Results 41 to 50 of about 5,120 (129)

Therapeutic targeting of circ‐CUX1/EWSR1/MAZ axis inhibits glycolysis and neuroblastoma progression

EMBO Molecular Medicine, 2019
Aerobic glycolysis is a hallmark of metabolic reprogramming in tumor progression. However, the mechanisms regulating glycolytic gene expression remain elusive in neuroblastoma (NB), the most common extracranial malignancy in childhood.
Huanhuan Li, Feng Yang, Anpei Hu, Xiaojing Wang, Erhu Fang, Yajun Chen, Dan Li, Huajie Song, Jianqun Wang, Yanhua Guo, Yang Liu, Hongjun Li, Kai Huang, Liduan Zheng, Qiangsong Tong   +14 more
doaj   +1 more source

Transcriptome Analysis of Long Non-coding RNAs and Genes Encoding Paraspeckle Proteins During Human Ovarian Follicle Development

Frontiers in Cell and Developmental Biology, 2018
Emerging evidence indicated that many long non-coding (lnc)RNAs function in multiple biological processes and dysregulation of their expression can cause diseases.
Emil H. Ernst, Julie Nielsen, Malene B. Ipsen, Palle Villesen, Palle Villesen, Karin Lykke-Hartmann, Karin Lykke-Hartmann, Karin Lykke-Hartmann   +7 more
doaj   +1 more source

KMT5C‐Mediated H4K20me3 Recruits EWSR1 to Propel Clear Cell Renal Cell Carcinoma Progression via Regulating ACADM Transcription and m6A Modification

Med Research, EarlyView.
A schematic diagram illustrating the KMT5C‐H4K20me3‐EWSR1‐ACADM signaling axis and its role in ccRCC progression. Key Outcomes: KMT5C/H4K20me3 are upregulated in ccRCC and predict poor prognosis. EWSR1 is a novel noncanonical H4K20me3 reader in ccRCC. KMT5C/EWSR1 co‐repress ACADM via transcription and m6A modification. A‐196 + sunitinib synergistically
Chengjian Ji, Da Zhong, Tian Rao, Xiaojun Li, Weiyu Kong, Xi Zhang, Xiyi Wei, Bing Yao, Xinqiang Li, Ninghong Song, Chao Qin   +10 more
wiley   +1 more source

Cabeza, aDrosophilagene encoding a novel RNA binding protein, shares homology with EWS and TLS, two genes involved in human sarcoma formation

Nucleic Acids Research, 1995
We have previously described a partial Drosophila cDNA, clone P19, which bears homology to members of the RNA recognition motif (RRM) family of proteins [Haynes et al. (1987) Proc. Natl. Acad. Sci. USA, 84, 1819-1823]. RNA binding as well as involvement in RNA processing has been demonstrated for some RRM proteins.
D T, Stolow, S R, Haynes
openaire   +3 more sources

Circadian rhythms of metabolite abundance in Drosophila are largely driven by time of feeding

The FEBS Journal, EarlyView.
Circadian clocks exist in the brain and peripheral tissues such as the Drosophila fat body. Single‐nuclei transcriptomics reveal that the fat body clock generates time‐of‐day differences in metabolic gene transcription, which may also be indirectly controlled by brain clocks.
Sumit Saurabh, Charlene Y. P. Guerrero, Madelyn R. Cusick, Amanda J. Samaras, Taylor M. Stephenson, Sebastian L. Kirkpatrick, Gregory J. Matthews, Daniel J. Cavanaugh   +7 more
wiley   +1 more source

Nutrient disturbance in a shallow aquaculture pond impacts Microcystis gene expression but does not impact bacterial community function during bloom conditions

Journal of Phycology, EarlyView.
Abstract Cyanobacterial harmful algal blooms (cHABs) are worldwide issues. Reduced nitrogen forms (ammonium and urea) have recently been measured in freshwater systems at concentrations not previously recorded. These reduced nitrogen forms have been shown to favor the proliferation of harmful cyanobacteria.
Matthew F. Gladfelter, Hunter R. Baylous, Alan E. Wilson, Morgan M. Steffen   +3 more
wiley   +1 more source

Transcriptome‐Based Classification of Resected Pancreatic Ductal Adenocarcinoma Enhances Prognostic Modelling Accuracy of Overall Survival Following Adjuvant Treatment

International Journal of Cancer, Volume 159, Issue 5, Page 1322-1336, 1 September 2026.
Outcomes after resection of pancreatic ductal adenocarcinoma remain highly variable, and existing prognostic models lack sufficient accuracy. Here, the authors aimed to improve survival prediction by integrating transcriptome‐based subtyping into a validated clinical model and applying it to a multicenter real‐world cohort of fresh‐frozen resection ...
Marjolein F. Lansbergen, Vincent R. Lanting, Paul Manoukian, Marc G. Besselink, Geert Kazemier, Ignace H. J. T. de Hingh, Mike S. L. Liem, Casper H. J. van Eijck, Erwin van der Harst, Vincent E. de Meijer, Ronald M. van Dam, Martijn W. J. Stommel, Jan Koster, Michael W. T. Tanck, Arantza Fariña Sarasqueta, Joanne Verheij, Frederike Dijk, Johanna W. Wilmink, Maarten F. Bijlsma, Hanneke W. M. van Laarhoven, for the Dutch Pancreatic Cancer Group   +20 more
wiley   +1 more source

Long‐Term Effects of a Dietary Humic Substance–Butyrate Blend, and Yeast Cell Wall on Growth Performance, Immune Status and Gut Microbiota of Juvenile Channel Catfish Ictalurus punctatus

Aquaculture, Fish and Fisheries, Volume 6, Issue 4, August 2026.
ABSTRACT This study evaluated the long‐term effects of a dietary humic substance and butyrate blend (HSB) alone or with yeast cell wall (Beta‐MOS) in channel catfish. Around 1440 fish (31.31 ± 0.24 g) were distributed among 12 outdoor tanks in a pond‐supplied flow‐through design. Four dietary treatments were evaluated in triplicate: Diets containing no
Abdulmalik A. Oladipupo, Anita M. Kelly, D. Allen Davis, Benjamin H. Beck, Luke A. Roy, Timothy J. Bruce   +5 more
wiley   +1 more source

Polyphenol oxidase depletion in Nicotiana benthamiana enhances recombinant protein purification and preserves native protein integrity

New Phytologist, Volume 251, Issue 3, Page 1283-1293, August 2026.
Polyphenol oxidases (PPOs) depletion preserves endogenous proteins at their predicted molecular weights and enhances detectable enzymatic activities. (a) Less RbcL crosslinking in ppo mutant of Nicotiana benthamiana. Leaf extracts were incubated for 1 h, separated on protein gels, stained with Coomassie or analyzed by Western blot with the anti‐RbcL ...
Kaijie Zheng, Farnusch Kaschani, Emma C. Watts, Markus Kaiser, Renier A. L. van der Hoorn   +4 more
wiley   +1 more source

Resveratrol Attenuates Obesity by Inducing GDF15 Expression via the p38‐ATF3 Signaling Pathway

Food Science &Nutrition, Volume 14, Issue 7, July 2026.
Resveratrol dose‐dependently upregulates GDF15 expression in murine and human cells via the p38‐ATF3 signaling axis. In high‐fat diet fed mice, resveratrol elevates systemic and tissue GDF15 levels, thereby reducing food intake and weight gain and conferring resistance to diet‐induced obesity. This study identifies a novel p38‐ATF3‐GDF15 axis mediating
Liufeng Mao, Yunliang Hou, Weifang Liu, Jianbin Chen, Wanli Hu, Wengong Jiang, Tao Nie   +6 more
wiley   +1 more source