Polyphenols as Potential Inhibitors of SARS-CoV-2 RNA Dependent RNA Polymerase (RdRp) [PDF]
Molecules, 2021 An increasing number of studies have demonstrated the antiviral nature of polyphenols, and many polyphenols have been proposed to inhibit SARS-CoV or SARS-CoV-2.
Yifei Wu +10 more
doaj +4 more sources
SARS-CoV-2 RNA Dependent RNA polymerase (RdRp) – A drug repurposing study [PDF]
Heliyon, 2020 The outbreak of SARS-CoV-2 in December 2019 in China subsequently lead to a pandemic. Lack of vaccine and specific anti-viral drugs started a global health disaster. For a sustained control and protection, development of potential anti-viral drugs is one
Jamshaid Ahmad +4 more
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RNA-dependent RNA polymerase (RdRp) natural antiviral inhibitors: a review [PDF]
Medicinal Chemistry Research, 2022 Viral diseases are the cause of many global epidemics, leading to deaths, affecting the quality of life of populations, and impairing public health. The limitations in the treatment of viral diseases and the constant resistance to conventional antiviral treatments encourage researchers to discover new compounds.
Daniela Regina Buch Leite +9 more
openaire +3 more sources
RNA dependent RNA polymerase (RdRp) as a drug target for SARS-CoV2 [PDF]
Journal of Biomolecular Structure and Dynamics, 2021 RNA-dependent RNA polymerase (RdRp), also called nsp12, is considered a promising but challenging drug target for inhibiting replication and hence, the growth of various RNA-viruses. In this report, a computational study is performed to offer insights on the binding of Remdesivir and Galidesivir with SARS-CoV2 RdRp with natural substrate, ATP, as the ...
Mishra, Avinash, Rathore, Anurag S.
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Identification of a New Drug Binding Site in the RNA-Dependent-RNA-Polymerase (RdRp) Domain
BioMedInformatics, 2023 We hypothesize that in silico structural biology approaches can discover novel drug binding sites for RNA-dependent-RNA-polymerases (RdRp) of positive sense single-strand RNA (ss(+)RNA) virus species.
Aparna S. Gana, James N. Baraniuk
doaj +2 more sources
Cordycepin as a Promising Inhibitor of SARS-CoV-2 RNA Dependent RNA Polymerase (RdRp)
Current Medicinal Chemistry, 2022 Background: SARS-CoV-2, which emerged in Wuhan, China, is a new global threat that has killed millions of people and continues to do so. This pandemic has not only threatened human life but has also triggered economic downturns across the world. Researchers have made significant strides in discovering molecular insights into SARSCoV- 2 pathogenesis ...
Shabana Bibi +4 more
+6 more sources
RNA-Dependent RNA Polymerase of the Second Human Pegivirus Exhibits a High-Fidelity Feature
Microbiology Spectrum, 2022 The virus-encoded RNA-dependent RNA polymerase (RdRp) is responsible for viral replication, and its fidelity is closely related to viral diversity, pathogenesis, virulence, and fitness.
Shuyi Chen +10 more
doaj +1 more source
Potential use of RNA-dependent RNA polymerase (RdRp) inhibitor against SARS-CoV2 infection [PDF]
All Life, 2020 Favipiravir, an inhibitor of RNA-dependent RNA polymerase used against the Japanese flu, was recently suggested as a potential COVID-19 inhibitor. Since Favipiravir targets a critical and a viral specific process, using it as a treatment could be beneficial in slowing the outbreak.
Charles Allen +3 more
openaire +2 more sources
Non-Nucleotide RNA-Dependent RNA Polymerase Inhibitor That Blocks SARS-CoV-2 Replication
Viruses, 2021 SARS-CoV-2 has caused an extensive pandemic of COVID-19 all around the world. Key viral enzymes are suitable molecular targets for the development of new antivirals against SARS-CoV-2 which could represent potential treatments of the corresponding ...
Milan Dejmek +9 more
doaj +1 more source
Mechanism of SARS-CoV-2 polymerase stalling by remdesivir
Nature Communications, 2021 Remdesivir is a nucleoside analog that inhibits the SARS-CoV-2 RNA dependent RNA polymerase (RdRp) and is used as a drug to treat COVID19 patients. Here, the authors provide insights into the mechanism of remdesivir-induced RdRp stalling by determining ...
Goran Kokic +9 more
doaj +1 more source