Results 81 to 90 of about 74,683 (214)

GSK3β drives early diabetic tubulopathy via TFEB‐mediated mitochondrial dysfunction

Interdisciplinary Medicine, EarlyView.
Mitochondrial dysfunction, including mitochondrial biogenesis, mitophagy, dynamics and oxidative stress, occurs in the early stages of diabetic tubulopathy, which precede proteinuria and renal histological changes. GSK3β is a potential novel biomarker for the prediction of diabetic tubulopathy.
Lan Yao, Xianhui Liang, Bingyu Li, Bohan Chen, Xiaoyang Wang, Mei Hong, Qi Feng, Yingjin Qiao, Zhangsuo Liu, Kai Wang, Pei Wang   +10 more
wiley   +1 more source

SERPINB9 Promotes Colorectal Cancer Liver Metastasis and Immunotherapy Resistance: Association With MHC‐I Downregulation and CD8+ T Cell Dysfunction

Medicine Bulletin, EarlyView.
ABSTRACT Background Colorectal cancer liver metastasis (CRLM) is the leading cause of mortality in colorectal cancer (CRC) patients, for which effective treatments remain limited. The mechanisms by which tumor cells evade immune surveillance and escape cytotoxic killing remain poorly understood.
Xin Liu, Wenchen Wang, Hongqian Wang, Yanshen Kuang, Baoqing Jia   +4 more
wiley   +1 more source

Construction of the over-expression vector and the RNAi vector of BnBRI1 gene from Brassica napus L. and its transformation

四川大学学报. 自然科学版, 2016
In order to investigate the effects of BRI1 gene in Brassica napus (BnBRI1), the over-expression vector pFGC5941-BnBRI1 and the BnBRI1 targeted RNA interference (RNAi) expression vector pFGC5941-BnBRI1-Ri were constructed and transferred into Brassica ...
YANG Zhi-Guo, XIE Tian, WANG Hao-Jie, ZHANG Lu, OUYANG Zhong-Ming, WANG Mao-Lin   +5 more
doaj  

Prime editing in neuropsychiatric disorders: From mutation‐specific target selection to clinical translation

Neuroprotection, EarlyView.
Abstract Prime editing, a novel clustered regularly interspaced short palindromic repeats (CRISPR)‐based technology, fuses a reverse transcriptase (RT) to an engineered CRISPR‐associated protein 9 (Cas9) and uses a prime editing guide RNA (pegRNA)‐encoded template.
Tianshan Ji, Yuan Zhang, Jinyi Zhao, Yiping Lu, Chengkun Wang   +4 more
wiley   +1 more source

RNA interference and turnover in plants -a complex partnership

Frontiers in Plant Science
Plants, often exposed to unfavorable external conditions and pathogen attacks, have developed a remarkably complex network of RNA interference (RNAi) pathways.
Michal Krzyszton, Joanna Kufel, Monika Zakrzewska-Placzek   +2 more
doaj   +1 more source

Applications of nanocarrier‐delivered RNA interference in agricultural biological control (2009–2025)

New Plant Protection, EarlyView.
Despite 17 years of development, the effectiveness of nanocarrier‐delivered RNAi pesticide (NDRP) for agricultural biological control remains limited. The successful development of effective NDRP development requires the coordinated optimization of target gene selection and nanocarrier properties, including RNA dosage, multi‐gene targeting, protection ...
Shi Dong Wang, Woo‐Jong Hong, Xu Jiang, Ki‐hong Jung, Yuan Hu Xuan   +4 more
wiley   +1 more source

The Emerging Role of China in the Innovation, Individualization, and Translation of Antiviral Therapeutics for Chronic Hepatitis B

Portal Hypertension &Cirrhosis, EarlyView.
This perspective outlines China's contributions toward functional‐cure‐oriented antiviral therapies for chronic hepatitis B, summarizing key clinical data on bepirovirsen and domestic drug pipelines with balanced coverage of both promising and disappointing trial results.
Dandan Weng, Zhujun Cao, Qing Xie
wiley   +1 more source

Transcriptomic resources and functional validation of RNAi in the cabbage seedpod weevil, Ceutorhynchus obstrictus

Pest Management Science, EarlyView.
Transcriptome sequencing of Ceutorhynchus obstrictus revealed RNA interference (RNAi) targets; double‐stranded RNA microinjection reduced transcript levels and increased mortality, with αCOP and Rop showing strongest lethal effects, indicating promising RNAi‐based pest control candidates.
Apurva Vikas Sabnis, Triin Kallavus, Éricmar Avila Dos Santos, Liina Soonvald, Riina Kaasik, Silva Vilumets, Clauvis Nji Tizi Taning, Kristof De Schutter, Eve Veromann   +8 more
wiley   +1 more source

Nanocarrier-Based Eco-Friendly RNA Pesticides for Sustainable Management of Plant Pathogens and Pests

Nanomaterials
The production of healthy agricultural products has increased the demand for innovative and sustainable plant protection technologies. RNA interference (RNAi), described as post-transcriptional gene silencing, offers great opportunities for developing ...
Heng Qiao, Jingyi Chen, Min Dong, Jie Shen, Shuo Yan   +4 more
doaj   +1 more source

Combined application of Bacillus velezensis JDB15 and Trichoderma harzianum JDL4 suppresses banana Fusarium wilt under controlled conditions

Pest Management Science, EarlyView.
The surfactin C secreted by JDB15 and the probable parasitism of JDL4 lead to the leakage of intracellular macromolecules and the degradation of hyphae, respectively. Combined application of the two strains effectively controls banana Fusarium wilt under controlled conditions.
Deng Chen, Minghao Ju, Hongyang Li, Junting Feng, Xueyong Zi, Xuqian Gong, Yida Che, Xiaoya Lei, Zihuan Geng, Hongsen Deng, Kang Zhao, Jianghui Xie, Xiao‐Lin Chen, Jun Peng   +13 more
wiley   +1 more source