Results 21 to 30 of about 2,067,543 (238)

RNA interference is mediated by 21- and 22-nucleotide RNAs.

Genes & Development, 2001
Double-stranded RNA (dsRNA) induces sequence-specific posttranscriptional gene silencing in many organisms by a process known as RNA interference (RNAi). Using a Drosophila in vitro system, we demonstrate that 21- and 22-nt RNA fragments are the sequence-
Sayda M. Elbashir, Winfried Lendeckel, T. Tuschl   +2 more
semanticscholar   +1 more source

Quantitative analysis of competition in post-transcriptional regulation reveals a novel signature in target expression variation [PDF]

Biophysical Journal, 104 (4), 951-958 (2013), 2012
When small RNAs are loaded onto Argonaute proteins they can form the RNA-induced silencing complexes (RISCs), which mediate RNA interference. RISC-formation is dependent on a shared pool of Argonaute proteins and RISC loading factors, and is thus susceptible to competition among small RNAs for loading.
arxiv   +1 more source

Modeling and Optimization of Genetic Screens via RNA Interference and FACS [PDF]

Prob. Eng. Inf. Sci. 29 (2015) 131-145, 2014
We study mathematically a method for discovering which gene is related to a cell phenotype of interest. The method is based on RNA interference -- a molecular process for gene deactivation -- and on coupling the phenotype with fluorescence in a FACS machine. A small number of candidate genes are thus isolated, and then tested individually.
arxiv   +1 more source

Mathematical model of plant-virus interactions mediated by RNA interference [PDF]

J. Theor. Biol. 403, 129-142 (2016), 2016
Cross-protection, which refers to a process whereby artificially inoculating a plant with a mild strain provides protection against a more aggressive isolate of the virus, is known to be an effective tool of disease control in plants. In this paper we derive and analyse a new mathematical model of the interactions between two competing viruses with ...
arxiv   +1 more source

Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1

Nature, 2009
The proto-oncogene KRAS is mutated in a wide array of human cancers, most of which are aggressive and respond poorly to standard therapies. Although the identification of specific oncogenes has led to the development of clinically effective, molecularly ...
D. Barbie, P. Tamayo, J. Boehm, S. Kim, S. Moody, I. Dunn, Anna C. Schinzel, P. Sandy, E. Meylan, C. Scholl, S. Fröhling, Edmond M. Chan, M. Sos, K. Michel, C. Mermel, S. Silver, B. Weir, J. Reiling, Qing Sheng, Piyush B. Gupta, R. Wadlow, R. Wadlow, Hanh Le, S. Hoersch, Ben S. Wittner, Ben S. Wittner, Sridhar Ramaswamy, Sridhar Ramaswamy, D. Livingston, D. Sabatini, M. Meyerson, M. Meyerson, Roman K. Thomas, E. Lander, J. Mesirov, D. Root, D. Gilliland, T. Jacks, W. Hahn   +38 more
semanticscholar   +1 more source

Phase 1 Trial of an RNA Interference Therapy for Acute Intermittent Porphyria

New England Journal of Medicine, 2019
BACKGROUND Induction of delta aminolevulinic acid synthase 1 (ALAS1) gene expression and accumulation of neurotoxic intermediates result in neurovisceral attacks and disease manifestations in patients with acute intermittent porphyria, a rare inherited ...
Eliane Sardh, P. Harper, M. Balwani, P. Stein, D. Rees, Montgomery Bissell, R. Desnick, C. Parker, J. Phillips, H. Bonkovsky, Daphne Vassiliou, C. Penz, Amy Chan‐Daniels, Qiuling He, W. Querbes, K. Fitzgerald, Jae B. Kim, P. Garg, A. Vaishnaw, A. Simon, K. Anderson   +20 more
semanticscholar   +1 more source

A genome‐scale screen reveals context‐dependent ovarian cancer sensitivity to miRNA overexpression

Molecular Systems Biology, 2015
Large‐scale molecular annotation of epithelial ovarian cancer (EOC) indicates remarkable heterogeneity in the etiology of that disease. This diversity presents a significant obstacle against intervention target discovery.
Benjamin B Shields, Chad V Pecot, Hua Gao, Elizabeth McMillan, Malia Potts, Christa Nagel, Scott Purinton, Ying Wang, Cristina Ivan, Hyun Seok Kim, Robert J Borkowski, Shaheen Khan, Cristian Rodriguez‐Aguayo, Gabriel Lopez‐Berestein, Jayanthi Lea, Adi Gazdar, Keith A Baggerly, Anil K Sood, Michael A White   +18 more
doaj   +1 more source

Time-delayed model of RNA interference [PDF]

Ecol. Compl. 30, 11-25 (2017), 2016
RNA interference (RNAi) is a fundamental cellular process that inhibits gene expression through cleavage and destruction of target mRNA. It is responsible for a number of important intracellular functions, from being the first line of immune defence against pathogens to regulating development and morphogenesis.
arxiv   +1 more source

Genetically Modified Organism-Free RNA Interference: Exogenous Application of RNA Molecules in Plants1[OPEN]

Plant Physiology, 2019
The latest advances in the field exogenous application of RNA molecules in plants help to protect and modify them through RNA interference (RNAi).
Athanasios Dalakouras, M. Wassenegger, E. Dadami, Ioannis Ganopoulos, M. Pappas, K. Papadopoulou   +5 more
semanticscholar   +1 more source

Using Guided Transfer Learning to Predispose AI Agent to Learn Efficiently from Small RNA-sequencing Datasets [PDF]

arXiv, 2023
Given the increasing availability of RNA-seq data and its complex and heterogeneous nature, there has been growing interest in applying AI/machine learning methodologies to work with such data modalities. However, because omics data is characterized by high dimensionality and low sample size (HDLSS), current attempts at integrating AI in this domain ...
arxiv