Results 121 to 130 of about 74,683 (214)
Cancer Science, EarlyView.Overview of experimental workflow and key findings. Clinically prevalent 2‐hit and 3‐hit PDAC genotypes were first modeled in Drosophila to enable kinome‐wide genetic screening. Candidate therapeutic targets were prioritized using human tumor expression data and pathway enrichment analyses.
Han Hai +10 more
wiley +1 more source
Plant viral suppressors HcPro and P19 inhibit CRISPR-Cas13-mediated transcript interference. [PDF]
Stress BiolSharma VK, Marla S, Cook DE.
europepmc +1 more source
Cancer Science, EarlyView.The proposed mechanistic model in this study. ABSTRACT Noncoding RNAs, including circular RNAs (circRNAs), have been demonstrated to play vital roles in tumorigenesis. Uncovering the functions of circRNAs in tumorigenesis and their underlying regulatory mechanisms may suggest new approaches to the development of novel diagnostic and therapeutic ...
Yanfeng Liu, Yanan Gao, Chuanli Zhao
wiley +1 more source
RNA binding by ADARs prevents RNA interference from attacking self-produced dsRNA. [PDF]
Sci AdvGanem NS +12 more
europepmc +1 more source
Clinical &Experimental Ophthalmology, EarlyView.ABSTRACT Background To investigate, for the first time, whether an unconjugated VEGF‐A antisense oligonucleotide (ASO) can inhibit corneal neovascularisation and improve graft survival in a murine high‐risk corneal transplantation model. Methods A suture‐induced corneal neovascularisation model was established in BALB/c mice, followed by high‐risk ...
Wei Zhang +5 more
wiley +1 more source
Paperclip RNAs bypass clathrin mediated endocytosis in insect and fungal cells. [PDF]
PLoS OneAmanat N +5 more
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Targeting CKIP‐1 for Disease Therapy: Cellular Functions, Molecular Networks, and Clinical Potential
Cell Proliferation, EarlyView.CKIP‐1, as a scaffold protein with special structural domains, treats related diseases through multiple emerging targeted technologies.
Xin Huang +4 more
wiley +1 more source
RNA Interference (RNAi) as a Potential Tool for Control of Mycotoxin Contamination in Crop Plants: Concepts and Considerations. [PDF]
Front Plant Sci, 2017 Majumdar R, Rajasekaran K, Cary JW.
europepmc +1 more source
A lipid‐sensitive food choice behavior influences aging outcomes from a longevity‐promoting diet
The FEBS Journal, EarlyView.C. elegans are exposed to a variety of bacteria in their natural environment and must be able to distinguish between beneficial and detrimental food sources. We show that C. elegans exposed to the bacterium from their natural habitat, Methylobacterium, disrupts lipid homeostasis, causing worms to avoid this bacterial species and choose the laboratory ...
Nicole L. Stuhr +4 more
wiley +1 more source
Rescue of pATOM36‐depleted T. brucei by human MTCH1/2 reveals common features of protein insertases
The FEBS Journal, EarlyView.Human MTCH1 and MTCH2 (with an N‐terminal extension) functionally complement the loss of pATOM36 in T. brucei, indicating that these evolutionarily distant proteins recognize a common set of substrates and share fundamental principles of mitochondrial outer membrane protein insertion. Structural analyses reveal a common hydrophilic cavity, supporting a
Stephan Berger +4 more
wiley +1 more source