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Sequencing diverse RNA modifications
Nature Methods, 2021Nanopore sequencing enables quantitative profiling of pseudouridine and 2′-O-methylation modifications in native RNAs.
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RNA pseudouridine modification in plants
Journal of Experimental Botany, 2023Abstract Pseudouridine is one of the well-known chemical modifications in various RNA species. Current advances to detect pseudouridine show that the pseudouridine landscape is dynamic and affects multiple cellular processes. Although our understanding of this post-transcriptional modification mainly depends on yeast and human models ...
Yanli Niu, Lingyun Liu
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RNA-Guided RNA Modifications: Biogenesis, Functions, and Applications
Accounts of Chemical Research, 2023Post-transcriptional modifications are ubiquitous in both protein-coding and noncoding RNAs (ncRNAs), playing crucial functional roles in diverse biological processes across all kingdoms of life. These RNA modifications can be achieved through two distinct mechanisms: RNA-independent and RNA-guided (also known as RNA-dependent).
Bin Li, Lianghu Qu, Jianhua Yang
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Messenger RNA Modifications in Plants
Trends in Plant Science, 2019Over 160 distinct RNA modifications are known and collectively termed the epitranscriptome. Some of these modifications have been discovered in mRNA, uncovering a new layer of gene regulation. Transcriptome-wide mapping of epitranscriptomic codes and the discovery of their writers, erasers, and readers that dynamically install, remove, and interpret ...
Lisha, Shen +3 more
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RNA Modifications in Hematologic Malignancies
2023Chemical modifications on macromolecules such as DNA, RNA and proteins play important roles in almost all biological processes. The revival of RNA modification research began with the discovery of RNA modification machineries, and with the development of better techniques for characterizing and profiling these modifications at the transcriptome-wide ...
Yashu, Li, Wen, Tian, Haojian, Zhang
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Dynamic RNA modifications in disease
Current Opinion in Genetics & Development, 2014While the presence of 6-methyladenosine (m6A) modifications in mRNA was noted several decades ago, the first enzyme reversing this modification was identified very recently. Today we know of two methyltransferases introducing m6A in mRNA--METTL3 and METTL14--and two demethylases that remove it have been identified-FTO (ALKBH9) and ALKBH5. The conserved
Arne, Klungland, John Arne, Dahl
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Modifications of aminoglycoside antibiotics targeting RNA
Medicinal Research Reviews, 2006AbstractThe increased awareness of the central role of RNA has led to realization that RNA, as structural and functional information accumulation, is also drug target to small molecular therapy. Aminoglycosides are a group of well‐known antibiotics, which function through binding to specific sites in prokaryotic ribosomal RNA (rRNA) and affecting the ...
Jian, Zhou +3 more
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Chemical Modification of Small Interfering RNA
2011Chemically synthesized siRNAs are widely used for gene silencing. For in vitro applications, stability, delivery, and immunological issues are rarely problematic, but for in vivo applications the situation is different. Limited stability, undesirable pharmacokinetic behaviour, and unanticipated side effects from the immune system call for more careful ...
Bramsen, Jesper Bertram, Kjems, Jørgen
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