Results 11 to 20 of about 5,120 (129)

Cloning and Mapping of a HumanRBP56Gene Encoding a Putative RNA Binding Protein Similar to FUS/TLS and EWS Proteins

Genomics, 1996
The EWS gene was found at the chromosome breakpoints in Ewing sarcoma, and the FUS/TLS gene was found at the breakpoints of myxoid liposarcoma and acute myeloid leukemia. These genes encode proteins that carry a highly homologous RNA binding domain. Fusion proteins made of the N-terminal half of EWS or FUS/TLS and transcriptional regulatory proteins ...
E Takahashi, A Tanigami
exaly   +3 more sources

A novel effector domain from the RNA-binding protein TLS or EWS is required for oncogenic transformation by CHOP.

Genes and Development, 1994
In human myxoid liposarcoma, a chromosomal rearrangement leads to fusion of the growth-arresting and DNA-damage-inducible transcription factor CHOP (GADD153) to a peptide fragment encoded by the TLS gene. We have found that wild-type TLS and a closely related sarcoma-associated protein, EWS, are both abundant nuclear proteins that associate in vivo ...
Ricard Albalat, David Ron
exaly   +3 more sources

Subversion of mRNA degradation pathways by EWSR1::FLI1 represents a therapeutic vulnerability in Ewing sarcoma [PDF]

Nature Communications
Many cancers are defined by gene fusions that frequently encode oncogenic transcription factors (TFs), such as EWSR1::FLI1 in Ewing sarcoma (EwS). Here, we report that independently to its canonical roles in transcription, EWSR1::FLI1 also functions as ...
Bartimée Galvan, Loïc Ongena, Jonathan Bruyr, Gregory Fettweis, Eva Lucarelli, Arnaud Lavergne, Emeline Mariavelle, Tina M. O’Grady, Zahrat El Oula Hassoun, Margaux Claes, Laurence Dubois, Kevin A. W. Lee, Véronique Kruys, Cyril Gueydan, Jules Durand, Eric Hervouet, Florian H. Geyer, Ana Banito, Roland Imle, Lianghao Mao, Ashok K. Jayavelu, Thomas G. P. Grünewald, Florencia Cidre-Aranaz, Jean-Claude Twizere, Franck Dequiedt   +24 more
doaj   +2 more sources

RNA-Binding Protein EWS [PDF]

, 2020
openaire   +2 more sources

Identification of an RNA-Binding-Protein-Based Prognostic Model for Ewing Sarcoma [PDF]

Cancers, 2021
RNA-binding proteins (RBPs) are important transcriptomic regulators and may be important in tumorigenesis. Here, we sought to investigate the clinical impact of RBPs for patients with Ewing sarcoma (ES). ES transcriptome signatures were characterized from four previously published cohorts and grouped into new training and validation cohorts. A total of
Yi Chen, Huafang Su, Yanhong Su, Yifan Zhang, Yingbo Lin, Felix Haglund   +5 more
openaire   +2 more sources

Overexpression of EWSR1 (Ewing sarcoma breakpoint region 1/EWS RNA binding protein 1) predicts poor survival in patients with hepatocellular carcinoma [PDF]

Bioengineered, 2021
Hepatocellular carcinoma (HCC) is one of the most prevalent malignant neoplasms with high relapse and mortality rate. It is of great importance to identify novel and effective molecular markers to predict prognosis for the treatment of HCC. The Ewing sarcoma breakpoint region 1 (EWSR1) gene is well known to fuse with various partner genes and involved ...
Jiang, Weijie, Wu, Tao, Shi, Xuan, Xu, Jiawen   +3 more
openaire   +2 more sources

Exploration of Flavonoids as Lead Compounds against Ewing Sarcoma through Molecular Docking, Pharmacogenomics Analysis, and Molecular Dynamics Simulations

Molecules, 2023
Ewing sarcoma (ES) is a highly malignant carcinoma prevalent in children and most frequent in the second decade of life. It mostly occurs due to t(11;22) (q24;q12) translocation.
Muhammad Yasir, Jinyoung Park, Eun-Taek Han, Won Sun Park, Jin-Hee Han, Yong-Soo Kwon, Hee-Jae Lee, Mubashir Hassan, Andrzej Kloczkowski, Wanjoo Chun   +9 more
doaj   +1 more source

Polymorphic variants of IGF2BP3 and SENCR have an impact on predisposition and/or progression of Ewing sarcoma

Frontiers in Oncology, 2022
Ewing sarcoma (EWS), the second most common malignant bone tumor in children and adolescents, occurs abruptly without clear evidence of tumor history or progression. Previous association studies have identified some inherited variants associated with the
Marcella Martinelli, Caterina Mancarella, Luca Scapoli, Annalisa Palmieri, Paola De Sanctis, Cristina Ferrari, Michela Pasello, Cinzia Zucchini, Katia Scotlandi   +8 more
doaj   +1 more source

SARS-CoV-2 helicase NSP13 hijacks the host protein EWSR1 to promote viral replication by enhancing RNA unwinding activity

Infectious Medicine, 2022
Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in December 2019 and has led to a global coronavirus disease 2019 (COVID-19) pandemic.
Hongxiang Zeng, Xiang Gao, Gang Xu, Shengyuan Zhang, Lin Cheng, Tongyang Xiao, Wenhong Zu, Zheng Zhang   +7 more
doaj   +1 more source

Ewing sarcoma from molecular biology to the clinic

Frontiers in Cell and Developmental Biology, 2023
In Europe, with an incidence of 7.5 cases per million, Ewing sarcoma (ES) is the second most common primary malignant bone tumor in children, adolescents and young adults, after osteosarcoma.
Maryne Dupuy, François Lamoureux, Mathilde Mullard, Anaïs Postec, Laura Regnier, Marc Baud’huin, Steven Georges, Bénédicte Brounais-Le Royer, Benjamin Ory, Françoise Rédini, Franck Verrecchia   +10 more
doaj   +1 more source