Results 21 to 30 of about 414,473 (272)
Heliyon, 2023 Objective: Colorectal cancer remains a significant challenge with high mortality rates. The aim of this study was to investigate the effect of targeting the microRNA-148a/WNT10b axis with the long non-coding RNA LINC00261 on the proliferation and ...
Juanli Xi +4 more
doaj
Short Hairpin RNAs for Strand-Specific Small Interfering RNA Production
Frontiers in Bioengineering and Biotechnology, 2020 RNA interference (RNAi) is an effective mechanism for inhibiting gene expression at the post-transcriptional level. Expression of a messenger RNA (mRNA) can be inhibited by a ∼22-nucleotide (nt) small interfering (si)RNA with the corresponding reverse ...
Peike Sheng +6 more
doaj +1 more source
Journal of Biomedical Science, 2023 RNA has emerged as a revolutionary and important tool in the battle against emerging infectious diseases, with roles extending beyond its applications in vaccines, in which it is used in the response to the COVID-19 pandemic.
Hara Kang +6 more
doaj +1 more source
Small Interfering RNA for Gliomas Treatment: Overcoming Hurdles in Delivery
Frontiers in Cell and Developmental Biology, 2022 Gliomas are central nervous system tumors originating from glial cells, whose incidence and mortality rise in coming years. The current treatment of gliomas is surgery combined with chemotherapy or radiotherapy. However, developing therapeutic resistance
Xin-Qi Teng +7 more
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MicroRNAs -- targeting and target prediction [PDF]
N Biotechnol. 2010 Jul 31;27(3):243-9, 2015 MicroRNAs (miRNAs) are a class of small noncoding RNAs that can regulate many genes by base pairing to sites in mRNAs. The functionality of miRNAs overlaps that of short interfering RNAs (siRNAs), and many features of miRNA targeting have been revealed experimentally by studying miRNA-mimicking siRNAs.
arxiv +1 more source
Effect of silencing on proliferation and apoptosis of melanoma cells: An in vivo and in vitro study
Tumor Biology, 2017 This study aimed to investigate the effect of SOCS1 silencing on the proliferation and apoptosis of melanoma cells by in vivo and in vitro studies. Immunohistochemical staining was used to detect SOCS1 expression in melanoma tissues and pigmented nevi ...
Sheng-Jia Yu, Zi-Wen Long
doaj +1 more source
New Insight into Inter-kingdom Communication: Horizontal Transfer of Mobile Small RNAs
Frontiers in Microbiology, 2017 Small RNAs (sRNAs), including small interfering RNAs (siRNAs) and microRNAs (miRNAs), are conventionally regarded as critical molecular regulators of various intracellular processes.
Xi Chen, Geyu Zhou, Yu Zhou
doaj +1 more source
Characterization of the small RNA transcriptome of the diatom, Thalassiosira pseudonana. [PDF]
PLoS ONE, 2011 This study presents the first characterization of endogenous small RNAs in a diatom, Thalassiosira pseudonana. Small RNAs act as transcriptional and translational regulators, controlling specific target genes involved in various cellular functions ...
Trina M Norden-Krichmar +3 more
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Vascular endothelial‐cadherin as a marker of endothelial injury in preclinical Alzheimer disease
Annals of Clinical and Translational Neurology, Volume 9, Issue 12, Page 1926-1940, December 2022., 2022 Abstract Objective Endothelial dysfunction is an early and prevalent pathology in Alzheimer disease (AD). We here investigate the value of vascular endothelial‐cadherin (VEC) as a cerebrospinal fluid (CSF) marker of endothelial injury in preclinical AD.
Rawan Tarawneh +5 more
wiley +1 more source
Phenotypic Alteration of BMDM In Vitro Using Small Interfering RNA
Cells, 2022 Autologous macrophage transfer is an emerging platform for cell therapy. It is anticipated that conventional macrophage reprogramming based on ex vivo polarization using cytokines and ligands of TLRs may enhance the therapeutic effect.
Noreen Halimani +11 more
doaj +1 more source