Results 31 to 40 of about 5,405 (175)

Mutation in PNPT1 , which Encodes a Polyribonucleotide Nucleotidyltransferase, Impairs RNA Import into Mitochondria and Causes Respiratory-Chain Deficiency [PDF]

The American Journal of Human Genetics, 2012
Multiple-respiratory-chain deficiency represents an important cause of mitochondrial disorders. Hitherto, however, mutations in genes involved in mtDNA maintenance and translation machinery only account for a fraction of cases. Exome sequencing in two siblings, born to consanguineous parents, with severe encephalomyopathy, choreoathetotic movements ...
Vedrenne, Vanessa, Gowher, Ali, de Lonlay, Pascale, Nitschké, Patrick, Serre, Valérie, Boddaert, Nathalie, Altuzarra, Cécilia, Mager-Heckel, Anne-Marie, Chretien, Florence, Entelis, Nina, Munnich, Arnold, Tarassov, Ivan, Rötig, Agnès   +12 more
openaire   +3 more sources

Enzymes involved in DNA ligation and end-healing in the radioresistant bacterium [PDF]

, 2007
BACKGROUND: Enzymes involved in DNA metabolic events of the highly radioresistant bacterium Deinococcus radiodurans are currently examined to understand the mechanisms that protect and repair the Deinococcus radiodurans genome after extremely high doses ...
Blasius, M, Buob, R, Hubscher, U, Shevelev, I V   +3 more
core   +3 more sources

Characterization of a Nodavirus Replicase Revealed a de Novo Initiation Mechanism of RNA Synthesis and Terminal Nucleotidyltransferase Activity [PDF]

Journal of Biological Chemistry, 2013
Nodaviruses are a family of positive-stranded RNA viruses with a bipartite genome of RNAs. In nodaviruses, genomic RNA1 encodes protein A, which is recognized as an RNA-dependent RNA polymerase (RdRP) and functions as the sole viral replicase protein responsible for its RNA replication.
Zhaowei, Wang, Yang, Qiu, Yongxiang, Liu, Nan, Qi, Jie, Si, Xiaoling, Xia, Di, Wu, Yuanyang, Hu, Xi, Zhou   +8 more
openaire   +2 more sources

The 3' to 5' exoribonuclease DIS3: from structure and mechanisms to biological functions and role in human disease [PDF]

, 2015
DIS3 is a conserved exoribonuclease and catalytic subunit of the exosome, a protein complex involved in the 3’ to 5’ degradation and processing of both nuclear and cytoplasmic RNA species.
Carazo-Salas, Drach, Kinoshita, Lim, Noguchi, Ohkura, Sazer, Suzuki   +7 more
core   +2 more sources

HOXB1 restored expression promotes apoptosis and differentiation in the HL60 leukemic cell line [PDF]

, 2013
BACKGROUND: Homeobox (HOX) genes deregulation has been largely implicated in the development of human leukemia. Among the HOXB cluster, HOXB1 was silent in a number of analyzed acute myeloid leukemia (AML) primary cells and cell lines, whereas it was ...
Boe, Alessandra, Bottero, Lisabianca, Carè, Alessandra, DE FEO, ALESSANDRA, Errico, Maria C., Felicetti, Federica, Morsilli, Ornella, Petrini, Marina   +7 more
core   +1 more source

Manipulation of mitochondrial poly(A) polymerase family proteins in Trypanosoma brucei impacts mRNA termini processing

Frontiers in Parasitology
RNA-specific nucleotidyltransferases (rNTrs) add nontemplated nucleotides to the 3′ end of RNA. Two noncanonical rNTRs that are thought to be poly(A) polymerases (PAPs) have been identified in the mitochondria of trypanosomes – KPAP1 and KPAP2.
Clara M. Smoniewski, Poorya Mirzavand Borujeni, Marshall Hampton, Austin Petersen, Sean P. Faacks, Reza Salavati, Sara L. Zimmer   +6 more
doaj   +1 more source

Proteome Analysis of Corynebacterium diphtheriae–Macrophage Interaction

PROTEOMICS, EarlyView.
ABSTRACT Contact of Corynebacterium diphtheriae with macrophages induces adaptations on both bacterial and cellular sides. The study presented here was aiming to shed light on the simultaneous intracellular adaptation of the bacteria and changes in the proteome of the phagocytes in response to the internalization of C. diphtheriae.
Luca Musella, Jens Möller, Christopher Lischer, Julio Vera‐Gonzalez, Jörg Hofmann, Lisa Ott, Andreas Burkovski   +6 more
wiley   +1 more source

Ro5‐4864, a ligand of the mitochondrial translocator protein, protects against heart failure in mice via regulation of the p62‐Keap1‐Nrf2 axis

The Journal of Physiology, EarlyView.
Abstract figure legend Graphical abstract of the proposed Ro5‐4864 mechanism of action via p62‐Keap1‐Nrf2 axis in heart failure. TSPO, the 18‐kDa mitochondrial translocator protein of the outer mitochondrial membrane, can directly interact with p62 (also known as SQSTM1), which is crucial for the degradation of damaged mitochondria by autophagy ...
Daphne A. Diloretto, Phung N. Thai, Gabriela Grigorean, Veneese J. Brown, Tjien Dwyer, Nipavan Chiamvimonvat, Elena N. Dedkova, Saul Schaefer   +7 more
wiley   +1 more source

Study of the Aminoglycoside Subsistence Phenotype of Bacteria Residing in the Gut of Humans and Zoo Animals [PDF]

, 2016
Recent studies indicate that next to antibiotic resistance, bacteria are able to subsist on antibiotics as a carbon source. Here we evaluated the potential of gut bacteria from healthy human volunteers and zoo animals to subsist on antibiotics.
Gerrit eBor, Hauke eSmidt, Mark W.J. evan Passel, Mark W.J. evan Passel, Teresita De Jesus eBello Gonzalez, Tina eZuidema   +5 more
core   +3 more sources

Whole‐Genome Sequence Profiling of Listeria innocua From Different Sources: Implications for Public Health

MicrobiologyOpen, Volume 15, Issue 2, April 2026.
The studied strains, LIN_NWU_CNKT and LIN5_NWU_CNKT, exhibit invasiveness, pathogenicity, and MDR profiles. The isolation of these strains from food products and water underscores their significant public health implications, particularly in the context of the “One Health” concept.
Christ‐Donald Kaptchouang Tchatchouang, Daniel Jesuwenu Ajose, Giulia Amagliani, Collins Njie Ateba   +3 more
wiley   +1 more source