Results 221 to 230 of about 520,942 (256)
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EcoSal Plus, 2005
Transfer RNA (tRNA) from all organisms on this planet contains modified nucleosides, which are derivatives of the four major nucleosides. tRNA from Escherichia coli/Salmonella enterica contains 31 different modified nucleosides, which are all, except for one (Queuosine[Q]), synthesized on an oligonucleotide ...
Glenn R, Björk, Tord G, Hagervall
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Transfer RNA (tRNA) from all organisms on this planet contains modified nucleosides, which are derivatives of the four major nucleosides. tRNA from Escherichia coli/Salmonella enterica contains 31 different modified nucleosides, which are all, except for one (Queuosine[Q]), synthesized on an oligonucleotide ...
Glenn R, Björk, Tord G, Hagervall
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Role of RNA modifications in cancer
Nature Reviews Cancer, 2020Specific chemical modifications of biological molecules are an efficient way of regulating molecular function, and a plethora of downstream signalling pathways are influenced by the modification of DNA and proteins. Many of the enzymes responsible for regulating protein and DNA modifications are targets of current cancer therapies.
Tony Kouzarides, Isaia Barbieri
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Heterogeneity of chemical modifications on RNA
Biophysical Reviews, 2023The chemical modifications of RNAs broadly impact almost all cellular events and influence various diseases. The rapid advance of sequencing and other technologies opened the door to global methods for profiling all RNA modifications, namely the "epitranscriptome." The mapping of epitranscriptomes in different cells and tissues unveiled that RNA ...
W. S. Sho Goh, Yi Kuang
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RNA pseudouridine modification in plants
Journal of Experimental Botany, 2023Abstract Pseudouridine is one of the well-known chemical modifications in various RNA species. Current advances to detect pseudouridine show that the pseudouridine landscape is dynamic and affects multiple cellular processes. Although our understanding of this post-transcriptional modification mainly depends on yeast and human models ...
Yanli Niu, Lingyun Liu
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Dynamic RNA modifications in disease
Current Opinion in Genetics & Development, 2014While the presence of 6-methyladenosine (m6A) modifications in mRNA was noted several decades ago, the first enzyme reversing this modification was identified very recently. Today we know of two methyltransferases introducing m6A in mRNA--METTL3 and METTL14--and two demethylases that remove it have been identified-FTO (ALKBH9) and ALKBH5. The conserved
Arne, Klungland, John Arne, Dahl
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The chemical diversity of RNA modifications
Biochemical Journal, 2019Abstract Nucleic acid modifications in DNA and RNA ubiquitously exist among all the three kingdoms of life. This trait significantly broadens the genome diversity and works as an important means of gene transcription regulation. Although mammalian systems have limited types of DNA modifications, over 150 different RNA modification types ...
R. Jordan Ontiveros +2 more
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RNA Modifications in Hematologic Malignancies
2023Chemical modifications on macromolecules such as DNA, RNA and proteins play important roles in almost all biological processes. The revival of RNA modification research began with the discovery of RNA modification machineries, and with the development of better techniques for characterizing and profiling these modifications at the transcriptome-wide ...
Yashu, Li, Wen, Tian, Haojian, Zhang
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Messenger RNA Modifications in Plants
Trends in Plant Science, 2019Over 160 distinct RNA modifications are known and collectively termed the epitranscriptome. Some of these modifications have been discovered in mRNA, uncovering a new layer of gene regulation. Transcriptome-wide mapping of epitranscriptomic codes and the discovery of their writers, erasers, and readers that dynamically install, remove, and interpret ...
Lisha, Shen +3 more
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Advances in the detection of RNA modification
Chemical CommunicationsHerein, a comprehensive overview of state-of-the-art techniques for identifying RNA modifications is presented, including high-throughput sequencing technologies and locus-specific approaches.
Ruiqi Zhao, Xin Fang, Xiaocheng Weng
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