Results 21 to 30 of about 28,766 (215)
Pharmaceutics, 2023 The development of effective anti-cancer therapeutics remains one of the current pharmaceutical challenges. The joint delivery of chemotherapeutic agents and biopharmaceuticals is a cutting-edge approach to creating therapeutic agents of enhanced ...
Apollinariia Dzhuzha +7 more
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RNA methyltransferases involved in 5′ cap biosynthesis [PDF]
RNA Biology, 2014 In eukaryotes and viruses that infect them, the 5' end of mRNA molecules, and also many other functionally important RNAs, are modified to form a so-called cap structure that is important for interactions of these RNAs with many nuclear and cytoplasmic proteins.
Byszewska M +3 more
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Viruses, 2020 The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) causing the COVID-19 respiratory disease pandemic utilizes unique 2′-O-methyltransferase (2′-O-MTase) capping machinery to camouflage its RNA from innate immune recognition.
José Antonio Encinar +1 more
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Deciphering the RNA capping process in bacteria [PDF]
Proceedings of the National Academy of Sciences, 2020 RNA capping in eukaryotes has been studied since the 1970s, starting with the discovery of 5′ 7-methylguanylate caps in the Shatkin laboratory (1). That capping mechanism involves a pause during transcription elongation that allows the recruitment of specialized capping enzymes to modify the 5′ end of the nascent RNA.
Jonathan, Jagodnik, Richard L, Gourse
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Extensive 5′-surveillance guards against non-canonical NAD-caps of nuclear mRNAs in yeast
Nature Communications, 2020 NAD (nicotinamide adenine dinucleotide) acts as a non-canonical RNA cap structure in bacteria and eukaryotes. Here the authors demonstrate the whole landscape of budding yeast NAD-RNAs which are subject to diverse surveillance pathways, suggesting that ...
Yaqing Zhang +9 more
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Cell Death Discovery, 2022 7-methylguanosine (m7G) modification is recently found to conservatively exist in RNA internal position besides mRNA caps and mediates the various RNA metabolisms.
Haiyun Xie +13 more
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RNA capping by mitochondrial and multi-subunit RNA polymerases [PDF]
Transcription, 2018 Recently, it was found that bacterial and eukaryotic transcripts are capped with cellular cofactors installed by their respective RNA polymerases (RNAPs) during transcription initiation. We now show that mitochondrial RNAP efficiently caps transcripts with ADP - containing cofactors.
Christina Julius +2 more
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RNA capping: progress and prospects [PDF]
RNA, 2015 The 5′ m7GpppN cap, co-discovered by Shatkin, Furuichi, and Moss in 1975, is the signature feature of eukaryal cellular and viral messenger RNA that confers mRNA stability and efficient translation. Cap formation entails three sequential enzymatic modifications targeted to nascent pre-mRNAs synthesized by cellular or viral RNA polymerases. First, the 5′
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Metabolites, 2022 Salt-induced renal metabolism dysfunction is an important mechanism of salt-sensitive hypertension. Given that the gut-liver axis is the first hit of a high-salt diet (HSD), we aimed to identify the extra-renal mechanism from hepatic metabolism and gut ...
Ya-nan Ou-Yang +5 more
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Helix Capping in RNA Structure
PLoS ONE, 2014 Helices are an essential element in defining the three-dimensional architecture of structured RNAs. While internal basepairs in a canonical helix stack on both sides, the ends of the helix stack on only one side and are exposed to the loop side, thus susceptible to fraying unless they are protected.
Lee, Jung C., Gutell, Robin R.
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