Results 1 to 10 of about 547,696 (232)
Effect of silencing on proliferation and apoptosis of melanoma cells: An in vivo and in vitro study
Tumor Biology, 2017 This study aimed to investigate the effect of SOCS1 silencing on the proliferation and apoptosis of melanoma cells by in vivo and in vitro studies. Immunohistochemical staining was used to detect SOCS1 expression in melanoma tissues and pigmented nevi ...
Sheng-Jia Yu, Zi-Wen Long
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New Insight into Inter-kingdom Communication: Horizontal Transfer of Mobile Small RNAs
Frontiers in Microbiology, 2017 Small RNAs (sRNAs), including small interfering RNAs (siRNAs) and microRNAs (miRNAs), are conventionally regarded as critical molecular regulators of various intracellular processes.
Xi Chen, Geyu Zhou, Yu Zhou
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The optimal concentration of siRNA for gene silencing in primary cultured astrocytes and microglial cells of rats [PDF]
Korean Journal of Anesthesiology, 2010 BackgroundSmall interfering RNAs (siRNAs) have been used to knockdown specific gene expression in various cells. Astrocytes and microglial cells play a key role in fundamental central nervous system functions and in chronic neuroinflammation. The aims of
Kyeong Ho Ki +5 more
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The specifics of small interfering RNA specificity [PDF]
Proceedings of the National Academy of Sciences, 2003 The discovery of transgene silencing in plants and double-stranded RNA (dsRNA) interference in the worm Caenorhabditis elegans has led to the latest revolution in molecular biology, RNA interference (RNAi). Over 10 years ago it was noted that several transgenic plant lines each containing the same ectopic transgene not only failed to be expressed but ...
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Rotavirus gene silencing by small interfering RNAs [PDF]
EMBO reports, 2002 RNA interference is an evolutionarily conserved double‐stranded RNA‐triggered mechanism for suppressing gene expression. Rotaviruses, the leading cause of severe diarrhea in young children, are formed by three concentric layers of protein, from which the spike protein VP4 projects.
Susana López +3 more
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Phenotypic Alteration of BMDM In Vitro Using Small Interfering RNA
Cells, 2022 Autologous macrophage transfer is an emerging platform for cell therapy. It is anticipated that conventional macrophage reprogramming based on ex vivo polarization using cytokines and ligands of TLRs may enhance the therapeutic effect.
Noreen Halimani +11 more
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Delivery of therapeutic small interfering RNA: The current patent-based landscape
Molecular Therapy: Nucleic Acids, 2022 Implementing small interfering RNA (siRNA) is a promising therapy because it silences disease-related genes theoretically. However, the efficient delivery of siRNA is challenging, which limits its therapeutic applications. Various pharmaceutical delivery
Yu Chen +7 more
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Delivering Small Interfering RNA for Novel Therapeutics [PDF]
, 2008 The gene silencing capability of RNA interference (RNAi) is being used to study individual gene's biological function and role in biochemical pathways. However, the efficacy of RNAi depends upon efficient delivery of the intermediates of RNAi, small interfering RNA (siRNA) oligonucleotides.
Patrick Y. Lu, Martin C. Woodle
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Tumor Biology, 2017 Although gene therapy has brought new insights into the treatment of malignant melanoma, targeting delivery of nucleic acid which targets critical oncogene/anti-oncogene in vivo is still a bottleneck in the therapeutic application.
Hao Wang +7 more
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Characterization of the small RNA transcriptome of the diatom, Thalassiosira pseudonana. [PDF]
PLoS ONE, 2011 This study presents the first characterization of endogenous small RNAs in a diatom, Thalassiosira pseudonana. Small RNAs act as transcriptional and translational regulators, controlling specific target genes involved in various cellular functions ...
Trina M Norden-Krichmar +3 more
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