Results 21 to 30 of about 222,382 (219)
Medicinal Chemistry of Oligonucleotide Drugs - Milestones of the Past and Visions for the Future
CHIMIA, 2022 The oligonucleotide therapeutics field has blossomed in recent years, with thirteen approved drugs today and the promise of accelerated growth in coming years.
Jonathan Hall +7 more
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Small interfering RNA against BCR-ABL transcripts sensitize mutated T315I cells to nilotinib
Haematologica, 2010 Background Selective inhibition of the BCR-ABL tyrosine kinase by RNA interference has been demonstrated in leukemic cells. We, therefore, evaluated specific BCR-ABL small interfering RNA silencing in BCR-ABL-positive cell lines, including those ...
Michael Koldehoff +3 more
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Short Hairpin RNAs for Strand-Specific Small Interfering RNA Production
Frontiers in Bioengineering and Biotechnology, 2020 RNA interference (RNAi) is an effective mechanism for inhibiting gene expression at the post-transcriptional level. Expression of a messenger RNA (mRNA) can be inhibited by a ∼22-nucleotide (nt) small interfering (si)RNA with the corresponding reverse ...
Peike Sheng +6 more
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Effect of silencing on proliferation and apoptosis of melanoma cells: An in vivo and in vitro study
Tumor Biology, 2017 This study aimed to investigate the effect of SOCS1 silencing on the proliferation and apoptosis of melanoma cells by in vivo and in vitro studies. Immunohistochemical staining was used to detect SOCS1 expression in melanoma tissues and pigmented nevi ...
Sheng-Jia Yu, Zi-Wen Long
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The optimal concentration of siRNA for gene silencing in primary cultured astrocytes and microglial cells of rats [PDF]
Korean Journal of Anesthesiology, 2010 BackgroundSmall interfering RNAs (siRNAs) have been used to knockdown specific gene expression in various cells. Astrocytes and microglial cells play a key role in fundamental central nervous system functions and in chronic neuroinflammation. The aims of
Kyeong Ho Ki +5 more
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New Insight into Inter-kingdom Communication: Horizontal Transfer of Mobile Small RNAs
Frontiers in Microbiology, 2017 Small RNAs (sRNAs), including small interfering RNAs (siRNAs) and microRNAs (miRNAs), are conventionally regarded as critical molecular regulators of various intracellular processes.
Xi Chen, Geyu Zhou, Yu Zhou
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Journal of Biomedical Science, 2023 RNA has emerged as a revolutionary and important tool in the battle against emerging infectious diseases, with roles extending beyond its applications in vaccines, in which it is used in the response to the COVID-19 pandemic.
Hara Kang +6 more
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Delivery of therapeutic small interfering RNA: The current patent-based landscape
Molecular Therapy: Nucleic Acids, 2022 Implementing small interfering RNA (siRNA) is a promising therapy because it silences disease-related genes theoretically. However, the efficient delivery of siRNA is challenging, which limits its therapeutic applications. Various pharmaceutical delivery
Yu Chen +7 more
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Tumor Biology, 2017 Although gene therapy has brought new insights into the treatment of malignant melanoma, targeting delivery of nucleic acid which targets critical oncogene/anti-oncogene in vivo is still a bottleneck in the therapeutic application.
Hao Wang +7 more
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Small Interfering RNA for Gliomas Treatment: Overcoming Hurdles in Delivery
Frontiers in Cell and Developmental Biology, 2022 Gliomas are central nervous system tumors originating from glial cells, whose incidence and mortality rise in coming years. The current treatment of gliomas is surgery combined with chemotherapy or radiotherapy. However, developing therapeutic resistance
Xin-Qi Teng +7 more
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