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Precursors of U4 small nuclear RNA. [PDF]
The Journal of cell biology, 1984 The processing and ribonucleoprotein assembly of U4 small nuclear RNA has been investigated in HeLa cells. After a 45-min pulse label with [3H]uridine, a set of apparently cytoplasmic RNAs was observed migrating just behind the gel electrophoretic position of mature U4 RNA.
S J, Madore +3 more
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New small nuclear RNA gene-like transcriptional units as sources of regulatory transcripts. [PDF]
PLoS Genetics, 2007 By means of a computer search for upstream promoter elements (distal sequence element and proximal sequence element) typical of small nuclear RNA genes, we have identified in the human genome a number of previously unrecognized, putative transcription ...
Aldo Pagano +5 more
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Spliceosomal snRNA Epitranscriptomics
Frontiers in Genetics, 2021 Small nuclear RNAs (snRNAs) are critical components of the spliceosome that catalyze the splicing of pre-mRNA. snRNAs are each complexed with many proteins to form RNA-protein complexes, termed as small nuclear ribonucleoproteins (snRNPs), in the cell ...
Pedro Morais, Hironori Adachi, Yi-Tao Yu
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Frontiers in Microbiology, 2022 Fomitopsis is a worldwide brown-rot fungal genus of Polyporales, which grows on different gymnosperm and angiosperm trees and has important ecological functions and economic values.
Shun Liu +5 more
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Ancient Origin of the U2 Small Nuclear RNA Gene-Targeting Non-LTR Retrotransposons Utopia. [PDF]
PLoS ONE, 2015 Most non-long terminal repeat (non-LTR) retrotransposons encoding a restriction-like endonuclease show target-specific integration into repetitive sequences such as ribosomal RNA genes and microsatellites.
Kenji K Kojima, Jerzy Jurka
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Mutually Exclusive CBC-Containing Complexes Contribute to RNA Fate
Cell Reports, 2017 The nuclear cap-binding complex (CBC) stimulates processing reactions of capped RNAs, including their splicing, 3′-end formation, degradation, and transport.
Simone Giacometti +12 more
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Nuclear Retention Elements of U3 Small Nucleolar RNA [PDF]
Molecular and Cellular Biology, 1999 The processing and methylation of precursor rRNA is mediated by the box C/D small nucleolar RNAs (snoRNAs). These snoRNAs differ from most cellular RNAs in that they are not exported to the cytoplasm. Instead, these RNAs are actively retained in the nucleus where they assemble with proteins into mature small nucleolar ribonucleoprotein particles and ...
W, Speckmann +3 more
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Transcriptional regulation of human small nuclear RNA genes [PDF]
Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 2008 The products of human snRNA genes have been frequently described as performing housekeeping functions and their synthesis refractory to regulation. However, recent studies have emphasized that snRNA and other related non-coding RNA molecules control multiple facets of the central dogma, and their regulated expression is critical to cellular homeostasis
Gauri W, Jawdekar, R William, Henry
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FEBS Letters, EarlyView.Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi +5 more
wiley +1 more source
Sphingomyelin regulates the transcriptional machinery in nuclear lipid microdomains
Communications BiologyNuclear lipid microdomains rich in sphingomyelin and cholesterol content regulate double-stranded exonuclease-resistant RNA. The study aimed to elucidate the importance of nuclear lipid microdomains in safeguarding nuclear RNA from digestion and to ...
Carmela Conte +17 more
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