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Modeling recursive RNA interference. [PDF]
PLoS Computational Biology, 2008 An important application of the RNA interference (RNAi) pathway is its use as a small RNA-based regulatory system commonly exploited to suppress expression of target genes to test their function in vivo.
Wallace F Marshall
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Specific and heritable genetic interference by double-stranded RNA in Arabidopsis thaliana [PDF]
, 2000 We investigated the potential of double-stranded RNA interference (RNAi) with gene activity in Arabidopsis thaliana. To construct transformation vectors that produce RNAs capable of duplex formation, gene-specific sequences in the sense and antisense ...
Chiou‐Fen Chuang, Elliot M. Meyerowitz
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RNA interference approaches for treatment of HIV-1 infection. [PDF]
Genome Medicine, 2015 HIV/AIDS is a chronic and debilitating disease that cannot be cured with current antiretroviral drugs. While combinatorial antiretroviral therapy (cART) can potently suppress HIV-1 replication and delay the onset of AIDS, viral mutagenesis often leads to
Bobbin, Maggie L +2 more
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Symbiont-mediated RNA interference in insects [PDF]
Proceedings of the Royal Society B: Biological Sciences, 2016 RNA interference (RNAi) methods for insects are often limited by problems with double-stranded (ds) RNA delivery, which restricts reverse genetics studies and the development of RNAi-based biocides. We therefore delegated to insect symbiotic bacteria the
Bodger, Owen G. +7 more
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CRISPR-Cas13d mediates robust RNA virus interference in plants
Genome Biology, 2019 Background CRISPR-Cas systems endow bacterial and archaeal species with adaptive immunity mechanisms to fend off invading phages and foreign genetic elements.
Ahmed Mahas, Rashid Aman, Magdy Mahfouz
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Conditional RNA interference in mammalian cells via RNA transactivation [PDF]
Nature CommunicationsRNA interference (RNAi) is a powerful tool for sequence-specific gene knockdown in therapeutic and research applications. However, spatiotemporal control of RNAi is required to decrease nonspecific targeting, potential toxicity, and allow targeting of ...
Yu Zhou +5 more
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RNA virus interference via CRISPR/Cas13a system in plants
Genome Biology, 2018 Background CRISPR/Cas systems confer immunity against invading nucleic acids and phages in bacteria and archaea. CRISPR/Cas13a (known previously as C2c2) is a class 2 type VI-A ribonuclease capable of targeting and cleaving single-stranded RNA (ssRNA ...
Rashid Aman +7 more
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Microorganisms, 2021 Palm Creek virus (PCV) is an insect-specific flavivirus that can interfere with the replication of mosquito-borne flaviviruses in Culex mosquitoes, thereby potentially reducing disease transmission.
Cassandra Koh +3 more
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Zilebesiran, an RNA Interference Therapeutic Agent for Hypertension.
New England Journal of Medicine, 2023 BACKGROUND Angiotensinogen is the sole precursor of angiotensin peptides and has a key role in the pathogenesis of hypertension. Zilebesiran, an investigational RNA interference therapeutic agent with a prolonged duration of action, inhibits hepatic ...
Akshay S. Desai +10 more
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Genes and Mechanisms Related to RNA Interference Regulate Expression of the Small Temporal RNAs that Control C. elegans Developmental Timing [PDF]
Cell, 2001 Alla Grishok +9 more
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