Results 61 to 70 of about 5,120 (129)
MedComm – Oncology, Volume 5, Issue 2, June 2026.CHD4 plays an essential role as an epigenetic regulator in the pathogenesis of multiple myeloma. The chromatin remodeling protein initially resolves G‐quadruplex (G4) secondary structures within the c‐Myc promoter region, thereby enhancing chromatin accessibility and promoting transcriptional activation.
Pinggang Ding +10 more
wiley +1 more source
Redox BiologyColorectal cancer (CRC), propelled by extreme molecular heterogeneity and intractable drug resistance, is rapidly becoming a global health challenge.
Ling Zhu +6 more
doaj +1 more source
IMMUNOSARC II Master Trial: Phase II Study of Sunitinib and Nivolumab in Clear Cell Sarcoma Cohort
Cancer CommunicationsBackground: Clear cell sarcoma (CCS) is an ultrarare sarcoma driven by a specific chromosomal translocation, most commonly the EWS RNA binding protein 1–activating transcription factor 1 fusion (EWSR1::ATF1), for which chemotherapy shows limited activity,
Javier Martin-Broto +27 more
doaj +1 more source
iMetaHomoharringtonine (HHT) is widely used in combination regimens for acute myeloid leukemia (AML), yet its direct cellular targets remain undefined, limiting precision application. Here, we identified EWS RNA‐binding protein 1 (EWSR1) as the primary target
Ting‐Ting Liu +17 more
doaj +1 more source
Characterization of PHRF1, a novel SR-like CTD-associated protein
, 2012 Systemic lupus erythematosus, SLE, is an autoimmune inflammatory disease characterized by antinuclear autoantibodies, interferon activation and tissue destruction. The susceptibility of SLE disease has shown to be linked with genetic variations. Recently,
박지혜
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MicroRNA regulation by the DNA and RNA binding proteins EWS and FUS
, 2012 As proteínas EWS (Ewing sarcoma breakpoint region 1), FUS [Fused in sarcoma ou TLS (Translocated in liposarcoma)] e TAF15 (TATA box binding protein-associated factor) fazem parte da família de proteínas denominada FET (FUS, EWS e TAF15). A região amino-terminal destas proteínas é composta por um domínio de activação transcricional enquanto a região C ...
openaire +1 more source
BCOR-2::MAML1 és AHR::BCOR génfúziók onkogén tulajdonságainak in silico vizsgálata szarkómákban
A BCOR (BCL-6 korepresszor) gén az X-kromoszóma rövid karján (Xp11.4) helyezkedik el, és fokozza a BCL-6 által közvetített transzkripciós repressziót.
Fábián, Luca
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