Results 51 to 60 of about 5,120 (129)

Fusion protein condensate formation via coiled‐coil domains

Protein Science, Volume 35, Issue 7, July 2026.
Abstract While recent research shows that biomolecular condensates play important roles in normal cellular processes and diseases, the driving forces in condensate formation are not well understood, especially regarding the role of structured self‐associative protein domains.
Om Prakash Narayan, Lu Liu, Kyle Scheller, Carter Humphrey, Jiawei Dong, Juan Guan   +5 more
wiley   +1 more source

Trk Inhibition Reduces Tumorsphere Formation and Changes Expression of Stemness Markers in SK-ES-1 Ewing Sarcoma Cells

Revista Brasileira de Cancerologia
Introduction: Ewing sarcoma (ES) is a highly aggressive type of childhood cancer characterized by a chromosomal translocation resulting in fusions between the gene encoding EWS RNA Binding Protein 1 (EWSR1) and one gene of the ETS family, most ...
Rafael Pereira dos Santos, Bruna Almeida dos Santos, Lauro Gregianin, André Tessainer Brunetto, Algemir Lunardi Brunetto, Rafael Roesler, Caroline Brunetto de Farias   +6 more
doaj   +1 more source

Multiaxial Biophysical Control of Oncogenic Phase Separation by Indoleamines: A Proof‐of‐Concept Synthesis of Landscape‐Level Regulation

Journal of Pineal Research, Volume 78, Issue 4, July 2026.
ABSTRACT Oncogenic condensates act as biophysical sanctuaries that stabilize malignant survival programs. However, a universal regulator capable of orchestrating the integrated biophysical axes governing cellular phase behavior has remained elusive.
Doris Loh, Luiz Gustavo de Almeida Chuffa, Fábio Rodrigues Ferreira Seiva, Russel J. Reiter   +3 more
wiley   +1 more source

Full‐Length Next‐Generation Sequencing of 11 HLA Loci of More Than 1000 Individuals From Clinical Cohorts in East and West Africa

HLA, Volume 108, Issue 1, July 2026.
ABSTRACT HLA loci have been implicated in several diseases, including HIV‐1, from different world populations. It is necessary to characterise HLA allele variation at the population level prior to investigating associations linked to human diseases. In global databases, limited high‐resolution HLA allele types generated by next‐generation sequencing ...
Yvonne V. Rosario, Aviva Geretz, Lakshmi Rani Iyer, Philip K. Ehrenberg, Alýa Tyson, Hannah Kibuuka, Fred Wabwire‐Mangen, Lucas Maganga, Abdulwasiu Tiamiyu, Jonah Maswai, Josphat Kosgei, Frederick Sawe, Gary R. Matyas, Merlin L. Robb, Julie A. Ake, Rasmi Thomas   +15 more
wiley   +1 more source

Cellular Dynamics of Transgenic Porcine Endothelial Cells to Inflammatory Stimuli in Xenotransplantation Settings

Xenotransplantation, Volume 33, Issue 4, July/August 2026.
ABSTRACT Inflammatory responses have been shown to contribute significantly to the rejection of grafts in both allo‐ and xenotransplantation. In particular, they play a pivotal role in promoting endothelial activation, complement deposition, and thrombosis, thereby compromising the graft function.
Mitra Gultom, Nina Thomi, Kassandra Teixeira‐Riberio, Jane Shaw, Alain Despont, Nikolai Klymiuk, Elisabeth Kemter, Eckhard Wolf, Robert Rieben   +8 more
wiley   +1 more source

METTL3-mediated SNHG1 m6A modification promotes proliferation and migration through transcriptional regulation of WDR74 in osteosarcoma

Frontiers in Oncology
IntroductionAs the most prevalent internal RNA modification in eukaryotic transcripts, N6-methyladenosine (m6A) which is catalyzed by methyltransferase-like 3 (METTL3), is widely involved in cancerous diseases.
Guanzhen Qiu, Yuxin Bao, Yuanzhuang Zhang, Yeqiu Xu, Tianhua Qiao, Chenghao Li, Hanjie Zhai, Zhenjun Chen, Fu Ren, Yong Wang   +9 more
doaj   +1 more source

Classic Ewing Sarcoma of the Ankle With Ewing Sarcoma RNA-Binding Protein 1-Friend Leukemia Integration 1 (EWSR1/FLI1) Fusion: A Case Report and Review of Diagnostic Considerations

Cureus
Ewing sarcoma (ES) is a malignant small round blue cell tumor most frequently arising in the long bones of adolescents and young adults, characterized by a translocation involving the Ewing sarcoma RNA-binding protein 1 (EWSR1) gene, most commonly the EWSR1/friend leukemia integration 1 (FLI1) fusion.
Nikolaus, Yanina, Urbelz, Gabriel
openaire   +2 more sources

Predicting cervical cancer DNA methylation from genetic data using multivariate CMMP

Canadian Journal of Statistics, Volume 54, Issue 2, June 2026.
Abstract Epigenetic modifications link the environment to gene expression and play a crucial role in tumour development. DNA methylation, in particular, is gaining attention in cancer research, including cervical cancer, the focus of this study.
Hang Zhang, Steven Chen, Raymond Balise, Jiming Jiang, Nagi Ayad, J. Sunil Rao   +5 more
wiley   +1 more source

Hepatocellular Carcinoma LINC01116 Outcompetes T Cells for Linoleic Acid and Accelerates Tumor Progression

Advanced Science
Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer with a highly immunosuppressive tumor microenvironment and a typical pattern of disturbances in hepatic lipid metabolism.
Kun Ma, Junhui Chu, Yufeng Liu, Linmao Sun, Shuo Zhou, Xianying Li, Changyong Ji, Ning Zhang, Xinyu Guo, Shuhang Liang, Tianming Cui, Qingsong Hu, Jiabei Wang, Yao Liu, Lianxin Liu   +14 more
doaj   +1 more source

Progress in Natural Products Target Discovery Technology

MedComm, Volume 7, Issue 6, June 2026.
Here, we provide a comprehensive overview of current technologies and recent advancements in therapeutic target discovery for natural products. By systematically synthesizing the principles, methodologies, and practical applications of existing experimental and computational strategies, this work provides a more actionable reference framework for ...
Qiyuan Pan, Xiao Yuan, Jinmei Jin, Xin Luan, Cheng Luo, Hongzhuan Chen, Weidong Zhang, Hao Zhang   +7 more
wiley   +1 more source