Results 1 to 10 of about 5,120 (129)

The cell cycle regulator CCDC6 is a key target of RNA-binding protein EWS. [PDF]

PLoS ONE, 2015
Genetic translocation of EWSR1 to ETS transcription factor coding region is considered as primary cause for Ewing sarcoma. Previous studies focused on the biology of chimeric transcription factors formed due to this translocation.
Sujitha Duggimpudi, Erik Larsson, Schafiq Nabhani, Arndt Borkhardt, Jessica I Hoell   +4 more
doaj   +6 more sources

The RNA binding protein EWS is broadly involved in the regulation of pri-miRNA processing in mammalian cells. [PDF]

Nucleic Acids Res, 2017
The Ewing Sarcoma protein (EWS) is a multifaceted RNA binding protein (RBP) with established roles in transcription, pre-mRNA processing and DNA damage response. By generating high quality EWS-RNA interactome, we uncovered its specific and prevalent interaction with a large subset of primary microRNAs (pri-miRNAs) in mammalian cells.
Ouyang H, Zhang K, Fox-Walsh K, Yang Y, Zhang C, Huang J, Li H, Zhou Y, Fu XD.   +8 more
europepmc   +8 more sources

Insights into Molecular Diversity within the FUS/EWS/TAF15 Protein Family: Unraveling Phase Separation of the N-Terminal Low-Complexity Domain from RNA-Binding Protein EWS. [PDF]

J Am Chem Soc
The FET protein family, comprising FUS, EWS, and TAF15, plays crucial roles in mRNA maturation, transcriptional regulation, and DNA damage response. Clinically, they are linked to Ewing family tumors and neurodegenerative diseases such as amyotrophic lateral sclerosis. The fusion protein EWS::FLI1, the causative mutation of Ewing sarcoma, arises from a
Johnson CN, Sojitra KA, Sohn EJ, Moreno-Romero AK, Baudin A, Xu X, Mittal J, Libich DS.   +7 more
europepmc   +5 more sources

Tyrosine kinase Pyk2 mediates G-protein-coupled receptor regulation of the Ewing sarcoma RNA-binding protein EWS [PDF]

Current Biology, 1999
Ewing family tumors result from the effects of chromosomal translocations that fuse the Ewing sarcoma (EWS) gene to various genes encoding transcription factors. The resulting chimeric EWS fusion proteins are transcriptional activators with transforming potential that have received much study.
William S Lane, Ernest G Peralta
exaly   +4 more sources

RNA-binding protein gene NOP58 exhibits crucial prognostic and therapeutic value in Ewing sarcoma [PDF]

Hereditas
Background Our aim was to identify crucial RNA-binding proteins (RBP) genes associated with Ewing sarcoma (EwS) in order to provide valuable insights into its mechanisms of tumorigenesis and to enhance therapeutic intervention.
Yannan Geng, Lu Yang, Rui Shao, Tiantong Xu, Lilong Zhang   +4 more
doaj   +4 more sources

The Spliceosomal Peptidyl Prolyl Isomerase Like 1 Interacts with the Low-Complexity Domain of the RNA Binding Protein EWS Modulating Its Phase Separation Behavior. [PDF]

Biochemistry
RNA binding protein EWS, a member of the FET (FUS, EWS, TAF15) family, contributes to mRNA biogenesis through roles in transcription, splicing, and RNA transport. Despite evidence linking EWS to spliceosomal complexes, its interactions with spliceosome-associated cyclophilins remain unclear.
Parra GL, Sohn EJ, Xu X, Libich DS.
europepmc   +5 more sources

Cutting Edge: The RNA-Binding Protein Ewing Sarcoma Is a Novel Modulator of Lymphotoxin β Receptor Signaling. [PDF]

J Immunol, 2020
Abstract Lymphotoxin β receptor (LTβR) signaling is crucial for lymphoid tissue organogenesis and immune homeostasis. To identify novel regulatory mechanisms for signaling, we implemented a two-step screen that uses coexpression analysis of human fibroblasts undergoing LTβR stimulation and affinity-purification mass spectrometry for the ...
Virgen-Slane R, Correa RG, Ramezani-Rad P, Steen-Fuentes S, Detanico T, DiCandido MJ, Li J, Ware CF.   +7 more
europepmc   +4 more sources

<i>O</i>-Linked-<i>N</i>-Acetylglucosaminylation of the RNA-Binding Protein EWS N-Terminal Low Complexity Region Reduces Phase Separation and Enhances Condensate Dynamics. [PDF]

J Am Chem Soc, 2021
Many membraneless organelles are thought to be biomolecular condensates formed by phase separation of proteins and other biopolymers. Post-translational modifications (PTMs) can impact protein phase separation behavior, although for many PTMs this aspect of their function is unknown.
Nosella ML, Tereshchenko M, Pritišanac I, Chong PA, Toretsky JA, Lee HO, Forman-Kay JD.   +6 more
europepmc   +3 more sources

Identification of Ewing’s sarcoma protein as a G‐quadruplex DNA‐ and RNA‐binding protein [PDF]

FEBS Journal, 2011
The Ewing’s sarcoma (EWS) oncogene contains an N‐terminal transcription activation domain and a C‐terminal RNA‐binding domain. Although the EWS activation domain is a potent transactivation domain that is required for the oncogenic activity of several EWS fusion proteins, the normal role of intact EWS is poorly characterized because little is known ...
Shigeki Arai, Riki Kurokawa, Takanori Oyoshi   +2 more
exaly   +3 more sources

Heterogeneous Folding Intermediates Govern the Conformational Pathway of the RNA Recognition Motif Domain of the Ewing Sarcoma Protein [PDF]

Biomolecules
The RNA Recognition Motif (RRM) domain of the Ewing sarcoma (EWS) protein plays a pivotal role in RNA binding and gene regulation, being crucial for its function. However, its structural dynamics are yet to be revealed.
Priyanka Kataria, Vishakha Chaudhary, Chandra Bhushan Mishra, Vijay Kumar, Ravi Datta Sharma, Amresh Prakash   +5 more
doaj   +2 more sources