Results 21 to 30 of about 5,120 (129)

Loci-specific phase separation of FET fusion oncoproteins promotes gene transcription

Nature Communications, 2021
FUS/EWS/TAF15 (FET) fusion oncoproteins contain low complexity domain which forms biomolecular condensates that recruit RNA polymerase II. Here the authors develop a single-molecule assay to visualize this phenomenon providing in vitro evidence to ...
Linyu Zuo, Guanwei Zhang, Matthew Massett, Jun Cheng, Zicong Guo, Liang Wang, Yifei Gao, Ru Li, Xu Huang, Pilong Li, Zhi Qi   +10 more
doaj   +1 more source

EWSR1-induced circNEIL3 promotes glioma progression and exosome-mediated macrophage immunosuppressive polarization via stabilizing IGF2BP3

Molecular Cancer, 2022
Background Gliomas are the most common malignant primary brain tumours with a highly immunosuppressive tumour microenvironment (TME) and poor prognosis.
Ziwen Pan, Rongrong Zhao, Boyan Li, Yanhua Qi, Wei Qiu, Qindong Guo, Shouji Zhang, Shulin Zhao, Hao Xu, Ming Li, Zijie Gao, Yang Fan, Jianye Xu, Huizhi Wang, Shaobo Wang, Jiawei Qiu, Qingtong Wang, Xing Guo, Lin Deng, Ping Zhang, Hao Xue, Gang Li   +21 more
doaj   +1 more source

Regulation of FAS Exon Definition and Apoptosis by the Ewing Sarcoma Protein

Cell Reports, 2014
The Ewing sarcoma protein EWS is an RNA and DNA binding protein implicated in transcription, pre-mRNA splicing, and DNA damage response. Using CLIP-seq, we identified EWS RNA binding sites in exonic regions near 5′ splice sites.
Maria Paola Paronetto, Isabella Bernardis, Elisabetta Volpe, Elias Bechara, Endre Sebestyén, Eduardo Eyras, Juan Valcárcel   +6 more
doaj   +1 more source

Phase separation of the oncogenic fusion protein EWS::FLI1 is modulated by its DNA-binding domain. [PDF]

Proc Natl Acad Sci U S A
Selig EE, Sohn EJ, Stoja A, Moreno-Romero AK, Akula S, Xu X, Bishop AJR, Libich DS.   +7 more
europepmc   +2 more sources

Functional Genomic Screening Reveals Splicing of the EWS-FLI1 Fusion Transcript as a Vulnerability in Ewing Sarcoma

Cell Reports, 2016
Ewing sarcoma cells depend on the EWS-FLI1 fusion transcription factor for cell survival. Using an assay of EWS-FLI1 activity and genome-wide RNAi screening, we have identified proteins required for the processing of the EWS-FLI1 pre-mRNA.
Patrick J. Grohar, Suntae Kim, Guillermo O. Rangel Rivera, Nirmalya Sen, Sara Haddock, Matt L. Harlow, Nichole K. Maloney, Jack Zhu, Maura O’Neill, Tamara L. Jones, Konrad Huppi, Magdalena Grandin, Kristen Gehlhaus, Carleen A. Klumpp-Thomas, Eugen Buehler, Lee J. Helman, Scott E. Martin, Natasha J. Caplen   +17 more
doaj   +1 more source

Locally advanced malignant solitary fibrous tumour successfully treated with conversion chemotherapy, operation and postoperative radiotherapy: a case report

Journal of International Medical Research, 2021
Preoperative diagnosis of solitary fibrous tumour (SFT) may not provide a complete tumour picture and may be inaccurate. There is no standard treatment for locally advanced or metastasised malignant SFT (MSFT).
Zhi-Ke Li, Jie Liu, Chen Chen, Ke-Yi Yang, Yao-Tiao Deng, Yu Jiang   +5 more
doaj   +1 more source

Gene expression responses to FUS, EWS, and TAF15 reduction and stress granule sequestration analyses identifies FET-protein non-redundant functions.

PLoS ONE, 2012
The FET family of proteins is composed of FUS/TLS, EWS/EWSR1, and TAF15 and possesses RNA- and DNA-binding capacities. The FET-proteins are involved in transcriptional regulation and RNA processing, and FET-gene deregulation is associated with ...
Jenny Blechingberg, Yonglun Luo, Lars Bolund, Christian Kroun Damgaard, Anders Lade Nielsen   +4 more
doaj   +1 more source

Identification of Tomato Proteins That Interact With Replication Initiator Protein (Rep) of the Geminivirus TYLCV

Frontiers in Plant Science, 2020
Geminiviruses are plant-infecting DNA viruses that reshape the intracellular environment of their host in order to create favorable conditions for viral replication and propagation.
Francesca Maio, Tieme A. Helderman, Manuel Arroyo-Mateos, Miguel van der Wolf, Sjef Boeren, Marcel Prins, Marcel Prins, Harrold A. van den Burg   +7 more
doaj   +1 more source

In-depth proteome analysis of brain tissue from Ewsr1 knockout mouse by multiplexed isobaric tandem mass tag labeling

Scientific Reports, 2023
EWS RNA binding protein 1 (EWSR1) is a multifunctional protein whose epigenetic signatures contribute to the pathogenesis of various human diseases, such as neurodegenerative disorders, skin development, and tumorigenic processes.
Jin Woo Jung, Hyeyoon Kim, Joonho Park, Jongmin Woo, Eunji Jeon, Geeeun Lee, Minseo Park, Sarang Kim, Hoseok Seo, Seongmin Cheon, Kisoon Dan, Junghee Lee, Hoon Ryu, Dohyun Han   +13 more
doaj   +1 more source

Long noncoding RNA EWSAT1-mediated gene repression facilitates Ewing sarcoma oncogenesis [PDF]

, 2014
Chromosomal translocation that results in fusion of the genes encoding RNA-binding protein EWS and transcription factor FLI1 (EWS-FLI1) is pathognomonic for Ewing sarcoma.
Crompton, Brian D, Zurab Siprashvili, David Simpson, Marcus R. Breese, Robert West, Mora, Jaume, Brian D. Crompton, Ngok, Siu P, Doug S. Hawkins, Nieves, Bethsaida, Stegmaier, Kimberly, Paul Khavari, Siu P. Ngok, Siprashvili, Zurab, Hawkins, Doug S, Gabriela Alexe, Brunner, Alayne L, Jaume Mora, Michelle Marques Howarth, Damon Jacobson, E. Alejandro Sweet-Cordero, Chen, Ron, West, Robert, Breese, Marcus R, Vaka, Dedeepya, Ron Chen, Jacobson, Damon, Khavari, Paul, Sweet-Cordero, E Alejandro, Dedeepya Vaka, Bethsaida Nieves, Alayne L. Brunner, Simpson, David, Howarth, Michelle Marques, Alexe, Gabriela, Kimberly Stegmaier   +35 more
core   +1 more source