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RNA Modifications Modulate Activation of Innate Toll-Like Receptors [PDF]
Genes, 2019 Self/foreign discrimination by the innate immune system depends on receptors that identify molecular patterns as associated to pathogens. Among others, this group includes endosomal Toll-like receptors, among which Toll-like receptors (TLR) 3, 7, 8, and ...
Tatjana Eigenbrod +2 more
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Epitranscriptome: Review of Top 25 Most-Studied RNA Modifications [PDF]
International Journal of Molecular Sciences, 2022 The alphabet of building blocks for RNA molecules is much larger than the standard four nucleotides. The diversity is achieved by the post-transcriptional biochemical modification of these nucleotides into distinct chemical entities that are structurally
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RNA modifications in hematological malignancies
International Journal of Hematology, 2023RNA modifications play an important role in various cancers including blood cancers by controlling gene expression programs critical for survival, proliferation and differentiation of cancer cells. While hundreds of RNA modifications have been identified, many have not been functionally characterized.
Zhen Jin +3 more
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Role of RNA modifications in cancer
Nature Reviews Cancer, 2020Specific chemical modifications of biological molecules are an efficient way of regulating molecular function, and a plethora of downstream signalling pathways are influenced by the modification of DNA and proteins. Many of the enzymes responsible for regulating protein and DNA modifications are targets of current cancer therapies.
Isaia Barbieri +2 more
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Heterogeneity of chemical modifications on RNA
Biophysical Reviews, 2023The chemical modifications of RNAs broadly impact almost all cellular events and influence various diseases. The rapid advance of sequencing and other technologies opened the door to global methods for profiling all RNA modifications, namely the "epitranscriptome." The mapping of epitranscriptomes in different cells and tissues unveiled that RNA ...
W. S. Sho Goh, Yi Kuang
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Quantification of RNA modifications
Nature Reviews Genetics, 2021A new report introduces xPore, a computational method and statistical framework for the analysis of differential RNA modifications from nanopore direct RNA sequencing data.
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EcoSal Plus, 2005
Transfer RNA (tRNA) from all organisms on this planet contains modified nucleosides, which are derivatives of the four major nucleosides. tRNA from Escherichia coli/Salmonella enterica contains 31 different modified nucleosides, which are all, except for one (Queuosine[Q]), synthesized on an oligonucleotide ...
Glenn R, Björk, Tord G, Hagervall
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Transfer RNA (tRNA) from all organisms on this planet contains modified nucleosides, which are derivatives of the four major nucleosides. tRNA from Escherichia coli/Salmonella enterica contains 31 different modified nucleosides, which are all, except for one (Queuosine[Q]), synthesized on an oligonucleotide ...
Glenn R, Björk, Tord G, Hagervall
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RNA pseudouridine modification in plants
Journal of Experimental Botany, 2023Abstract Pseudouridine is one of the well-known chemical modifications in various RNA species. Current advances to detect pseudouridine show that the pseudouridine landscape is dynamic and affects multiple cellular processes. Although our understanding of this post-transcriptional modification mainly depends on yeast and human models ...
Yanli Niu, Lingyun Liu
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Messenger RNA Modifications in Plants
Trends in Plant Science, 2019Over 160 distinct RNA modifications are known and collectively termed the epitranscriptome. Some of these modifications have been discovered in mRNA, uncovering a new layer of gene regulation. Transcriptome-wide mapping of epitranscriptomic codes and the discovery of their writers, erasers, and readers that dynamically install, remove, and interpret ...
Lisha, Shen +3 more
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Dynamic RNA modifications in disease
Current Opinion in Genetics & Development, 2014While the presence of 6-methyladenosine (m6A) modifications in mRNA was noted several decades ago, the first enzyme reversing this modification was identified very recently. Today we know of two methyltransferases introducing m6A in mRNA--METTL3 and METTL14--and two demethylases that remove it have been identified-FTO (ALKBH9) and ALKBH5. The conserved
Arne, Klungland, John Arne, Dahl
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