Results 211 to 220 of about 774,970 (276)

RNA modifications at the heart of oral inflammation. [PDF]

Mol Ther Nucleic Acids
Guzzi N.
europepmc   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Crosstalk between lactylation and RNA modifications in tumorigenesis: mechanisms and therapeutic implications. [PDF]

Biomark Res
Liu S, Ma Q, Zeng C, Li H, Su J, Song Z, Yan R, Zhao Z, Tian S, Huang W.   +9 more
europepmc   +1 more source

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

Enhanced detection of RNA modifications in Escherichia coli utilizing direct RNA sequencing. [PDF]

Cell Rep Methods
Guo Z, Shao Y, Tan L, Lu B, Deng X, Chen S, Li R.   +6 more
europepmc   +1 more source

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source

Epitranscriptomic alterations induced by environmental toxins: implications for RNA modifications and disease. [PDF]

Genes Environ
Alum EU, Ejemot-Nwadiaro RI, Basajja M, Uti DE, Ugwu OP, Aja PM.   +5 more
europepmc   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

Direct RNA sequencing enables improved transcriptome assessment and tracking of RNA modifications for medical applications. [PDF]

Nucleic Acids Res
Hewel C, Wierczeiko A, Miedema J, Friedrich J, Hofmann F, Weißbach S, Dietrich V, Holthöfer L, Haug V, Mündnich S, Schartel L, Lehmann L, Jensen KL, Diederich S, Sys S, Butto T, Paul NW, Koch J, Lyko F, Kraft F, Russo A, Schweiger S, Lemke EA, Helm M, Linke M, Gerber S.   +25 more
europepmc   +1 more source