Results 11 to 20 of about 2,276,335 (391)
The RNA interference revolution [PDF]
Brazilian Journal of Medical and Biological Research, 2005 The discovery of double-stranded RNA-mediated gene silencing has rapidly led to its use as a method of choice for blocking a gene, and has turned it into one of the most discussed topics in cell biology.
G. Lenz
doaj +6 more sources
Branched RNA: A New Architecture for RNA Interference [PDF]
Journal of Nucleic Acids, 2011 Branched RNAs with two and four strands were synthesized. These structures were used to obtain branched siRNA. The branched siRNA duplexes had similar inhibitory capacity as those of unmodified siRNA duplexes, as deduced from gene silencing experiments ...
Anna Aviñó +3 more
doaj +5 more sources
Transfer RNA and Origins of RNA Interference [PDF]
Frontiers in Molecular Biosciences, 2021 Almost 30 years ago the first microRNA (miRNA) was detected (Lee et al., 1993), later put in mechanistical context by the discovery of the RNA interference (RNAi) and RNA-induced silencing complex (RISC). miRNA is the variable RISC element (guide) that recognizes messenger RNA (mRNA) targets in the RNAi process facilitated by Argonaute (Ago) proteins ...
Andrey Grigoriev
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Using RNA interference to identify genes required for RNA interference [PDF]
Proceedings of the National Academy of Sciences, 2002 RNA interference (RNAi) is a phenomenon in which double-stranded RNA (dsRNA) silences endogenous gene expression. By injecting pools of dsRNAs into Caenorhabditis elegans , we identified a dsRNA that acts as a potent suppressor of the RNAi mechanism.
N. R. Dudley, J.-C. Labbe, B. Goldstein
+7 more sources
Combined VEGFR and MAPK pathway inhibition in angiosarcoma
Scientific Reports, 2021 Angiosarcoma is an aggressive malignancy of endothelial cells that carries a high mortality rate. Cytotoxic chemotherapy can elicit clinical responses, but the duration of response is limited.
Michael J. Wagner +12 more
doaj +1 more source
eLife, 2023 Total RNA sequencing (RNA-seq) is an important tool in the study of mosquitoes and the RNA viruses they vector as it allows assessment of both host and viral RNA in specimens. However, there are two main constraints.
Cassandra Koh +9 more
doaj +1 more source
Strategies for Enhancing the Efficiency of RNA Interference in Insects.
Pest Management Science, 2021 Low RNA interference (RNAi) efficiency in many insect pests has significantly prevented its widespread application for insect pest management. This article provides a comprehensive review on recent research in developing various strategies for enhancing ...
K. Silver, Anastasia M W Cooper, K. Zhu
semanticscholar +1 more source
RNA Interference in Ticks [PDF]
Journal of Visualized Experiments, 2011 Ticks are obligate hematophagous ectoparasites of wild and domestic animals and humans, and are considered to be second worldwide to mosquitoes as vectors of human diseases(1) and the most important vectors affecting cattle industry worldwide(2). Ticks are classified in the subclass Acari, order Parasitiformes, suborder Ixodida and are distributed ...
José de la Fuente +3 more
openaire +5 more sources
RNA interference of gonadotropin-inhibitory hormone gene induces arousal in songbirds. [PDF]
, 2012 Gonadotropin-inhibitory hormone (GnIH) was originally identified in quail as a hypothalamic neuropeptide inhibitor of pituitary gonadotropin synthesis and release.
Bentley, George E +13 more
core +15 more sources