Results 41 to 50 of about 22,843 (140)
FEBS Open Bio, 2014 Identification of viral encoded proteins that interact with RNA-dependent RNA polymerase (RdRp) is an important step towards unraveling the mechanism of replication.
Kunduri Govind +2 more
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Development and validation of RdRp Screen, a crystallization screen for viral RNA-dependent RNA polymerases [PDF]
Biology Open, 2019 ABSTRACT Members of the Flaviviridae family constitute a severe risk to human health. Whilst effective drugs have been developed against the hepacivirus HCV, no antiviral therapy is currently available for any other viruses, including the flaviviruses dengue (DENV), West Nile and Zika viruses.
Federica Riccio +5 more
openaire +5 more sources
PLoS Pathogens, 2021 Morbilliviruses, such as measles virus (MeV) and canine distemper virus (CDV), are highly infectious members of the paramyxovirus family. MeV is responsible for major morbidity and mortality in non-vaccinated populations.
Robert M Cox +4 more
doaj +1 more source
Saudi Pharmaceutical Journal, 2020 Zika virus (ZIKV) is one of the mosquito borne flavivirus with several outbreaks in past few years in tropical and subtropical regions. The non-structural proteins of flaviviruses are suitable active targets for inhibitory drugs due to their role in ...
Noreen +10 more
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RNA-DEPENDENT RNA POLYMERASE (RDRP) INHIBITOR DRUGS AGAINST SARS-COV-2: A MOLECULAR DOCKING STUDY
Ankara Universitesi Eczacilik Fakultesi Dergisi, 2022 Amaç: SARS-CoV-2 ile ilişkili viral pandemisi ilk olarak Aralık 2019'da Çin'in Wuhan kentinde bildirilmiştir. enfeksiyon gücünün yüksek olması nedeniyle, Dünya Sağlık Örgütü (DSÖ) 11 Mart 2020 tarihinde SARS-CoV-2’yi küresel pandemi olarak ilan etmiştir. Bu nedenle en önemli viral protein hedeflerinin belirlenmesi bir zorunluluk haline geldi.
GADO, Sarah, ALAGÖZ, Zeynep
openaire +4 more sources
Frontiers in Genetics, 2020 BackgroundRNA-dependent RNA polymerase (RdRp) is the key enzyme responsible for the SARS-CoV-2 replication process and catalyzes the synthesis of complementary minus strand RNA and genomic plus strand RNA, often recognized as good targets for antiviral ...
Shuang Ao +8 more
doaj +1 more source
Structure and Function of Caliciviral RNA Polymerases
Viruses, 2017 Caliciviruses are a leading agent of human and animal gastroenteritis and respiratory tract infections, which are growing concerns in immunocompromised individuals. However, no vaccines or therapeutics are yet available.
Ji-Hye Lee +2 more
doaj +1 more source
Expression and purification of tag-free SARS-CoV-2 RNA-dependent RNA polymerase in Escherichia coli
STAR Protocols, 2021 Summary: The RNA-dependent-RNA polymerase (RdRp) from SARS-CoV-2 is an important drug target because it is responsible for viral RNA genome replication. Efficient production of recombinant RdRp is important in screening antivirals to treat COVID-19. Here,
Tyler L. Dangerfield +2 more
doaj +1 more source
Dual Role of a Viral Polymerase in Viral Genome Replication and Particle Self-Assembly
mBio, 2018 Double-stranded RNA (dsRNA) viruses package several RNA-dependent RNA polymerases (RdRp) together with their dsRNA genome into an icosahedral protein capsid known as the polymerase complex.
Xiaoyu Sun +3 more
doaj +1 more source
use of RNA-dependent RNA polymerase (RdRp) inhibitors against SARS-CoV2 infection
, 2020 We described the importance of developing a vaccine against RdRp and discussed Favipiravir and ...
Chales Allen, +3 more
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