Results 151 to 160 of about 835,495 (286)

Intercellular Connectivity and Multicellular Bioelectric Oscillations in Nonexcitable Cells: A Biophysical Model

ACS Omega, 2018
Javier Cervera, Salvador Meseguer, Salvador Mafe   +2 more
doaj   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Author response: A genome-phenome association study in native microbiomes identifies a mechanism for cytosine modification in DNA and RNA

, 2021
Weiwei Yang, Yu‐Cheng Lin, William Johnson, Nan Dai, Romualdas Vaisvila, Peter Weigele, Yan‐Jiun Lee, Ivan R. Corrêa, Ira Schildkraut, Laurence Ettwiller   +9 more
openalex   +1 more source

Epitranscriptome: Review of Top 25 Most-Studied RNA Modifications [PDF]

, 2022
Viktoriia A. Arzumanian, Georgii Dolgalev, Ilya Y. Kurbatov, Olga I. Kiseleva, Ekaterina V. Poverennaya   +4 more
openalex   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Comprehensive Analysis of Aberrant m6A RNA Modifications Identifies Prognostic Biomarkers in Non-Small Cell Lung Cancer [PDF]

Yifei Li, Peng Jiao, Donghang Li, Yi Tian, Hexin Li, Gaoyuan Sun, Xiaonan Wu, Xin Nie, Xu Li, Siyuan Xu, Xiaokun Tang, Lili Zhang, Li Wan, Lanxin Zhang, Jiahui Cai, Min Tang, Lin Li   +16 more
openalex   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

A Genome-wide Map of RNA m6A Modification in mouse retina

, 2021
Dongsheng Yan, Guangying Luo, Xiaohong Chen, Weiwei Xu   +3 more
openalex   +1 more source

Prediction of m6A and m5C at single-molecule resolution reveals a cooccurrence of RNA modifications across the transcriptome [PDF]

, 2022
Pablo Acera Mateos, A.J. Sethi, Agin Ravindran, Akanksha Srivastava, K. Woodward, Shafi Mahmud, M. Kanchi, Marco Guarnacci, Jiawei Xu, Zaka Wing-Sze Yuen, You Zhou, A Sneddon, William L. Hamilton, Jian Gao, Lora Starrs, Rippei Hayashi, Vihandha O. Wickramasinghe, Kathi Zarnack, Thomas Preiß, Gaétan Burgio, Nathalie Dehorter, Nikolay E. Shirokikh, Eduardo Eyras   +22 more
openalex   +1 more source

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source