Results 51 to 60 of about 5,405 (175)

Omics analysis of educated platelets in cancer and benign disease of the pancreas [PDF]

, 2021
Pancreatic ductal adenocarcinoma (PDAC) is traditionally associated with thrombocy-tosis/hypercoagulation and novel insights on platelet-PDAC “dangerous liaisons” are warranted.
Capula M., Frampton A. E., Giovannetti E., Glogovitis I., In 'T Veld S. G. J. G., Jimenez C. R., Kazemier G., Koppers-Lalic D., Le Large T. Y. S., Mantini G., Meijer L. L., Morelli L., Paleckyte R., Pham T. V., Piersma S. R., Wurdinger T.   +15 more
core   +1 more source

Virulence Regulation and Lifestyle Transitions: The Role of c‐di‐GMP and Two‐Component Systems in Erwinia amylovora and Their Evolutionary Context Within Enterobacterales

Molecular Plant Pathology, Volume 27, Issue 2, February 2026.
Erwinia amylovora infects apple blossoms by activating the T3SS, then spreads systemically via amylovoran‐mediated biofilms. Transitions between motile and sessile states are regulated by key two‐component systems and c‐di‐GMP. This review summarises infection biology, virulence factors, regulatory networks and evolutionary insights underlying fire ...
Dhirendra Niroula, Kalyani Bhandari, George W. Sundin, Janak R. Joshi   +3 more
wiley   +1 more source

Unusual tRNA nucleotidyltransferases: Adaptation of the Romanomermis culicivorax CCA-adding enzyme towards armless tRNAs and characterization of the phosphodiesterase domain of the Escherichia coli CCA-adding enzyme [PDF]

, 2022
tRNAs spielen eine zentrale Rolle in jedem bekannten Organismus. Sie agieren als Adaptoren, um den Code der Nukleinsäuren in eine funktionale Aminosäuresequenz zu übersetzen.
Philipp, Susanne
core   +1 more source

Characterization of Giant Myoviridae With Therapeutic Potential Against Grouper Pathogen, Vibrio alginolyticus

International Journal of Microbiology, Volume 2026, Issue 1, 2026.
Background Vibrio alginolyticus is a gram‐negative bacterium responsible for mass mortality in cultured groupers, leading to significant economic losses in the aquaculture industry. Although preventive measures such as chemical treatments, antibiotics, and pesticides have been employed, these methods have been reported to be toxic to the environment ...
Mohammad Tamrin Mohamad Lal, Rafidah Othman, Elliecpearl Jasca Joning, Gilbert Ringgit, Nor Azman Kasan, Motohiko Sano, Ibnu Bangkit Bioshina Suryadi, Attabik Mukhamad Amrillah, Julian Ransangan, Esha Saini   +9 more
wiley   +1 more source

PPL2 translesion polymerase is essential for the completion of chromosomal DNA replication in the african trypanosome [PDF]

, 2013
Faithful copying of the genome is essential for life. In eukaryotes, a single archaeo-eukaryotic primase (AEP), DNA primase, is required for the initiation and progression of DNA replication.
Aguilera, Aidan J. Doherty, Alsford, Altschul, Brun, Burton, Bétous, Callegari, Callegari, Daigaku, David Horn, Della, di Caprio, Diamant, El-Sayed, Elvers, Frick, Garg, Glover, Glover, Godoy, Heller, Hines, Hines, Hopfner, Iyer, Jansen, Jansen, Jozwiakowski, Karras, Kuchta, Lange, Lao-Sirieix, Lazzaro, Lehmann, Li, Lopes, Lucy Glover, Muzi-Falconi, Passos-Silva, Pitcher, Plosky, Proudfoot, Rastogi, Rey, Rupp, Sale, Sean G. Rudd, Siegel, Stanislaw K. Jozwiakowski, Tiengwe, Tiengwe, Ulrich, van Luenen, Waters, Waters, Woodward   +56 more
core   +4 more sources

Integrative Bioinformatics and Machine Learning Identify Novel Diagnostic Biomarkers and Molecular Mechanisms in Sjögren’s Syndrome

International Journal of Genomics, Volume 2026, Issue 1, 2026.
Background Sjögren’s syndrome (SS) is a chronic autoimmune disorder characterized by significant diagnostic challenges due to nonspecific symptoms and a lack of reliable biomarkers, often resulting in delayed diagnosis and suboptimal patient management.
Hua Xu, Yong Liu, Yuyin Song, Yifan Zheng, Haifeng Jing, Yanfei Gao, Depeng Zhou, Xiang Chi, Jia Chen, Zhengrui Li   +9 more
wiley   +1 more source

Exploring the Potential Mechanism of Umbilical Cord Mesenchymal Stem Cell Therapy for Chronic Atrophic Gastritis Based on Multi‐Omics Technology

Stem Cells International, Volume 2026, Issue 1, 2026.
Background Chronic atrophic gastritis (CAG), a prevalent gastrointestinal disorder, is characterized by gastric mucosal atrophy and increased cancer risk. Mesenchymal stem cells (MSCs) exhibit immunomodulatory, anti‐inflammatory, and tissue‐regenerative properties; however, their therapeutic potential for CAG remains underexplored.
Pengchao Bai, Qichao Liu, Miaomiao Yin, Yan Liu, Jianliang Sui, Saihan Wang, Ruikang Jia, Huiyun Liu, Feiyue Zhao, Alain Chapel   +9 more
wiley   +1 more source

Nuclear Surveillance and Degradation of Hypomodified Initiator tRNA\u3csup\u3eMet\u3c/sup\u3e in \u3cem\u3eS. cerevisiae\u3c/em\u3e [PDF]

, 2004
The tRNA m1A58 methyltransferase is composed of two subunits encoded by the essential genes TRM6 and TRM61 (formerly GCD10 and GCD14). The trm6-504 mutation results in a defective m1A methyltransferase (Mtase) and a temperature-sensitive growth phenotype
Anderson, James T., Hinnebusch, Alan G., Kadaba, Sujatha, Krecic, Annette M., Krueger, Anna, Trice, Tamyra   +5 more
core   +1 more source

Viroids: Survivors from the RNA World? [PDF]

, 2014
Because RNA can be a carrier of genetic information and a biocatalyst, there is a consensus that it emerged before DNA and proteins, which eventually assumed these roles and relegated RNA to intermediate functions.
Flores, Ricardo, Gago, Selma, Sanjuán, Rafael, Serra, Pedro   +3 more
core   +1 more source

Discovery of Three Toxic Proteins of Klebsiella Phage fHe-Kpn01 [PDF]

, 2020
The lytic phage, fHe-Kpn01 was isolated from sewage water using an extended-spectrum beta-lactamase-producing strain of Klebsiella pneumoniae as a host. The genome is 43,329 bp in size and contains direct terminal repeats of 222 bp.
Pajunen, Maria I., Skurnik, Mikael, Spruit, Cindy M., Wan, Xing, Wicklund, Anu   +4 more
core   +3 more sources