Results 41 to 50 of about 547,696 (232)

Small interfering RNA against BCR-ABL transcripts sensitize mutated T315I cells to nilotinib

Haematologica, 2010
Background Selective inhibition of the BCR-ABL tyrosine kinase by RNA interference has been demonstrated in leukemic cells. We, therefore, evaluated specific BCR-ABL small interfering RNA silencing in BCR-ABL-positive cell lines, including those ...
Michael Koldehoff, Lambros Kordelas, Dietrich W. Beelen, Ahmet H. Elmaagacli   +3 more
doaj   +1 more source

An influenza virus-inspired polymer system for the timed release of siRNA [PDF]

, 2013
Small interfering RNA silences specific genes by interfering with mRNA translation, and acts to modulate or inhibit specific biological pathways; a therapy that holds great promise in the cure of many diseases. However, the naked small interfering RNA is
A Fire, A Turchinovich, AD Judge, AJ Convertine, B Ozpolat, BM Rosen, C Pichon, C Pichon, C Plank, D Smith, DL McKenzie, DV Schaffer, DW Pack, EM Saurer, F Yamauchi, I Le Blanc, I Prasadam, J Soutschek, K Miyata, KA Whitehead, KF Ren, L Dieguez, M Kurisawa, ME Davis, NP Truong, NP Truong, P Midoux, RG Handwerger, RKM Leung, S Dincer, S Mehrotra, S Wu, SB Zhang, T Lammers, TS Zimmermann, V Percec, YW Cho, ZF Duan   +37 more
core   +2 more sources

Short Hairpin RNAs for Strand-Specific Small Interfering RNA Production

Frontiers in Bioengineering and Biotechnology, 2020
RNA interference (RNAi) is an effective mechanism for inhibiting gene expression at the post-transcriptional level. Expression of a messenger RNA (mRNA) can be inhibited by a ∼22-nucleotide (nt) small interfering (si)RNA with the corresponding reverse ...
Peike Sheng, Peike Sheng, Krystal A. Flood, Krystal A. Flood, Mingyi Xie, Mingyi Xie, Mingyi Xie   +6 more
doaj   +1 more source

Transfer RNA-derived small RNAs in the cancer transcriptome [PDF]

, 2016
The cellular lifetime includes stages such as differentiation, proliferation, division, senescence and apoptosis.These stages are driven by a strictly ordered process of transcription dynamics.
A Dueck, A Sobala, AE Hall, AM Burroughs, C Cole, C Fricke, D Green, D Haussecker, D Kim, Darrell Green, DM Thompson, DP Bartel, DR Rhodes, FE Nicolas, GL Hager, H Fu, H Goodarzi, I Salaverria, JM Perkel, M Ghildiyal, M Talpaz, MS Pagter de, NC Schopman, O Rechavi, P Adjibade, P Ivanov, P Kumar, P Kumar, Q Wang, R Levitz, RL Maute, S Yamasaki, SC Stearns, T Uchiumi, Tamas Dalmay, U Harms, William D. Fraser, YS Lee, Z Li   +38 more
core   +1 more source

RNA Interference by Production of Short Hairpin dsRNA in ES Cells, Their Differentiated Derivatives, and in Somatic Cell Lines [PDF]

, 2003
dsRNA of several hundred nucleotides in length is effective at interfering with gene expression in mouse oocytes, pre-implantation embryos, and embryonic stem (ES) cells but is not as efficient in differentiated cell lines.
Glover, D. M., Grabarek, J. B., Plusa, B., Wianny, F., Zernicka-Goetz, M.   +4 more
core   +1 more source

Super-resolution Imaging of Proton Sponge-Triggered Rupture of Endosomes and Cytosolic Release of Small Interfering RNA.

ACS Nano, 2019
The intracellular delivery of nucleic acids and proteins remains a key challenge in the development of biological therapeutics. In gene therapy, the inefficient delivery of small interfering RNA (siRNA) to the cytosol by lipoplexes or polyplexes is often
Marcin Wojnilowicz, A. Glab, A. Bertucci, F. Caruso, F. Cavalieri   +4 more
semanticscholar   +1 more source

RNA Interference by Single- and Double-stranded siRNA With a DNA Extension Containing a 3′ Nuclease-resistant Mini-hairpin Structure [PDF]

, 2013
Selective gene silencing by RNA interference (RNAi) involves double-stranded small interfering RNA (ds siRNA) composed of single-stranded (ss) guide and passenger RNAs.
Ahmed, Allison, Beckerman, Bunz, Burnett, Carthew, Castanotto, Chen, Chendrimada, Dunn, Ford, Ford, Haigis, Haringsma, Hirao, Jiang, Jiang, Jiang, Jollès, Khan, Kim, Knight, Liu, Liu, Lynch, Parker, Peritz, Rao, Rivas, Réfrégiers, Shah, Siomi, Song, Vickers, Wang, Wang, Wang, Ye, Yoshizawa   +38 more
core   +6 more sources

Binding of small interfering RNA molecules is crucial for RNA interference suppressor activity of rice hoja blanca virus NS3 in plants [PDF]

, 2009
The NS3 protein of rice hoja blanca tenuivirus represents a viral suppressor of RNAi that sequesters small interfering (si)RNAs in vitro. To determine whether this siRNA binding property is the critical determinant for the suppressor activity of NS3, an ...
Goldbach, R.W., Hemmes, J.C., Kaaij, L., Lohuis, H., Prins, M.W., Schnettler, E.   +5 more
core   +2 more sources

Strong and Sustained Antihypertensive Effect of Small Interfering RNA Targeting Liver Angiotensinogen

HYPERTENSION, 2019
Small interfering RNAs (siRNAs) targeting hepatic angiotensinogen (Agt) may provide long-lasting antihypertensive effects, but the optimal approach remains unclear.
Estrellita Uijl, K. M. Colafella, K. M. Colafella, Yuan Sun, Liwei Ren, R. Veghel, I. Garrelds, R. Vries, M. Poglitsch, Ivan Zlatev, Jae B. Kim, E. Hoorn, Donald J. Foster, A. Danser   +13 more
semanticscholar   +1 more source

Global analyses of endonucleolytic cleavage in mammals reveal expanded repertoires of cleavage-inducing small RNAs and their targets. [PDF]

, 2016
In mammals, small RNAs are important players in post-transcriptional gene regulation. While their roles in mRNA destabilization and translational repression are well appreciated, their involvement in endonucleolytic cleavage of target RNAs is poorly ...
Bahn, Jae Hoon, Cass, Ashley A, Greer, Christopher, Hsiao, Yun-Hua Esther, Kim, Yong, Lee, Jae-Hyung, Lin, Xianzhi, Xiao, Xinshu   +7 more
core   +2 more sources