Potential Application of Small Interfering RNA in Gastro-Intestinal Tumors
Pharmaceuticals, 2022 Despite the progress made in the diagnoses and therapy of gastrointestinal cancers, these diseases are still plagued by a high mortality. Thus, novel therapeutic approaches are urgently required.
Pasquale Losurdo +10 more
doaj +1 more source
A small RNA response at DNA ends in Drosophila [PDF]
, 2012 Small RNAs have been implicated in numerous cellular processes, including effects on chromatin structure and the repression of transposons. We describe the generation of a small RNA response at DNA ends in Drosophila that is analogous to the recently ...
Förstemann, Klaus +2 more
core +1 more source
Recent studies on non-coding small RNAs in plants
浙江大学学报. 农业与生命科学版, 2014 There are many non-coding small RNAs in plants and animals, which regulate gene expression via direct cleavage of target mRNAs or via inhibition of translation at the post-transcriptional level.
Shen Enhui +3 more
doaj +1 more source
Binding of small interfering RNA molecules is crucial for RNA interference suppressor activity of rice hoja blanca virus NS3 in plants [PDF]
, 2009 The NS3 protein of rice hoja blanca tenuivirus represents a viral suppressor of RNAi that sequesters small interfering (si)RNAs in vitro. To determine whether this siRNA binding property is the critical determinant for the suppressor activity of NS3, an ...
Kaaij, L. +5 more
core +1 more source
Diverging affinity of tospovirus RNA silencing suppressor proteins, NSs, for various RNA duplex molecules [PDF]
, 2010 The tospovirus NSs protein was previously shown to suppress the antiviral RNA silencing mechanism in plants. Here the biochemical analysis of NSs proteins from different tospoviruses, using purified NSs or NSs containing cell extracts, is described.
Kormelink, R.J.M. +16 more
core +1 more source
The NS3 protein of rice hoja blanca virus suppresses RNA silencing in mammalian cells [PDF]
, 2008 The NS3 protein of the tenuivirus rice hoja blanca virus (RHBV) has previously been shown to represent the viral RNA interference (RNAi) suppressor and is active in both plant and insect cells by binding short interfering RNAs (siRNAs) in vitro.
Hemmes, J.C. +3 more
core +1 more source
Computational discovery of animal small RNA genes and targets [PDF]
, 2007 Though recently discovered, small RNAs appear to play a wealth of regulatory roles, being involved in degradation of target mRNAs, translation silencing of target genes, chromatin remodeling and transposon silencing.
Gaidatzis, Dimosthenis
core +1 more source
Role of RNA Interference (RNAi) in the Moss Physcomitrella patens [PDF]
, 2013 RNA interference (RNAi) is a mechanism that regulates genes by either transcriptional (TGS) or posttranscriptional gene silencing (PTGS), required for genome maintenance and proper development of an organism.
Arif, M. +8 more
core +2 more sources
RNA interference is responsible for reduction of transgene expression after Sleeping Beauty transposase mediated somatic integration. [PDF]
, 2012 Integrating non-viral vectors based on transposable elements are widely used for genetically engineering mammalian cells in functional genomics and therapeutic gene transfer.
Anja Ehrhardt +7 more
core +2 more sources
RNA Interference by Single- and Double-stranded siRNA With a DNA Extension Containing a 3′ Nuclease-resistant Mini-hairpin Structure [PDF]
, 2013 Selective gene silencing by RNA interference (RNAi) involves double-stranded small interfering RNA (ds siRNA) composed of single-stranded (ss) guide and passenger RNAs.
Jo Milner +4 more
core +1 more source