Results 11 to 20 of about 348,149 (303)

Endogenous small interfering RNAs in animals [PDF]

Nature Reviews Molecular Cell Biology, 2008
Until recently, only nematodes among animals had a well-defined endogenous small interfering RNA (endo-siRNA) pathway. This has changed dramatically with the recent discovery of diverse intramolecular and intermolecular substrates that generate endo-siRNAs in Drosophila melanogaster and mice.
Katsutomo, Okamura, Eric C, Lai
openaire   +4 more sources

Therapeutic potential of small interfering RNAs/micro interfering RNA in hepatocellular carcinoma [PDF]

World Journal of Gastroenterology, 2015
Hepatocellular carcinoma (HCC) is the predominant form of primary liver cancer and represents the third leading cause of cancer-related death worldwide.
DAPAS, BARBARA, FARRA, ROSSELLA, GRASSI, GABRIELE, GRASSI, Mario   +3 more
core   +5 more sources

Small interfering RNAs in tendon homeostasis

British Medical Bulletin, 2021
Abstract Background Tenogenesis and tendon homeostasis are guided by genes encoding for the structural molecules of tendon fibres. Small interfering RNAs (siRNAs), acting on gene regulation, can therefore participate in the process of tendon healing ...
Gargano, Giuseppe, Oliviero, Antonio, Oliva, Francesco, Maffulli, Nicola   +3 more
openaire   +4 more sources

An endogenous small interfering RNA pathway in Drosophila [PDF]

Nature, 2008
Drosophila endogenous small RNAs are categorized according to their mechanisms of biogenesis and the Argonaute protein to which they bind. MicroRNAs are a class of ubiquitously expressed RNAs of 22 nucleotides in length, which arise from structured ...
A Eulalio, A Stark, AA Aravin, Alexander Stark, AM Denli, Benjamin Czech, C Klattenhoff, Catherine Schlingeheyde, Colin D. Malone, D Galiana-Arnoux, E Allen, E Bernstein, E Yigit, F Jiang, Gregory J. Hannon, J Brennecke, J Jurka, J Pak, J Rehwinkel, James A. Wohlschlegel, JG Ruby, JG Ruby, Julius Brennecke, K Forstemann, K Forstemann, K Okamura, K Saito, K Saito, LS Gunawardane, Manolis Kellis, Monica Dus, N Bushati, Norbert Perrimon, Q Liu, Ravi Sachidanandam, Rui Zhou, T Sijen, VV Vagin, XH Wang, Y Lee, Y Tomari, YS Lee   +41 more
core   +3 more sources

Medicinal Chemistry of Oligonucleotide Drugs - Milestones of the Past and Visions for the Future

CHIMIA, 2022
The oligonucleotide therapeutics field has blossomed in recent years, with thirteen approved drugs today and the promise of accelerated growth in coming years.
Jonathan Hall, Anastasia Ashkinadze, Jan Philipp Becker, Artur Laski, Eva-Maria Manz, Štefan Moravčík, Sebastian Sjöström, Mathilde Vincent   +7 more
doaj   +1 more source

The antiviral RNAi response in vector and non-vector cells against orthobunya viruses [PDF]

, 2017
Background: Vector arthropods control arbovirus replication and spread through antiviral innate immune responses including RNA interference (RNAi) pathways. Arbovirus infections have been shown to induce the exogenous small interfering RNA (siRNA) and
Bausch, DG, Blomström, AL, Dietrich, I, Elliott, RM, Kohl, A, McFarlane, M, Schnettler, E, Shi, X, Skelton, JK, Watson, M   +9 more
core   +5 more sources

Small interfering RNA against BCR-ABL transcripts sensitize mutated T315I cells to nilotinib

Haematologica, 2010
Background Selective inhibition of the BCR-ABL tyrosine kinase by RNA interference has been demonstrated in leukemic cells. We, therefore, evaluated specific BCR-ABL small interfering RNA silencing in BCR-ABL-positive cell lines, including those ...
Michael Koldehoff, Lambros Kordelas, Dietrich W. Beelen, Ahmet H. Elmaagacli   +3 more
doaj   +1 more source

Transfer RNA-derived small RNAs in the cancer transcriptome [PDF]

, 2016
The cellular lifetime includes stages such as differentiation, proliferation, division, senescence and apoptosis.These stages are driven by a strictly ordered process of transcription dynamics.
A Dueck, A Sobala, AE Hall, AM Burroughs, C Cole, C Fricke, D Green, D Haussecker, D Kim, Darrell Green, DM Thompson, DP Bartel, DR Rhodes, FE Nicolas, GL Hager, H Fu, H Goodarzi, I Salaverria, JM Perkel, M Ghildiyal, M Talpaz, MS Pagter de, NC Schopman, O Rechavi, P Adjibade, P Ivanov, P Kumar, P Kumar, Q Wang, R Levitz, RL Maute, S Yamasaki, SC Stearns, T Uchiumi, Tamas Dalmay, U Harms, William D. Fraser, YS Lee, Z Li   +38 more
core   +1 more source

Polymers in Small-Interfering RNA Delivery [PDF]

Oligonucleotides, 2011
This review will cover the current strategies that are being adopted to efficiently deliver small interfering RNA using nonviral vectors, including the use of polymers such as polyethylenimine, poly(lactic- co -glycolic acid), polypeptides, chitosan, cyclodextrin, dendrimers, and polymers ...
Singha, K, Namgung, R, Kim, WJ
openaire   +3 more sources

An influenza virus-inspired polymer system for the timed release of siRNA [PDF]

, 2013
Small interfering RNA silences specific genes by interfering with mRNA translation, and acts to modulate or inhibit specific biological pathways; a therapy that holds great promise in the cure of many diseases. However, the naked small interfering RNA is
A Fire, A Turchinovich, AD Judge, AJ Convertine, B Ozpolat, BM Rosen, C Pichon, C Pichon, C Plank, D Smith, DL McKenzie, DV Schaffer, DW Pack, EM Saurer, F Yamauchi, I Le Blanc, I Prasadam, J Soutschek, K Miyata, KA Whitehead, KF Ren, L Dieguez, M Kurisawa, ME Davis, NP Truong, NP Truong, P Midoux, RG Handwerger, RKM Leung, S Dincer, S Mehrotra, S Wu, SB Zhang, T Lammers, TS Zimmermann, V Percec, YW Cho, ZF Duan   +37 more
core   +2 more sources