Results 71 to 80 of about 5,405 (175)

Transfer RNA pyrophosphorolysis with CTP(ATP):tRNA nucleotidyltransferase. A direct route to tRNAs modified at the 3' terminus.

open access: yesJournal of Biological Chemistry, 1983
The pyrophosphorolysis of tRNA by yeast CTP-(ATP):tRNA nucleotidyltransferase has been studied in an effort to define the behavior of the enzyme and the experimental parameters that lead to net loss of the 3'-terminal nucleotide or to nucleotide exchange.
T A, Francis   +3 more
openaire   +2 more sources

Antibiotic Resistance: A Genetic and Physiological Perspective

open access: yesMedComm, Volume 6, Issue 11, November 2025.
The development of resistance to antimicrobials and their historical progression are depicted in this graphic. It draws attention to important biochemical, physiological, and genetic factors that contribute to AMR, such as the transmission of genes, the development of biofilms, and the inactivation of antibiotics.
Rania G. Elbaiomy   +9 more
wiley   +1 more source

Advances and Strategies in Enhancing mRNA Cancer Vaccines

open access: yesAdvanced Materials, Volume 37, Issue 42, October 23, 2025.
Messenger RNA (mRNA) vaccines offer a powerful approach for cancer immunotherapy, but their clinical impact remains limited by delivery challenges and suboptimal immune activation. This review discusses key biological barriers and design strategies—including structural optimization, immunomodulation, organ targeting delivery, and advanced nanocarriers ...
Miao Zhang   +4 more
wiley   +1 more source

Recognition of the tRNA-like structure in tobacco mosaic viral RNA by ATP/CTP:tRNA nucleotidyltransferases from Escherichia coli and Saccharomyces cerevisiae.

open access: yesJournal of Biological Chemistry, 1990
The 3'-terminal tRNA-like structure of the tobacco mosaic virus RNA interacts with ATP/CTP:tRNA nucleotidyltransferases from Escherichia coli or yeast in much the same manner as do tRNAs. Primary sites of interaction cluster near the 3' end and in the loop proposed to be analogous to the psi-loop of a tRNA.
L A, Hegg, M, Kou, D L, Thurlow
openaire   +2 more sources

EVALUATION OF ANTIBIOTIC RESISTANCE PROFILES OF HALOBACTERIA ISOLATED FROM THE FOOD CHAIN [PDF]

open access: yes, 2017
L’insorgenza e la diffusione dell’antibiotico resistenza sta diventando un problema a livello mondiale. Molti sono gli ambienti in cui può avvenire tale diffusione, ma una delle principali vie di trasmissione passa attraverso la catena alimentare ...
FALASCONI, IRENE
core  

ant(6)-I Genes encoding aminoglycoside O-nucleotidyltransferases are widely spread among Streptomycin resistant strains of Campylobacter jejuni and Campylobacter coli [PDF]

open access: yes, 2018
info:eu-repo/semantics ...
Borge, Carmen   +9 more
core   +3 more sources

Regulation of RNA stability by terminal nucleotidyltransferases [PDF]

open access: yes, 2019
The dysregulation of RNAs has global effects on all cellular pathways. The regulation of RNA metabolism is thus tightly controlled. Terminal RNA nucleotidyltransferases (TENTs) regulate RNA stability and activity through the addition of non-templated nucleotides to the 3′-end.
openaire  

A human mitochondrial poly(A) polymerase mutation reveals the complexities of post-transcriptional mitochondrial gene expression [PDF]

open access: yes, 2017
The p.N478D missense mutation in human mitochondrial poly(A) polymerase (mtPAP) has previously been implicated in a form of spastic ataxia with optic atrophy. In this study, we have investigated fibroblast cell lines established from family members.
Baslé, Arnaud   +17 more
core  

Expanding the Available RNA Labeling Toolbox With CutA Nucleotidyltransferase for Efficient Transcript Labeling with Purine and Pyrimidine Nucleotide Analogs

open access: yesChemBioChem
AbstractRNA labeling is an invaluable tool for investigation of the function and localization of nucleic acids. Labels are commonly incorporated into 3′ end of RNA and the primary enzyme used for this purpose is RNA poly(A) polymerase (PAP), which belongs to the class of terminal nucleotidyltransferases (NTases).
Rafal Tomecki   +5 more
openaire   +4 more sources

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