A small RNA response at DNA ends in Drosophila [PDF]
, 2012 Small RNAs have been implicated in numerous cellular processes, including effects on chromatin structure and the repression of transposons. We describe the generation of a small RNA response at DNA ends in Drosophila that is analogous to the recently ...
Böttcher, Romy +2 more
core +1 more source
Heliyon, 2023 Objective: Colorectal cancer remains a significant challenge with high mortality rates. The aim of this study was to investigate the effect of targeting the microRNA-148a/WNT10b axis with the long non-coding RNA LINC00261 on the proliferation and ...
Juanli Xi +4 more
doaj
Short Hairpin RNAs for Strand-Specific Small Interfering RNA Production
Frontiers in Bioengineering and Biotechnology, 2020 RNA interference (RNAi) is an effective mechanism for inhibiting gene expression at the post-transcriptional level. Expression of a messenger RNA (mRNA) can be inhibited by a ∼22-nucleotide (nt) small interfering (si)RNA with the corresponding reverse ...
Peike Sheng +6 more
doaj +1 more source
The optimal concentration of siRNA for gene silencing in primary cultured astrocytes and microglial cells of rats [PDF]
Korean Journal of Anesthesiology, 2010 BackgroundSmall interfering RNAs (siRNAs) have been used to knockdown specific gene expression in various cells. Astrocytes and microglial cells play a key role in fundamental central nervous system functions and in chronic neuroinflammation. The aims of
Kyeong Ho Ki +5 more
doaj +1 more source
Journal of Biomedical Science, 2023 RNA has emerged as a revolutionary and important tool in the battle against emerging infectious diseases, with roles extending beyond its applications in vaccines, in which it is used in the response to the COVID-19 pandemic.
Hara Kang +6 more
doaj +1 more source
Global analyses of endonucleolytic cleavage in mammals reveal expanded repertoires of cleavage-inducing small RNAs and their targets. [PDF]
, 2016 In mammals, small RNAs are important players in post-transcriptional gene regulation. While their roles in mRNA destabilization and translational repression are well appreciated, their involvement in endonucleolytic cleavage of target RNAs is poorly ...
Bahn, Jae Hoon +7 more
core +2 more sources
Certain Adenylated Non-Coding RNAs, Including 5′ Leader Sequences of Primary MicroRNA Transcripts, Accumulate in Mouse Cells following Depletion of the RNA Helicase MTR4 [PDF]
, 2014 RNA surveillance plays an important role in posttranscriptional regulation. Seminal work in this field has largely focused on yeast as a model system, whereas exploration of RNA surveillance in mammals is only recently begun.
Anderson, James T. +4 more
core +10 more sources
Effect of silencing on proliferation and apoptosis of melanoma cells: An in vivo and in vitro study
Tumor Biology, 2017 This study aimed to investigate the effect of SOCS1 silencing on the proliferation and apoptosis of melanoma cells by in vivo and in vitro studies. Immunohistochemical staining was used to detect SOCS1 expression in melanoma tissues and pigmented nevi ...
Sheng-Jia Yu, Zi-Wen Long
doaj +1 more source
New Insight into Inter-kingdom Communication: Horizontal Transfer of Mobile Small RNAs
Frontiers in Microbiology, 2017 Small RNAs (sRNAs), including small interfering RNAs (siRNAs) and microRNAs (miRNAs), are conventionally regarded as critical molecular regulators of various intracellular processes.
Xi Chen, Geyu Zhou, Yu Zhou
doaj +1 more source
Small Interfering RNA for Gliomas Treatment: Overcoming Hurdles in Delivery
Frontiers in Cell and Developmental Biology, 2022 Gliomas are central nervous system tumors originating from glial cells, whose incidence and mortality rise in coming years. The current treatment of gliomas is surgery combined with chemotherapy or radiotherapy. However, developing therapeutic resistance
Xin-Qi Teng +7 more
doaj +1 more source