worldwide.
DAPAS, BARBARA, FARRA, ROSSELLA, GRASSI, GABRIELE, GRASSI, Mario   +3 more
core   +6 more sources

An endogenous small interfering RNA pathway in Drosophila [PDF]

Nature, 2008
Drosophila endogenous small RNAs are categorized according to their mechanisms of biogenesis and the Argonaute protein to which they bind. MicroRNAs are a class of ubiquitously expressed RNAs of 22 nucleotides in length, which arise from structured ...
A Eulalio, A Stark, AA Aravin, Alexander Stark, AM Denli, Benjamin Czech, C Klattenhoff, Catherine Schlingeheyde, Colin D. Malone, D Galiana-Arnoux, E Allen, E Bernstein, E Yigit, F Jiang, Gregory J. Hannon, J Brennecke, J Jurka, J Pak, J Rehwinkel, James A. Wohlschlegel, JG Ruby, JG Ruby, Julius Brennecke, K Forstemann, K Forstemann, K Okamura, K Saito, K Saito, LS Gunawardane, Manolis Kellis, Monica Dus, N Bushati, Norbert Perrimon, Q Liu, Ravi Sachidanandam, Rui Zhou, T Sijen, VV Vagin, XH Wang, Y Lee, Y Tomari, YS Lee   +41 more
core   +6 more sources

Small Interfering RNA [PDF]

Journal of Investigative Dermatology, 2013
Nambudiri, Vinod E., Widlund, Hans R.
core   +4 more sources

siRNAEfficacyDB: An experimentally supported small interfering RNA efficacy database [PDF]

IET Systems Biology
Small interfering RNA (siRNA) has revolutionised biomedical research and drug development through precise post‐transcriptional gene silencing technology.
Yang Zhang, Ting Yang, Yu Yang, Dongsheng Xu, Yucheng Hu, Shuo Zhang, Nanchao Luo, Lin Ning, Liping Ren   +8 more
doaj   +2 more sources

Potential of siRNA in COVID-19 therapy: Emphasis on in silico design and nanoparticles based delivery

Frontiers in Bioengineering and Biotechnology, 2023
Small interfering RNA (siRNA)-mediated mRNA degradation approach have imparted its eminence against several difficult-to-treat genetic disorders and other allied diseases.
Rushikesh Fopase, Chinmaya Panda, Amarnath P. Rajendran, Hasan Uludag, Hasan Uludag, Hasan Uludag, Lalit M. Pandey   +6 more
doaj   +1 more source

stepRNA: Identification of Dicer cleavage signatures and passenger strand lengths in small RNA sequences

Frontiers in Bioinformatics, 2022
The enzyme Dicer is a component of many small RNA (sRNA) pathways involved in RNA processing for post-transcriptional regulation, anti-viral response and control of transposable elements.
Ben Murcott, Rebecca J. Pawluk, Anna V. Protasio, Ruth Y. Akinmusola, Dominika Lastik, Vicky L. Hunt   +5 more
doaj   +1 more source

Small interfering RNAs in tendon homeostasis

British Medical Bulletin, 2021
Abstract Background Tenogenesis and tendon homeostasis are guided by genes encoding for the structural molecules of tendon fibres. Small interfering RNAs (siRNAs), acting on gene regulation, can therefore participate in the process of tendon healing ...
Nicola Maffulli, Giuseppe Gargano, Giuseppe Gargano, Francesco Oliva, Francesco Oliva, Antonio Oliviero, Antonio Oliviero   +6 more
openaire   +3 more sources

Small interfering RNA inhibition of Andes virus replication. [PDF]

PLoS ONE, 2014
Andes virus (ANDV) is the most common causative agent of hantavirus pulmonary syndrome (HPS) in the Americas, and is the only hantavirus associated with human-to-human transmission. Case fatality rates of ANDV-induced HPS are approximately 40%. There are
Cheng-Feng Chiang, Cesar G Albariňo, Michael K Lo, Christina F Spiropoulou   +3 more
doaj   +1 more source

Potential Application of Small Interfering RNA in Gastro-Intestinal Tumors

Pharmaceuticals, 2022
Despite the progress made in the diagnoses and therapy of gastrointestinal cancers, these diseases are still plagued by a high mortality. Thus, novel therapeutic approaches are urgently required.
Pasquale Losurdo, Nicolò de Manzini, Silvia Palmisano, Mario Grassi, Salvatore Parisi, Flavio Rizzolio, Domenico Tierno, Alice Biasin, Chiara Grassi, Nhung Hai Truong, Gabriele Grassi   +10 more
doaj   +1 more source

Polymers in Small-Interfering RNA Delivery [PDF]

Oligonucleotides, 2011
This review will cover the current strategies that are being adopted to efficiently deliver small interfering RNA using nonviral vectors, including the use of polymers such as polyethylenimine, poly(lactic-co-glycolic acid), polypeptides, chitosan, cyclodextrin, dendrimers, and polymers-containing different nanoparticles.
Singha, K, Namgung, R, Kim, WJ
openaire   +4 more sources