Results 1 to 10 of about 835,495 (286)

The Identification of Two RNA Modification Patterns and Tumor Microenvironment Infiltration Characterization of Lung Adenocarcinoma

Frontiers in Genetics, 2022
Background: RNA modification plays an important role in many diseases. A comprehensive study of tumor microenvironment (TME) characteristics mediated by RNA modification regulators will improve the understanding of TME immune regulation.Methods: We ...
Wan He, Gengpeng Lin, Chaohu Pan, Wenwen Li, Jing Shen, Yangli Liu, Hui Li, Dongfang Wu, Xue-Jia Lin   +8 more
openalex   +3 more sources

RNA Modification in Metabolism. [PDF]

MedComm (2020)
Epigenetic regulation in disease development has been witnessed within this decade. RNA methylation is the predominant form of epigenetic regulation, and the most prevalent modification in RNA is N6‐methyladenosine (m6A).
Liu Y, Sun Z, Gui D, Zhao Y, Xu Y.
europepmc   +2 more sources

GlycoRNA, a novel RNA modification. [PDF]

Discov Oncol
RNA plays a variety of critical roles in cellular environments, including serving as a structural molecule, messenger molecule, translational carrier, and effector molecule.
Hu B, Ma T, Zhou D, Jiao J, Xia X.
europepmc   +2 more sources

RNA modification: a promising code to unravel the puzzle of autoimmune diseases and CD4⁺ T cell differentiation. [PDF]

Front Immunol
Dynamic changes in various forms of RNA modification are critical to the functional homeostasis of the immune system and the pathophysiology of autoimmune diseases. RNA modification-related proteins play an essential role in these processes.
Yu H, Ma Z, Su S, Xu Z, Yi H.
europepmc   +2 more sources

RNA Modification and Its Implication in Plant Pathogenic Fungi [PDF]

The Plant Pathology Journal, 2021
Interaction of a pathogen with its host plant requires both flexibility and rapid shift in gene expression programs in response to environmental cues associated with host cells. Recently, a growing volume of data on the diversity and ubiquity of internal
Junhyun Jeon, Song Hee Lee
doaj   +1 more source

The Dihydrouridine landscape from tRNA to mRNA: a perspective on synthesis, structural impact and function

RNA Biology, 2022
The universal dihydrouridine (D) epitranscriptomic mark results from a reduction of uridine by the Dus family of NADPH-dependent reductases and is typically found within the eponym D-loop of tRNAs.
Olivier Finet, Carlo Yague-Sanz, Florian Marchand, Damien Hermand   +3 more
doaj   +1 more source

Multi-omics analysis and validation of the tumor microenvironment of hepatocellular carcinoma under RNA modification patterns

Mathematical Biosciences and Engineering, 2023
Background: Multiple types of RNA modifications are associated with the prognosis of hepatocellular carcinoma (HCC) patients. However, the overall mediating effect of RNA modifications on the tumor microenvironment (TME) and the prognosis of patients ...
Yuanqian Yao, Jianlin Lv, Guangyao Wang, Xiaohua Hong   +3 more
doaj   +1 more source

Nanopore direct RNA sequencing maps the complexity of Arabidopsis mRNA processing and m6A modification [PDF]

, 2020
Understanding genome organization and gene regulation requires insight into RNA transcription, processing and modification. We adapted nanopore direct RNA sequencing to examine RNA from a wild-type accession of the model plant Arabidopsis thaliana and a ...
Barton, Geoffrey J., Gould, Peter D., Hall, Anthony J. W., Knop, Katarzyna, Mackinnon, Katarzyna, Parker, Matthew T., Schurch, Nicholas J., Sherwood, Anna V., Simpson, Gordon G.   +8 more
core   +3 more sources

Readers of RNA Modification in Cancer and Their Anticancer Inhibitors. [PDF]

Biomolecules
Li F, Li W.
europepmc   +2 more sources

No evidence for age-related differences in mitochondrial RNA quality in the female germline

Reproduction and Fertility, 2022
Mitochondrial quality is implicated as a contributor to declining fertility with aging. We investigated mitochondrial transcripts in oocytes and their associated cumulus cells from mice of different ages using RNA-seq.
Fiona Hartley, Arwa Alageel, Ruth Appeltant, Nicki Gray, Emmanouela Repapi, Dagan Wells, Suzannah A Williams, Joanna Poulton   +7 more
doaj   +1 more source