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Instrumental analysis of RNA modifications [PDF]
Critical Reviews in Biochemistry and Molecular Biology, 2021 Organisms from all domains of life invest a substantial amount of energy for the introduction of RNA modifications into nearly all transcripts studied to date. Instrumental analysis of RNA can focus on the modified residues and reveal the function of these epitranscriptomic marks.
Patrick A. Limbach +10 more
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The RNA modification database [PDF]
Nucleic Acids Research, 1996 The RNA modification database provides a comprehensive listing of posttranscriptionally modified nucleosides from all RNAs, and is maintained as an updated version of the initial printed report [Limbach,P.A., Crain,P.F. and McCloskey,J.A. (1994)Nucleic Acids Res. , 22, 2183-2196].
Pamela F. Crain, James A. McCloskey
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Mathematical Biosciences and Engineering, 2023 Background: Multiple types of RNA modifications are associated with the prognosis of hepatocellular carcinoma (HCC) patients. However, the overall mediating effect of RNA modifications on the tumor microenvironment (TME) and the prognosis of patients ...
Yuanqian Yao +3 more
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RNA Biology, 2022 The universal dihydrouridine (D) epitranscriptomic mark results from a reduction of uridine by the Dus family of NADPH-dependent reductases and is typically found within the eponym D-loop of tRNAs.
Olivier Finet +3 more
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Novel Modifications in RNA [PDF]
ACS Chemical Biology, 2011 The past several years have seen numerous reports of new chemical modifications for use in RNA. In addition, in that time period, we have seen the discovery of several previously unknown naturally occurring modifications that impart novel properties on the parent RNAs.
Kelly J. Phelps +2 more
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Detection of RNA modifications [PDF]
RNA Biology, 2010 RNA nucleotide modifications are typically of low abundance and frequently go unnoticed by standard detection methods of molecular biology and cell biology. With a burst of knowledge intruding from such diverse areas as genomics, structural biology, regulation of gene expression and immunology, it becomes increasingly clear that many exciting functions
Jürgen Burhenne +2 more
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RNA modifications in brain tumorigenesis [PDF]
Acta Neuropathologica Communications, 2020 AbstractRNA modifications are emerging as critical regulators in cancer biology, thanks to their ability to influence gene expression and the predominant protein isoforms expressed during cell proliferation, migration, and other pro-oncogenic properties.
Poul H. Sorensen +4 more
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Nanopore direct RNA sequencing maps the complexity of Arabidopsis mRNA processing and m6A modification [PDF]
, 2020 Understanding genome organization and gene regulation requires insight into RNA transcription, processing and modification. We adapted nanopore direct RNA sequencing to examine RNA from a wild-type accession of the model plant Arabidopsis thaliana and a ...
Barton, Geoffrey J. +8 more
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No evidence for age-related differences in mitochondrial RNA quality in the female germline
Reproduction and Fertility, 2022 Mitochondrial quality is implicated as a contributor to declining fertility with aging. We investigated mitochondrial transcripts in oocytes and their associated cumulus cells from mice of different ages using RNA-seq.
Fiona Hartley +7 more
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RNA Modification in Carcinogenesis and Development of Gastric Cancer
Zhongliu Fangzhi Yanjiu, 2023 The occurrence of gastric cancer is closely related to environmental, genetic, and epigenetic factors. Currently, RNA modification is a research frontier and hotspot in the field of epigenetics.
XU Jiawen, WANG Qiang, WANG Shouyu
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