Results 21 to 30 of about 853,838 (334)

Lithium alters expression of RNAs in a type-specific manner in differentiated human neuroblastoma neuronal cultures, including specific genes involved in Alzheimer's disease. [PDF]

, 2019
Lithium (Li) is a medication long-used to treat bipolar disorder. It is currently under investigation for multiple nervous system disorders, including Alzheimer's disease (AD).
Balaraman, Yokesh, Chopra, Nipun, Edenberg, Howard J, Kelsoe, John, Lahiri, Debomoy K, Liu, Yunlong, Maloney, Bryan, Nurnberger, John I   +7 more
core   +3 more sources

The epitranscriptomic writer ALKBH8 drives tolerance and protects mouse lungs from the environmental pollutant naphthalene

Epigenetics, 2020
The epitranscriptomic writer Alkylation Repair Homolog 8 (ALKBH8) is a transfer RNA (tRNA) methyltransferase that modifies the wobble uridine of selenocysteine tRNA to promote the specialized translation of selenoproteins.
Andrea Leonardi, Nataliia Kovalchuk, Lei Yin, Lauren Endres, Sara Evke, Steven Nevins, Samuel Martin, Peter C. Dedon, J. Andres Melendez, Laura Van Winkle, Qing-Yu Zhang, Xinxin Ding, Thomas J. Begley   +12 more
doaj   +1 more source

RNA modification-mediated translational control in immune cells

RNA Biology, 2023
RNA modifications play a vital role in multiple pathways of mRNA metabolism, and translational regulation is essential for immune cells to promptly respond to stimuli and adapt to the microenvironment.
Yujuan Zhang, Weiguo Hu, Hua-Bing Li
doaj   +1 more source

The Identification of Two RNA Modification Patterns and Tumor Microenvironment Infiltration Characterization of Lung Adenocarcinoma

Frontiers in Genetics, 2022
Background: RNA modification plays an important role in many diseases. A comprehensive study of tumor microenvironment (TME) characteristics mediated by RNA modification regulators will improve the understanding of TME immune regulation.Methods: We ...
Wan He, Gengpeng Lin, Chaohu Pan, Chaohu Pan, Chaohu Pan, Wenwen Li, Jing Shen, Yangli Liu, Hui Li, Dongfang Wu, Xuejia Lin, Xuejia Lin   +11 more
doaj   +1 more source

Broad role for YBX1 in defining the small noncoding RNA composition of exosomes. [PDF]

, 2017
RNA is secreted from cells enclosed within extracellular vesicles (EVs). Defining the RNA composition of EVs is challenging due to their coisolation with contaminants, lack of knowledge of the mechanisms of RNA sorting into EVs, and limitations of ...
Lambowitz, Alan M, Nottingham, Ryan M, Qin, Yidan, Schekman, Randy, Shurtleff, Matthew J, Temoche-Diaz, Morayma M, Yao, Jun   +6 more
core   +1 more source

Comprehensive identification of diverse ribosomal RNA modifications by targeted nanopore direct RNA sequencing and JACUSA2

RNA Biology, 2023
Ribosomal RNAs are decorated by numerous post-transcriptional modifications whose exact roles in ribosome biogenesis, function, and human pathophysiology remain largely unknown.
Isabel S. Naarmann-de Vries, Christiane Zorbas, Amina Lemsara, Michael Piechotta, Felix G. M. Ernst, Ludivine Wacheul, Denis L. J. Lafontaine, Christoph Dieterich   +7 more
doaj   +1 more source

Nanoparticle-Induced m⁶A RNA Modification: Detection Methods, Mechanisms and Applications

Nanomaterials, 2022
With the increasing application of nanoparticles (NPs) in medical and consumer applications, it is necessary to ensure their safety. As m6A (N6-methyladenosine) RNA modification is one of the most prevalent RNA modifications involved in many diseases and
Yi Wang, Fengkai Ruan, Zhenghong Zuo, Chengyong He   +3 more
doaj   +1 more source

Broad application of a simple and affordable protocol for isolating plant RNA [PDF]

, 2015
BACKGROUND: Standard molecular biological methods involve the analysis of gene expression in living organisms under diverse environmental and developmental conditions. One of the most direct approaches to quantify gene expression is the isolation of RNA.
Ana Arruabarrena, CD Carpenter, Cyril Zipfel, D Weigel, Daniel Couto, L Oñate-Sánchez, Lena Stransfeld, P Chomczynski, Rosa Lozano-Durán   +8 more
core   +1 more source

microRNA-mediated differential expression of TRMU, GTPBP3 and MTO1 in cell models of mitochondrial-DNA diseases

Scientific Reports, 2017
Mitochondrial diseases due to mutations in the mitochondrial (mt) DNA are heterogeneous in clinical manifestations but usually include OXPHOS dysfunction. Mechanisms by which OXPHOS dysfunction contributes to the disease phenotype invoke, apart from cell
Salvador Meseguer, Olga Boix, Carmen Navarro-González, Magda Villarroya, Rachid Boutoual, Sonia Emperador, Elena García-Arumí, Julio Montoya, M.-Eugenia Armengod   +8 more
doaj   +1 more source

RNA modification by M6A methylation in cardiovascular diseases: Current trends and future directions

Frigid Zone Medicine, 2022
N6-methyladenosine (M6A) is the most common modification in eukaryotic RNAs for the regulation of RNA transcription, processing, splicing, degradation, and translation.
Wang Jinglin, Zha Lingfeng
doaj   +1 more source