Results 21 to 30 of about 547,696 (232)

Potential of siRNA in COVID-19 therapy: Emphasis on in silico design and nanoparticles based delivery

Frontiers in Bioengineering and Biotechnology, 2023
Small interfering RNA (siRNA)-mediated mRNA degradation approach have imparted its eminence against several difficult-to-treat genetic disorders and other allied diseases.
Rushikesh Fopase, Chinmaya Panda, Amarnath P. Rajendran, Hasan Uludag, Hasan Uludag, Hasan Uludag, Lalit M. Pandey   +6 more
doaj   +1 more source

Small interfering RNAs in tendon homeostasis

British Medical Bulletin, 2021
Abstract Background Tenogenesis and tendon homeostasis are guided by genes encoding for the structural molecules of tendon fibres. Small interfering RNAs (siRNAs), acting on gene regulation, can therefore participate in the process of tendon healing ...
Nicola Maffulli, Giuseppe Gargano, Giuseppe Gargano, Francesco Oliva, Francesco Oliva, Antonio Oliviero, Antonio Oliviero   +6 more
openaire   +3 more sources

Small interfering RNA: Discovery, pharmacology and clinical development—An introductory review

British Journal of Pharmacology, 2022
Post‐transcriptional gene silencing targets and degrades mRNA transcripts, silencing the expression of specific genes. RNA interference technology, using synthetic structurally well‐defined short double‐stranded RNA (small interfering RNA [siRNA]), has ...
P. Ranasinghe, M. Addison, J. Dear, David J. Webb   +3 more
semanticscholar   +1 more source

Antisense Oligonucleotides and Small Interfering RNA for the Treatment of Dyslipidemias

Journal of Clinical Medicine, 2022
The burden of atherosclerotic disease worldwide necessitates implementing the treatment of its risk factors. Among them, hypercholesterolemia has a central role.
C. Gareri, A. Polimeni, Salvatore Giordano, Laura Tammè, A. Curcio, C. Indolfi   +5 more
semanticscholar   +1 more source

stepRNA: Identification of Dicer cleavage signatures and passenger strand lengths in small RNA sequences

Frontiers in Bioinformatics, 2022
The enzyme Dicer is a component of many small RNA (sRNA) pathways involved in RNA processing for post-transcriptional regulation, anti-viral response and control of transposable elements.
Ben Murcott, Rebecca J. Pawluk, Anna V. Protasio, Ruth Y. Akinmusola, Dominika Lastik, Vicky L. Hunt   +5 more
doaj   +1 more source

Amelioration of post-traumatic osteoarthritis via nanoparticle depots delivering small interfering RNA to damaged cartilage

Nature Biomedical Engineering, 2021
The progression of osteoarthritis is associated with inflammation triggered by the enzymatic degradation of extracellular matrix in injured cartilage. Here we show that a locally injected depot of nanoparticles functionalized with an antibody targeting ...
Sean K. Bedingfield, J. Colazo, Fang Yu, Danielle D. Liu, Meredith A. Jackson, L. Himmel, Hongsik Cho, L. Crofford, K. Hasty, C. Duvall   +9 more
semanticscholar   +1 more source

A small interfering RNA (siRNA) database for SARS-CoV-2

Scientific Reports, 2021
Coronavirus disease 2019 (COVID-19) rapidly transformed into a global pandemic, for which a demand for developing antivirals capable of targeting the SARS-CoV-2 RNA genome and blocking the activity of its genes has emerged.
Inácio Gomes Medeiros, André Salim Khayat, Beatriz Stransky, Sidney Santos, Paulo Assumpção, Jorge Estefano Santana de Souza   +5 more
doaj   +1 more source

Potential Application of Small Interfering RNA in Gastro-Intestinal Tumors

Pharmaceuticals, 2022
Despite the progress made in the diagnoses and therapy of gastrointestinal cancers, these diseases are still plagued by a high mortality. Thus, novel therapeutic approaches are urgently required.
Pasquale Losurdo, Nicolò de Manzini, Silvia Palmisano, Mario Grassi, Salvatore Parisi, Flavio Rizzolio, Domenico Tierno, Alice Biasin, Chiara Grassi, Nhung Hai Truong, Gabriele Grassi   +10 more
doaj   +1 more source

Small interfering RNA inhibition of Andes virus replication. [PDF]

PLoS ONE, 2014
Andes virus (ANDV) is the most common causative agent of hantavirus pulmonary syndrome (HPS) in the Americas, and is the only hantavirus associated with human-to-human transmission. Case fatality rates of ANDV-induced HPS are approximately 40%. There are
Cheng-Feng Chiang, Cesar G Albariňo, Michael K Lo, Christina F Spiropoulou   +3 more
doaj   +1 more source

Small RNA modifications: regulatory molecules and potential applications

Journal of Hematology & Oncology, 2023
Small RNAs (also referred to as small noncoding RNAs, sncRNA) are defined as polymeric ribonucleic acid molecules that are less than 200 nucleotides in length and serve a variety of essential functions within cells.
Qunli Xiong, Yaguang Zhang
semanticscholar   +1 more source