Results 251 to 260 of about 685,668 (343)

Injectable Dual‐Network Hydrogel System for Osteochondral Repair Combining Immunomodulation, Mechanical Adaptability, and Enhanced Tissue Integration

Advanced Functional Materials, EarlyView.
A UV‐triggered injectable dual‐network hydrogel is reported as the first application of bletilla striata polysaccharide (BSP) in osteochondral repair. By integrating methacrylamide‐modified BSP and nitrobenzaldehyde‐functionalized hyaluronic acid, the system achieves immunomodulation, mechanical reinforcement, and dynamic tissue adhesion, thereby ...
Jiaming Cui, Feifei Zhou, Yuan Luo, Tao Ouyang, Huiwu Zhang, Songmiao Cheng, Qiang Li, Xu Jiang, Yingying Yu, Yicheng Wang, Hong Ming   +10 more
wiley   +1 more source

Evaluation of in vitro liver models and non-human primates for predicting ADAR RNA editing efficiency in human liver. [PDF]

Sci Rep
Aguila M, Cnubben NHP, Parfitt DA, Albuquerque B, de Visser PC, Molendijk M, Marques L, van Berkel M, Platenburg GJ.   +8 more
europepmc   +1 more source

MagPiezo: A Magnetogenetic Platform for Remote Activation of Endogenous Piezo1 Channels in Endothelial Cells

Advanced Functional Materials, EarlyView.
MagPiezo enables wireless activation of endogenous Piezo1 channels without genetic modification using 19 nm magnetic nanoparticles and low‐intensity magnetic fields. It generates torque forces at the piconewton scale to trigger mechanotransduction in endothelial cells, standing as a novel platform to interrogate and manipulate Piezo1 activity in vitro.
Susel Del Sol‐Fernández, Mariarosaria De Simone, Yilian Fernández‐Afonso, Daniel Garcia‐Gonzalez, Pablo Martínez‐Vicente, Thomas van Zanten, Raluca M. Fratila, Maria Moros   +7 more
wiley   +1 more source

Emerging clinical applications of ADAR based RNA editing. [PDF]

Stem Cells Transl Med
Rainaldi J, Mali P, Nourreddine S.
europepmc   +1 more source

AI and RNA editing blood biomarkers to differentiate bipolar disorder from major depressive disorder

Dinah Weissmann, Nicolas Salvetat, Francisco Jesus Checa-Robles, Mary Menhem, Aurelie Delacretaz, Christopher Cayzac, Benjamin Dubuc, Diana Vetter, Jean-Philippe Lang, F. Gamma   +9 more
openalex   +1 more source

Self-cleaving ribozymes enable the production of guide RNAs from unlimited choices of promoters for CRISPR/Cas9 mediated genome editing

, 2017
Yubing He, Tao Zhang, Ning Yang, Meilian Xu, Lang Yan, Lihao Wang, Rongchen Wang, Yunde Zhao   +7 more
openalex   +2 more sources

Poly(lactic‐co‐glycolic acid) Nanoparticles for IL‐12 Self‐Amplifying RNA Delivery in Glioblastoma Models

Advanced Functional Materials, EarlyView.
xxxx. ABSTRACT Glioblastoma (GBM) remains one of the most lethal brain cancers, with median survival rarely exceeding 15 months after diagnosis. Interleukin‐12 (IL‐12) is a potent immunostimulatory cytokine capable of reshaping the tumor microenvironment (TME), yet its clinical translation is hindered by systemic toxicity and short half‐life. RNA‐based
Fatima Hameedat, Johan Sebastian Lopez‐Parra, Willem M. H. Hoogaars, Emma Dijkstra, Cynthia Huang, Irafasha C. Casmil, Anna K. Blakney, Peter Olinga, Barbara Rothen‐Rutishauser, Hélder A. Santos, Alke Petri‐Fink, Flávia Sousa   +11 more
wiley   +1 more source

In-depth analysis of the RNA editing landscape in intracranial aneurysms and its potential role in alternative splicing. [PDF]

Comput Struct Biotechnol J
Wang Y, Li Q, Wang P, Xu T, Zhao X, Ye M.   +5 more
europepmc   +1 more source

Tissue Engineered Human Elastic Cartilage From Primary Auricular Chondrocytes for Ear Reconstruction

Advanced Functional Materials, EarlyView.
Despite over three decades of research, no tissue‐engineered solution for auricular reconstruction in microtia patients has reached clinical translation. The key challenge lies in generating functional elastic cartilage ex vivo. Here, we integrate synergistic cell‐biomaterial strategies to engineer auricular grafts with mechanical and histological ...
Philipp Fisch, Sandra Kessler, Simone Ponta, Anna Puiggalí‐Jou, Guoliang Lyu, Killian Flégeau, Anastasiya Martyts, Florian Roth, David Fercher, Filippo M. Rijli, Daniel Simmen, Eva Novoa Olivares, Thomas Linder, Marcy Zenobi‐Wong   +13 more
wiley   +1 more source

SlPPR138-mediated RNA editing of <i>rpoC1</i> is essential for chloroplast development in tomato. [PDF]

Hortic Res
Liu Y, Li C, Si X, Zou T, Li Y, Pan C, Lu G.   +6 more
europepmc   +1 more source