Adenovirus type 5 E4 Orf3 protein targets promyelocytic leukaemia (PML) protein nuclear domains for disruption via a sequence in PML isoform II that is predicted as a protein interaction site by bioinformatic analysis [PDF]
, 2009 Human adenovirus type 5 infection causes the disruption of structures in the cell nucleus termed promyelocytic leukaemia (PML) protein nuclear domains or ND10, which contain the PML protein as a critical component. This disruption is achieved through the
Araujo +37 more
core +1 more source
3′-UTR engineering to improve soluble expression and fine-tuning of activity of cascade enzymes in Escherichia coli [PDF]
3'-Untranslated region (3'UTR) engineering was investigated to improve solubility of heterologous proteins (e.g., Baeyer-Villiger monooxygenases (BVMOs)) in Escherichia coli.
Bornscheuer, UT +4 more
core +1 more source
Short RNA half-lives in the slow-growing marine cyanobacterium Prochlorococcus [PDF]
, 2010 Background: RNA turnover plays an important role in the gene regulation of microorganisms and influences their speed of acclimation to environmental changes.
Claudia Steglich +5 more
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When translation elongation is impaired, the mRNA is uniformly destabilized by the RNA degradosome, while the concentration of mRNA is altered along the molecule. [PDF]
Nucleic Acids Res, 2023 Duviau MP +5 more
europepmc +1 more source
Omnipresent Maxwell’s demons orchestrate information management in living cells [PDF]
, 2019 The development of synthetic biology calls for accurate understanding of the critical functions that allow construction and operation of a living cell.
Danchin, Antoine +1 more
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, 2013 Campylobacter jejuni is the leading cause of human bacterial gastroenteritis worldwide, but source attribution of the organism is difficult. Previously, DNA microarrays were used to investigate isolate source, which suggested a non-livestock source of ...
Altschul +55 more
core +1 more source
Rapidly Characterizing the Fast Dynamics of RNA Genetic Circuitry with Cell-Free Transcription Translation (TX-TL) Systems [PDF]
, 2015 RNA regulators are emerging as powerful tools to engineer synthetic genetic networks or rewire existing ones. A potential strength of RNA networks is that they may be able to propagate signals on time scales that are set by the fast degradation rates of ...
Al-Khabouri, Shaima +11 more
core +4 more sources
Single molecule/particle tracking analysis program SMTracker 2.0 reveals different dynamics of proteins within the RNA degradosome complex in Bacillus subtilis. [PDF]
Nucleic Acids Res, 2021 Oviedo-Bocanegra LM +4 more
europepmc +1 more source
Tissue- and Species-Specific Patterns of RNA metabolism in Post-Mortem Mammalian Retina and Retinal Pigment Epithelium. [PDF]
, 2019 Accurate analysis of gene expression in human tissues using RNA sequencing is dependent on the quality of source material. One major source of variation in mRNA quality is post-mortem time.
Blackshaw, Seth +3 more
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