Results 41 to 50 of about 498,663 (149)

Miniature Inverted-Repeat Transposable Elements: Small DNA Transposons That Have Contributed to Plant MICRORNA Gene Evolution

Plants, 2023
Angiosperms form the largest phylum within the Plantae kingdom and show remarkable genetic variation due to the considerable difference in the nuclear genome size of each species.
Joseph L. Pegler, Jackson M. J. Oultram, Christopher W. G. Mann, Bernard J. Carroll, Christopher P. L. Grof, Andrew L. Eamens   +5 more
doaj   +1 more source

Decoding m6Am by simultaneous transcription-start mapping and methylation quantification

eLife
N 6,2’-O-dimethyladenosine (m6Am) is a modified nucleotide located at the first transcribed position in mRNA and snRNA that is essential for diverse physiological processes. m6Am mapping methods assume each gene uses a single start nucleotide.
Jianheng Fox Liu, Ben R Hawley, Luke S Nicholson, Samie R Jaffrey   +3 more
doaj   +1 more source

Data on the stability of Prx1-associated snRNAs and mRNAs

Data in Brief, 2019
This data set is related to the research article entitled “Peroxiredoxin 1 post-transcriptionally regulates snoRNA expression” (Kim et al., 2019). It demonstrates that peroxiredoxin 1 (Prx1) increases the stability of Prx1-associated small nuclear RNAs ...
Eun-Kyung Kim, Sung-Min Ahn, Ho Hee Jang
doaj  

RNA-Based Liquid Biopsy in Head and Neck Cancer

Cells, 2023
Head and neck cancer (HNC) is a prevalent and diverse group of malignancies with substantial morbidity and mortality rates. Early detection and monitoring of HNC are crucial for improving patient outcomes.
Jacek Kabzinski, Aleksandra Kucharska-Lusina, Ireneusz Majsterek   +2 more
doaj   +1 more source

Transcriptional regulation of human small nuclear RNA genes [PDF]

Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 2008
The products of human snRNA genes have been frequently described as performing housekeeping functions and their synthesis refractory to regulation. However, recent studies have emphasized that snRNA and other related non-coding RNA molecules control multiple facets of the central dogma, and their regulated expression is critical to cellular homeostasis
R. William Henry, Gauri W. Jawdekar
openaire   +3 more sources

An engineered U7 small nuclear RNA scaffold greatly increases ADAR-mediated programmable RNA base editing

Nature Communications
Custom RNA base editing exploiting the human Adenosine Deaminase Acting on RNA (ADAR) enzyme may enable therapeutic gene editing without DNA damage or use of foreign proteins.
Susan M. Byrne, Stephen M. Burleigh, Robert Fragoza, Yue Jiang, Yiannis Savva, Ricky Pabon, Evan Kania, Joseph Rainaldi, Andrew Portell, Prashant Mali, Adrian W. Briggs   +10 more
doaj   +1 more source

Transcription: Surprising Role for an Elusive Small Nuclear RNA [PDF]

Current Biology, 2002
Since 7SK was discovered as an abundant small nuclear RNA in the mid-70s, its role has remained tantalizingly unsolved. Two recent studies have shown that 7SK acts as a negative regulator of the RNA polymerase II elongation factor P-TEFb, and that this activity is influenced by stress response pathways.
openaire   +2 more sources

Loss of function mutations in GEMIN5 cause a neurodevelopmental disorder

Nature Communications, 2021
GEMIN5, an RNA-binding protein, is required for formation of small nuclear ribonucleoproteins. Here, the authors identify loss of function mutations in GEMIN5 that are associated with a human neurodevelopmental disorder.
Sukhleen Kour, Deepa S. Rajan, Tyler R. Fortuna, Eric N. Anderson, Caroline Ward, Youngha Lee, Sangmoon Lee, Yong Beom Shin, Jong-Hee Chae, Murim Choi, Karine Siquier, Vincent Cantagrel, Jeanne Amiel, Elliot S. Stolerman, Sarah S. Barnett, Margot A. Cousin, Diana Castro, Kimberly McDonald, Brian Kirmse, Andrea H. Nemeth, Dhivyaa Rajasundaram, A. Micheil Innes, Danielle Lynch, Patrick Frosk, Abigail Collins, Melissa Gibbons, Michele Yang, Isabelle Desguerre, Nathalie Boddaert, Cyril Gitiaux, Siri Lynne Rydning, Kaja K. Selmer, Roser Urreizti, Alberto Garcia-Oguiza, Andrés Nascimento Osorio, Edgard Verdura, Aurora Pujol, Hannah R. McCurry, John E. Landers, Sameer Agnihotri, E. Corina Andriescu, Shade B. Moody, Chanika Phornphutkul, Maria J. Guillen Sacoto, Amber Begtrup, Henry Houlden, Janbernd Kirschner, David Schorling, Sabine Rudnik-Schöneborn, Tim M. Strom, Steffen Leiz, Kali Juliette, Randal Richardson, Ying Yang, Yuehua Zhang, Minghui Wang, Jia Wang, Xiaodong Wang, Konrad Platzer, Sandra Donkervoort, Carsten G. Bönnemann, Matias Wagner, Mahmoud Y. Issa, Hasnaa M. Elbendary, Valentina Stanley, Reza Maroofian, Joseph G. Gleeson, Maha S. Zaki, Jan Senderek, Udai Bhan Pandey   +69 more
doaj   +1 more source

Nucleotide sequence of Dictyostelium small nuclear RNA Dd8 not homologous to any other sequenced small nuclear RNA.

Journal of Biological Chemistry, 1983
The cellular slime mold Dictyostelium discoideum, a lower eukaryote, was shown to contain several species of small nuclear RNA (Takeishi, K., and Kaneda, S. (1981) J. Biochem. (Tokyo) 90, 299-308; Wise, J. A., and Weiner, A. M. (1981) J. Biol. Chem. 256, 956-963).
Osamu Gotoh, Keiichi Takeishi, Takeshi Seno, S Kaneda   +3 more
openaire   +3 more sources

Importin/exportin-mediated nucleocytoplasmic shuttling of cucumber mosaic virus 2b protein is required for 2b's efficient suppression of RNA silencing.

PLoS Pathogens, 2022
The 2b protein (2b) of cucumber mosaic virus (CMV), an RNA-silencing suppressor (RSS), is a major pathogenicity determinant of CMV. 2b is localized in the nucleus and cytoplasm, and its nuclear import is determined by two nuclear localization signals ...
Hangil Kim, Hanako Shimura, Kae Sueda, Chikara Masuta   +3 more
doaj   +1 more source