Results 241 to 250 of about 503,240 (288)

A Prospective Study of Individuals at Risk of Multiple Sclerosis Informs the Design of Primary Prevention Studies

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective In multiple sclerosis, the optimal time for deploying a therapeutic intervention is before the central nervous system is damaged; given the success of trials treating the earliest stage of MS, the radiologically isolated syndrome, developing primary prevention strategies is an important next challenge.
Amy W. Laitinen, Ceren Tozlu, Tina Roostaei, Fatoumata Diallo, Kaho Onomichi, Jiyeon Son, Zongqi Xia, Philip L. De Jager   +7 more
wiley   +1 more source

Enhanced detection of RNA modifications in Escherichia coli utilizing direct RNA sequencing. [PDF]

Cell Rep Methods
Guo Z, Shao Y, Tan L, Lu B, Deng X, Chen S, Li R.   +6 more
europepmc   +1 more source

Innate Immune Reprogramming Mediated by Endogenous Retroelement Dysregulation Drives Multiple Sclerosis Progression

Annals of Clinical and Translational Neurology, EarlyView.
Epigenetic reprogramming in hematopoietic stem and progenitor cells (HSPCs) and downstream myeloid cells, mediated by H3.3 downregulation and endogenous retroelement (ERE) overexpression, contributes to the progression of multiple sclerosis (MS). ABSTRACT Background Skewed myelopoiesis in the bone marrow has been identified as a key driver of multiple ...
Li‐Mei Xiao, Qiu‐Ping Zhao, Run‐Yun Li, Wei Chen, Huan‐Huan Song, Wan‐Jin Chen, Ying Fu   +6 more
wiley   +1 more source

Direct RNA sequencing enables improved transcriptome assessment and tracking of RNA modifications for medical applications. [PDF]

Nucleic Acids Res
Hewel C, Wierczeiko A, Miedema J, Friedrich J, Hofmann F, Weißbach S, Dietrich V, Holthöfer L, Haug V, Mündnich S, Schartel L, Lehmann L, Jensen KL, Diederich S, Sys S, Butto T, Paul NW, Koch J, Lyko F, Kraft F, Russo A, Schweiger S, Lemke EA, Helm M, Linke M, Gerber S.   +25 more
europepmc   +1 more source

Integrative analysis of adenosine-related RNA modifications defines molecular subtypes of bladder cancer and identifies CES1 as a driver of tumor progression and immunotherapy resistance. [PDF]

BMC Cancer
Huo X, Qi J, Zhu Y, Song H, Han W, Wang S.   +5 more
europepmc   +1 more source

The Epitranscriptomic Landscape of Gastric Cancer Stem Cells: The Emerging Role of m⁶A RNA Modifications. [PDF]

Cancers (Basel)
Pádua D, Mesquita P, Almeida R.
europepmc   +1 more source

Programmable RNA Nanostructures Enable Nanopore Detection of Cotranscriptionally Introduced RNA Modifications. [PDF]

Nano Lett
Mohora I, Patiño Guillén G, Neis K, Valero J, Keyser UF, Bošković F.   +5 more
europepmc   +1 more source

The RMaP challenge of predicting RNA modifications by nanopore sequencing. [PDF]

Commun Chem
Spangenberg J, Mündnich S, Busch A, Pastore S, Wierczeiko A, Goettsch W, Dietrich V, Pryszcz LP, Cruciani S, Novoa EM, Joshi K, Perera R, Di Giorgio S, Arrubarrena P, Tellioglu I, Poon CL, Wan YK, Göke J, Hildebrandt A, Dieterich C, Helm M, Marz M, Gerber S, Alagna N.   +23 more
europepmc   +1 more source

Context-Dependent Roles of RNA Modifications in Stress Responses and Diseases [PDF]

International Journal of Molecular Sciences, 2021
RNA modifications are diverse post-transcriptional modifications that regulate RNA metabolism and gene expression. RNA modifications, and the writers, erasers, and readers that catalyze these modifications, serve as important signaling machineries in ...
Emma Wilkinson, Yan-Hong Cui, Yu-Ying He   +2 more
exaly   +2 more sources

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RNA modifications in cancer

British Journal of Cancer, 2023
Currently, more than 170 modifications have been identified on RNA. Among these RNA modifications, various methylations account for two-thirds of total cases and exist on almost all RNAs. Roles of RNA modifications in cancer are garnering increasing interest. The research on m6A RNA methylation in cancer is in full swing at present.
Qiling Tang, Lvyuan Li, Yumin Wang, Pan Wu, Xiangchan Hou, Jiawei Ouyang, Chunmei Fan, Zheng Li, Fuyan Wang, Can Guo, Ming Zhou, Qianjin Liao, Hui Wang, Bo Xiang, Weihong Jiang, Guiyuan Li, Zhaoyang Zeng, Wei Xiong   +17 more
openaire   +2 more sources