Results 21 to 30 of about 223,182 (263)

Therapeutic potential of small interfering RNAs/micro interfering RNA in hepatocellular carcinoma [PDF]

World Journal of Gastroenterology, 2015
Hepatocellular carcinoma (HCC) is the predominant form of primary liver cancer and represents the third leading cause of cancer-related death worldwide. Current available therapeutic approaches are poorly effective, especially for the advanced forms of the disease.
FARRA, ROSSELLA, GRASSI, Mario, GRASSI, GABRIELE, DAPAS, BARBARA   +3 more
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The optimal concentration of siRNA for gene silencing in primary cultured astrocytes and microglial cells of rats [PDF]

Korean Journal of Anesthesiology, 2010
BackgroundSmall interfering RNAs (siRNAs) have been used to knockdown specific gene expression in various cells. Astrocytes and microglial cells play a key role in fundamental central nervous system functions and in chronic neuroinflammation. The aims of
Kyeong Ho Ki, Do Yang Park, Soo Han Lee, Nam Yun Kim, Byung Moon Choi, Gyu Jeong Noh   +5 more
doaj   +1 more source

An endogenous small interfering RNA pathway in Drosophila [PDF]

Nature, 2008
Drosophila endogenous small RNAs are categorized according to their mechanisms of biogenesis and the Argonaute protein to which they bind. MicroRNAs are a class of ubiquitously expressed RNAs of approximately 22 nucleotides in length, which arise from structured precursors through the action of Drosha-Pasha and Dicer-1-Loquacious complexes.
Czech, Benjamin, Malone, Colin D., Zhou, Rui, Stark, Alexander, Schlingeheyde, Catherine, Dus, Monica, Perrimon, Norbert, Kellis, Manolis, Wohlschlegel, James A., Sachidanandam, Ravi, Hannon, Gregory J., Brennecke, Julius   +11 more
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New Insight into Inter-kingdom Communication: Horizontal Transfer of Mobile Small RNAs

Frontiers in Microbiology, 2017
Small RNAs (sRNAs), including small interfering RNAs (siRNAs) and microRNAs (miRNAs), are conventionally regarded as critical molecular regulators of various intracellular processes.
Xi Chen, Geyu Zhou, Yu Zhou
doaj   +1 more source

Phenotypic Alteration of BMDM In Vitro Using Small Interfering RNA

Cells, 2022
Autologous macrophage transfer is an emerging platform for cell therapy. It is anticipated that conventional macrophage reprogramming based on ex vivo polarization using cytokines and ligands of TLRs may enhance the therapeutic effect.
Noreen Halimani, Mikhail Nesterchuk, Irina N. Andreichenko, Alexandra A. Tsitrina, Andrey Elchaninov, Anastasia Lokhonina, Timur Fatkhudinov, Nataliya O. Dashenkova, Vera Brezgina, Timofei S. Zatsepin, Arsen S. Mikaelyan, Yuri V. Kotelevtsev   +11 more
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Single-chain antibody–delivered Livin siRNA inhibits human malignant melanoma growth in vitro and in vivo

Tumor Biology, 2017
Although gene therapy has brought new insights into the treatment of malignant melanoma, targeting delivery of nucleic acid which targets critical oncogene/anti-oncogene in vivo is still a bottleneck in the therapeutic application.
Hao Wang, Yifei Yang, Wei Wang, Bing Guan, Meng Xun, Hai Zhang, Ziling Wang, Yong Zhao   +7 more
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Delivery of therapeutic small interfering RNA: The current patent-based landscape

Molecular Therapy: Nucleic Acids, 2022
Implementing small interfering RNA (siRNA) is a promising therapy because it silences disease-related genes theoretically. However, the efficient delivery of siRNA is challenging, which limits its therapeutic applications. Various pharmaceutical delivery
Yu Chen, Shi-Hang Xiong, Fei Li, Xiang-Jun Kong, De-Fang Ouyang, Ying Zheng, Hua Yu, Yuan-Jia Hu   +7 more
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Characterization of the small RNA transcriptome of the diatom, Thalassiosira pseudonana. [PDF]

PLoS ONE, 2011
This study presents the first characterization of endogenous small RNAs in a diatom, Thalassiosira pseudonana. Small RNAs act as transcriptional and translational regulators, controlling specific target genes involved in various cellular functions ...
Trina M Norden-Krichmar, Andrew E Allen, Terry Gaasterland, Mark Hildebrand   +3 more
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Small Interfering RNA for Gliomas Treatment: Overcoming Hurdles in Delivery

Frontiers in Cell and Developmental Biology, 2022
Gliomas are central nervous system tumors originating from glial cells, whose incidence and mortality rise in coming years. The current treatment of gliomas is surgery combined with chemotherapy or radiotherapy. However, developing therapeutic resistance
Xin-Qi Teng, Xin-Qi Teng, Xin-Qi Teng, Jian Qu, Guo-Hua Li, Hai-Hui Zhuang, Qiang Qu, Qiang Qu   +7 more
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The specifics of small interfering RNA specificity [PDF]

Proceedings of the National Academy of Sciences, 2003
The discovery of transgene silencing in plants and double-stranded RNA (dsRNA) interference in the worm Caenorhabditis elegans has led to the latest revolution in molecular biology, RNA interference (RNAi). Over 10 years ago it was noted that several transgenic plant lines each containing the same ectopic transgene not only failed to be expressed but ...
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