Potential RNA-dependent RNA polymerase (RdRp) inhibitors as prospective drug candidates for SARS-CoV-2 [PDF]
European Journal of Medicinal Chemistry, 2023 The SARS-CoV-2 pandemic is considered as one of the most disastrous pandemics for human health and the world economy. RNA-dependent RNA polymerase (RdRp) is one of the key enzymes that control viral replication. RdRp is an attractive and promising therapeutic target for the treatment of SARS-CoV-2 disease.
Mohamed S. Bekheit +2 more
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Covalent Inhibitors from Saudi Medicinal Plants Target RNA-Dependent RNA Polymerase (RdRp) of SARS-CoV-2 [PDF]
Viruses, 2023 COVID-19, a disease caused by SARS-CoV-2, has caused a huge loss of human life, and the number of deaths is still continuing. Despite the lack of repurposed drugs and vaccines, the search for potential small molecules to inhibit SARS-CoV-2 is in demand.
Ahmed H. Bakheit +5 more
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Screening of SARS-CoV-2 Antivirals Through a Cell-Based RNA-Dependent RNA Polymerase (RdRp) Reporter Assay [PDF]
Cell Insight, 2022 AbstractCOVID-19 (Coronavirus Disease 2019) caused by SARS-CoV-2 (Severe Acute Respiratory Syndrome CoronaVirus-2) continues to pose international public health threat and thus far, has resulted in greater than 5.6 million deaths worldwide. Vaccines are critical tools to limit COVID-19 spread, but antiviral drug development is an ongoing global ...
Timsy Uppal +5 more
europepmc +5 more sources
RNA‐dependent RNA polymerase, RdRP, a promising therapeutic target for cancer and potentially COVID‐19 [PDF]
Cancer Science, 2020 AbstractA recent outbreak of coronavirus disease (COVID‐19) caused by the novel severe acute respiratory syndrome coronavirus 2 has driven a global pandemic with catastrophic consequences. The rapid development of promising therapeutic strategies against COVID‐19 is keenly anticipated.
Machitani, Mitsuhiro +4 more
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Pharmacophore screening to identify natural origin compounds to target RNA-dependent RNA polymerase (RdRp) of SARS-CoV2 [PDF]
Molecular Diversity, 2022 Several existing drugs have gained initial consideration due to their therapeutic characteristics against COVID-19 (Corona Virus Disease 2019). Hydroxychloroquine (HCQ) was proposed as possible therapy for shortening the duration of COVID-19, but soon after this, it was discarded. Similarly, known antiviral compounds were also proposed and investigated
Avinash Mishra, Anurag S. Rathore
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Recent advances in the discovery of potent RNA-dependent RNA-polymerase (RdRp) inhibitors targeting viruses [PDF]
RSC Medicinal Chemistry, 2021 This review summarizes the latest advances in the RNA-dependent RNA polymerase (RdRp) inhibitors targeting various viruses.
Rahul Kumar +3 more
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A computational approach to drug repurposing against SARS-CoV-2 RNA dependent RNA polymerase (RdRp) [PDF]
Journal of Biomolecular Structure and Dynamics, 2020 The spread of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) caused a worldwide outbreak of coronavirus disease 19 (COVID-19), which rapidly evolved as a global concern. The efforts of the scientific community are pointed towards the identification of promptly available therapeutic options.
Ribaudo, Giovanni +5 more
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SARS-CoV-2 RNA dependent RNA polymerase (RdRp) targeting: anin silicoperspective [PDF]
Journal of Biomolecular Structure and Dynamics, 2020 New treatment against SARS-CoV-2 now is a must. Nowadays, the world encounters a huge health crisis by the COVID-19 viral infection. Nucleotide inhibitors gave a lot of promising results in terms of its efficacy against different viral infections. In this work, molecular modeling, docking, and dynamics simulations are used to build a model for the ...
Elfiky AA.
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RNA-dependent RNA polymerase (RdRp) inhibitors: The current landscape and repurposing for the COVID-19 pandemic [PDF]
European Journal of Medicinal Chemistry, 2021 The widespread nature of several viruses is greatly credited to their rapidly altering RNA genomes that enable the infection to persist despite challenges presented by host cells. Within the RNA genome of infections is RNA-dependent RNA polymerase (RdRp), which is an essential enzyme that helps in RNA synthesis by catalysing the RNA template-dependent ...
Tian, Lei +11 more
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Mechanistic insight on the remdesivir binding to RNA-Dependent RNA polymerase (RdRp) of SARS-cov-2 [PDF]
Computers in Biology and Medicine, 2021 The RNA-dependent RNA polymerase (RdRp) is a key enzyme which regulates the viral replication of SARS-CoV-2. Remdesivir (RDV) is clinically used drug which targets RdRp, however its mechanism of action remains elusive. This study aims to find out the binding dynamics of active Remdesivir-triphosphate (RDV-TP) to RdRp by means of molecular dynamics (MD)
Arba, Muhammad +4 more
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