Results 11 to 20 of about 547,696 (232)

Therapeutic potential of small interfering RNAs/micro interfering RNA in hepatocellular carcinoma [PDF]

World Journal of Gastroenterology, 2015
Hepatocellular carcinoma (HCC) is the predominant form of primary liver cancer and represents the third leading cause of cancer-related death worldwide. Current available therapeutic approaches are poorly effective, especially for the advanced forms of the disease.
FARRA, ROSSELLA, GRASSI, Mario, GRASSI, GABRIELE, DAPAS, BARBARA   +3 more
core   +8 more sources

An endogenous small interfering RNA pathway in Drosophila [PDF]

Nature, 2008
Drosophila endogenous small RNAs are categorized according to their mechanisms of biogenesis and the Argonaute protein to which they bind. MicroRNAs are a class of ubiquitously expressed RNAs of approximately 22 nucleotides in length, which arise from structured precursors through the action of Drosha-Pasha and Dicer-1-Loquacious complexes.
Manolis Kellis, Benjamin Czech, Norbert Perrimon, Alexander Stark, Alexander Stark, Julius Brennecke, Ravi Sachidanandam, Monica Dus, Catherine Schlingeheyde, James A. Wohlschlegel, Gregory J. Hannon, Colin D. Malone, Rui Zhou   +12 more
core   +8 more sources

Small interfering RNA (siRNA)-based therapeutic applications against viruses: principles, potential, and challenges

Journal of Biomedical Science, 2023
RNA has emerged as a revolutionary and important tool in the battle against emerging infectious diseases, with roles extending beyond its applications in vaccines, in which it is used in the response to the COVID-19 pandemic.
Hara Kang, Yun Ji Ga, Soo Hyun Kim, Young Hoon Cho, Jung Won Kim, Chaeyeon Kim, Jung-Yong Yeh   +6 more
doaj   +2 more sources

Polymers in Small-Interfering RNA Delivery [PDF]

Oligonucleotides, 2011
This review will cover the current strategies that are being adopted to efficiently deliver small interfering RNA using nonviral vectors, including the use of polymers such as polyethylenimine, poly(lactic-co-glycolic acid), polypeptides, chitosan, cyclodextrin, dendrimers, and polymers-containing different nanoparticles.
Singha, K, Namgung, R, Kim, WJ
openaire   +5 more sources

Unzipping and binding of small interfering RNA with single walled carbon nanotube: A platform for small interfering RNA delivery [PDF]

The Journal of Chemical Physics, 2012
In an effort to design efficient platform for siRNA delivery, we combine all atom classical and quantum simulations to study the binding of small interfering RNA (siRNA) by pristine single wall carbon nanotube (SWCNT). Our results show that siRNA strongly binds to SWCNT surface via unzipping its base-pairs and the propensity of unzipping increases with
Santosh, Mogurampelly, Panigrahi, Swati, Bhattacharyya, Dhananjay, Sood, AK, Maiti, Prabal K   +4 more
openaire   +6 more sources

Small Interfering RNAs Targeting VP4, VP3, 2B, or 3A Coding Regions of Enterovirus A71 Inhibit Viral Replication In Vitro [PDF]

Biomedicines
Background: Enterovirus A71 (EV-A71) is considered as the primary causative agent of hand, foot, and mouth disease (HFMD) in young children, leading to severe neurological complications and contributing to substantial mortalities in recent HFMD outbreaks
Yun Ji Ga, Yun Young Go, Jung-Yong Yeh
doaj   +2 more sources

Nanoparticle-based delivery of small interfering RNA: challenges for cancer therapy

International Journal of Nanomedicine, 2012
Evelina Miele,1,* Gian Paolo Spinelli,2,* Ermanno Miele,3 Enzo Di Fabrizio,3,6 Elisabetta Ferretti,4 Silverio Tomao,2 Alberto Gulino,1,5 1Department of Molecular Medicine, 2Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University ...
Miele E, Spinelli GP, Miele E, Di Fabrizio E, Ferretti E, Tomao S, Gulino A   +6 more
doaj   +2 more sources

Effects of LINC00261 targeting miR-148a/WNT10b axis on the proliferation and apoptosis of colorectal cancer cells

Heliyon, 2023
Objective: Colorectal cancer remains a significant challenge with high mortality rates. The aim of this study was to investigate the effect of targeting the microRNA-148a/WNT10b axis with the long non-coding RNA LINC00261 on the proliferation and ...
Juanli Xi, Lei Shi, DingJie Zhou, Dedong Cao, Bo Peng   +4 more
doaj   +1 more source

Certain Adenylated Non-Coding RNAs, Including 5′ Leader Sequences of Primary MicroRNA Transcripts, Accumulate in Mouse Cells following Depletion of the RNA Helicase MTR4 [PDF]

, 2014
RNA surveillance plays an important role in posttranscriptional regulation. Seminal work in this field has largely focused on yeast as a model system, whereas exploration of RNA surveillance in mammals is only recently begun.
Anderson, James T., Dorweiler, Jane E., Munroe, Stephen, Ni, Ting, Zhu, Jun   +4 more
core   +19 more sources

Small Interfering RNA to Reduce Lipoprotein(a) in Cardiovascular Disease.

New England Journal of Medicine, 2022
BACKGROUND Lipoprotein(a) is a presumed risk factor for atherosclerotic cardiovascular disease. Olpasiran is a small interfering RNA that reduces lipoprotein(a) synthesis in the liver. METHODS We conducted a randomized, double-blind, placebo-controlled,
M. O’Donoghue, R. Rosenson, B. Gencer, J. A. López, N. Lepor, S. Baum, Elmer Stout, D. Gaudet, B. Knusel, J. Kuder, Xinhui Ran, S. Murphy, Hong Wang, You Wu, H. Kassahun, M. Sabatine   +15 more
semanticscholar   +1 more source