Results 211 to 220 of about 835,495 (286)

Research on RNA modification in disease diagnosis and prognostic biomarkers: current status and challenges. [PDF]

Brief Bioinform
Shi H, Li Z, Zou Q, Yang H.
europepmc   +1 more source

Strategic base modifications refine RNA function and reduce CRISPR–Cas9 off-targets

Kaisong Zhang, Wei Shen, Yunting Zhao, Xinyan Xu, Xingyu Liu, Qianqian Qi, Siqi Huang, Tian Tian, Xiang Zhou   +8 more
openalex   +1 more source

Electrical pulse stimulation reflecting the episodic nature of real‐life exercise modulates metabolic and secretory profile of primary human myotubes

FEBS Open Bio, EarlyView.
Here, we introduced an intermittent electrical stimulation protocol mimicking the episodic nature of real‐life exercise in vitro by alternating low‐ and high‐frequency stimulation. In comparison with widely used continuous stimulation, it enhanced the rate of glucose and fatty acid oxidation, but not the myokine release.
Klára Gabrišová, Tímea Kurdiová, Daria Barkova, Natália Pálešová, Jana Babulicová, Silvia Tyčiaková, Marta Novotová, Mária Balážová, Miroslav Sabo, Václav Pustka, Jozef Ukropec, Barbara Ukropcová   +11 more
wiley   +1 more source

Aberrant NSUN1 activity connects m⁵C-RNA modification to TDP-43 neurotoxicity in ALS/FTD. [PDF]

Life Sci Alliance
Parra-Torres M, Dissanayake K, Gray JA, Langlands AJ, Kucuk R, Gierlinski M, Troakes C, King A, McGurk L.   +8 more
europepmc   +1 more source

Berberine–cinnamic acid co‐crystal effect in ameliorating hyperlipidemia might be regulated through the PI3K/AKT/mTOR/SREBP‐1 signaling pathway

FEBS Open Bio, EarlyView.
Berberine–cinnamic acid co‐crystal (BBR‐CA) inhibits the phosphorylation of the phosphatidylinositol 3‐kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) pathway, suppressing the transfer of pre‐sterol regulatory element‐binding proteins‐1 (SREBP‐1) from the endoplasmic reticulum to the nucleus. This results in a decrease in the expression level of
Wenheng Gao, Yunlong Li, Lihua Chen, Wenshuo Yang, Yong He, Ye Yang, Dengke Yin, Song Tan   +7 more
wiley   +1 more source

N6-methyladenosine RNA modification regulates microglial phagocytosis in the APP/PS1 mouse model of Alzheimer's disease. [PDF]

Genes Immun
Qu X, Lin L, Li Y, Chen Y, Chen Y.
europepmc   +1 more source

N6-methyladenosine RNA base modification regulates NKG2D-dependent and cytotoxic genes expression in natural killer cells [PDF]

Raghda A. Elsabbagh, Ghada Abdelhady, Doris Urlaub, Mina Sandusky, Ola Khorshid, Mohamed Z. Gad, Khaled Abou‐Aisha, Carsten Watzl, Mona Rady   +8 more
openalex   +1 more source

Establishment and optimization of the two‐step induction system for generating primordial germ cell‐like cells from chicken embryonic stem cells

FEBS Open Bio, EarlyView.
This study optimizes a two‐step induction system to generate PGCLCs from chicken ESCs. The induced cells express germline markers and migrate to gonads in ovo, offering a novel approach for avian genetic resource conservation. Primordial germ cells (PGCs) are the progenitor cells of sperm and eggs.
Zeyu Li, XianShuai Xu, GuangZheng Liu, XiaoQian Lv, JiuZhou Song, HongYan Sun, YingJie Niu, QiSheng Zuo, Wei Han, BiChun Li, Kai Jin   +10 more
wiley   +1 more source

An Expanded View of RNA Modification with Carbohydrate-Based Metabolic Probes. [PDF]

JACS Au
Hazemi ME, Geeson MB, Müller FM, Mikutis S, Enright AJ, Bernardes GJL.   +5 more
europepmc   +1 more source

RNA Modifications: A Mechanism that Modulates Gene Expression

, 2010
John Karijolich, Athena Kantartzis, Yi‐Tao Yu   +2 more
openalex   +1 more source