Results 11 to 20 of about 2,067,543 (238)
Conditional RNA interference in mammalian cells via RNA transactivation [PDF]
Nature CommunicationsRNA interference (RNAi) is a powerful tool for sequence-specific gene knockdown in therapeutic and research applications. However, spatiotemporal control of RNAi is required to decrease nonspecific targeting, potential toxicity, and allow targeting of ...
Yu Zhou +5 more
doaj +2 more sources
RNA virus interference via CRISPR/Cas13a system in plants
Genome Biology, 2018 Background CRISPR/Cas systems confer immunity against invading nucleic acids and phages in bacteria and archaea. CRISPR/Cas13a (known previously as C2c2) is a class 2 type VI-A ribonuclease capable of targeting and cleaving single-stranded RNA (ssRNA ...
Rashid Aman +7 more
doaj +2 more sources
CRISPR-Cas13d mediates robust RNA virus interference in plants
Genome Biology, 2019 Background CRISPR-Cas systems endow bacterial and archaeal species with adaptive immunity mechanisms to fend off invading phages and foreign genetic elements.
Ahmed Mahas, Rashid Aman, Magdy Mahfouz
doaj +2 more sources
Genes and Mechanisms Related to RNA Interference Regulate Expression of the Small Temporal RNAs that Control C. elegans Developmental Timing [PDF]
Cell, 2001 A. Grishok +9 more
semanticscholar +2 more sources
Zilebesiran, an RNA Interference Therapeutic Agent for Hypertension.
New England Journal of Medicine, 2023 BACKGROUND Angiotensinogen is the sole precursor of angiotensin peptides and has a key role in the pathogenesis of hypertension. Zilebesiran, an investigational RNA interference therapeutic agent with a prolonged duration of action, inhibits hepatic ...
Akshay S. Desai +10 more
semanticscholar +1 more source
Strategies for Enhancing the Efficiency of RNA Interference in Insects.
Pest Management Science, 2021 Low RNA interference (RNAi) efficiency in many insect pests has significantly prevented its widespread application for insect pest management. This article provides a comprehensive review on recent research in developing various strategies for enhancing ...
K. Silver, Anastasia M W Cooper, K. Zhu
semanticscholar +1 more source
Mechanisms, Applications, and Challenges of Insect RNA Interference.
Annual Review of Entomology, 2020 The RNA interference (RNAi) triggered by short/small interfering RNA (siRNA) was discovered in nematodes and found to function in most living organisms.
K. Zhu, S. R. Palli
semanticscholar +1 more source
Hepatology, 2020 ARC‐520, the first an RNA interference (RNAi) therapeutic, was designed to reduce all RNA transcripts derived from covalently closed circular DNA, leading to a reduction in viral antigens and hepatitis B virus (HBV) DNA.
M. Yuen +17 more
semanticscholar +1 more source
Key Mechanistic Principles and Considerations Concerning RNA Interference
Frontiers in Plant Science, 2020 Canonical RNAi, one of the so-called RNA-silencing mechanisms, is defined as sequence-specific RNA degradation induced by long double-stranded RNA (dsRNA).
P. Svoboda
semanticscholar +1 more source
RNA interference and Register Machines (extended abstract) [PDF]
EPTCS 100, 2012, pp. 107-112, 2012 RNA interference (RNAi) is a mechanism whereby small RNAs (siRNAs) directly control gene expression without assistance from proteins. This mechanism consists of interactions between RNAs and small RNAs both of which may be single or double stranded. The target of the mechanism is mRNA to be degraded or aberrated, while the initiator is double stranded ...
arxiv +1 more source