Results 41 to 50 of about 4,731 (160)

Biochemical Engineering Perspective on cGAS: From Enzyme Discovery to Potential Industrial Application

ChemBioChem, Volume 27, Issue 5, 13 March 2026.
This review examines the structural and enzymatic properties of cyclic GMP‐AMP synthase, including substrate promiscuity, homologs, and engineered variants. In addition, it evaluates potential expression systems for large‐scale enzyme production and analyzes reaction and purification strategies for the synthesis of cyclic dinucleotides to connect ...
Makram Fataeri, Katrin Rosenthal
wiley   +1 more source

Small Extracellular Vesicles in Gestational Diabetes Mellitus: Current Landscape and Emerging Diagnostic Horizons

Journal of Extracellular Biology, Volume 5, Issue 3, March 2026.
ABSTRACT Gestational diabetes mellitus (GDM) is a common metabolic disorder of pregnancy associated with significant maternal and neonatal morbidity and mortality. Current diagnostic strategies, particularly the oral glucose tolerance test (OGTT), are limited by late detection, variability in diagnostic criteria, and patient burden, highlighting the ...
Mai Ahmed, Dada Oluwaseyi Temilola, Mushi Matjila, Manogari Chetty   +3 more
wiley   +1 more source

A chloroplastic RNA ligase activity analogous to the bacterial and archaeal 2 '-5 ' RNA ligase

, 2012
[EN] Bacteria and archaea contain a 2'-5' RNA ligase that seals in vitro 2',3'-cyclic phosphodiester and 5'-hydroxyl RNA termini, generating a 2',5'-phosphodiester bond. In our search for an RNA ligase able to circularize the monomeric linear replication
Daròs, José-Antonio, Jorge Marqués, Marques Signes, Jorge, Ricardo Flores, José-Antonio Daròs, Flores Pedauye, Ricardo, Nohales, Maria A., María-Ángeles Nohales, Molina Serrano, Diego, Diego Molina-Serrano   +9 more
core   +1 more source

The potato cyst nematode Globodera pallida overcomes major potato resistance through selection on standing variation at a single locus

New Phytologist, Volume 249, Issue 6, Page 3039-3059, March 2026.
Summary Globodera pallida poses a major threat to potato production, with management strategies primarily relying on genetic resistance. However, increasing virulence in field populations across Western Europe raises major concerns for G. pallida control.
Arno S. Schaveling, Dennie M. te Molder, Paul Heeres, Joris J. M. van Steenbrugge, Stefan J. S. van de Ruitenbeek, Casper C. van Schaik, Sven van den Elsen, Geert Smant, Mark G. Sterken   +8 more
wiley   +1 more source

Virulence Regulation and Lifestyle Transitions: The Role of c‐di‐GMP and Two‐Component Systems in Erwinia amylovora and Their Evolutionary Context Within Enterobacterales

Molecular Plant Pathology, Volume 27, Issue 2, February 2026.
Erwinia amylovora infects apple blossoms by activating the T3SS, then spreads systemically via amylovoran‐mediated biofilms. Transitions between motile and sessile states are regulated by key two‐component systems and c‐di‐GMP. This review summarises infection biology, virulence factors, regulatory networks and evolutionary insights underlying fire ...
Dhirendra Niroula, Kalyani Bhandari, George W. Sundin, Janak R. Joshi   +3 more
wiley   +1 more source

Network Pharmacology‐Based Identification of Potential Targets and Mechanisms of Isoginkgetin in Gastric Cancer

BioMed Research International, Volume 2026, Issue 1, 2026.
Background Isoginkgetin (ISO) is a natural flavonoid with potential anticancer effects. However, the anticancer mechanisms of ISO in gastric cancer remain insufficiently explored. Methods Network pharmacology, TCGA data analysis, and molecular docking were employed to identify potential ISO targets and their involvement in gastric cancer ...
Linen Li, Huiling Zhu, Kun Cao, Hao Chen, Poorani Gurumallesh Prabu   +4 more
wiley   +1 more source

Characterization of Giant Myoviridae With Therapeutic Potential Against Grouper Pathogen, Vibrio alginolyticus

International Journal of Microbiology, Volume 2026, Issue 1, 2026.
Background Vibrio alginolyticus is a gram‐negative bacterium responsible for mass mortality in cultured groupers, leading to significant economic losses in the aquaculture industry. Although preventive measures such as chemical treatments, antibiotics, and pesticides have been employed, these methods have been reported to be toxic to the environment ...
Mohammad Tamrin Mohamad Lal, Rafidah Othman, Elliecpearl Jasca Joning, Gilbert Ringgit, Nor Azman Kasan, Motohiko Sano, Ibnu Bangkit Bioshina Suryadi, Attabik Mukhamad Amrillah, Julian Ransangan, Esha Saini   +9 more
wiley   +1 more source

The cytoplasmic poly(A) polymerases GLD-2 and GLD-4 promote general gene expression via distinct mechanisms [PDF]

, 2014
Post-transcriptional gene regulation mechanisms decide on cellular mRNA activities. Essential gatekeepers of post-transcriptional mRNA regulation are broadly conserved mRNA-modifying enzymes, such as cytoplasmic poly(A) polymerases (cytoPAPs).
Yeroslaviz, A., Habermann, B., Nousch, M., Eckmann, C.   +3 more
core   +1 more source

Integrative Bioinformatics and Machine Learning Identify Novel Diagnostic Biomarkers and Molecular Mechanisms in Sjögren’s Syndrome

International Journal of Genomics, Volume 2026, Issue 1, 2026.
Background Sjögren’s syndrome (SS) is a chronic autoimmune disorder characterized by significant diagnostic challenges due to nonspecific symptoms and a lack of reliable biomarkers, often resulting in delayed diagnosis and suboptimal patient management.
Hua Xu, Yong Liu, Yuyin Song, Yifan Zheng, Haifeng Jing, Yanfei Gao, Depeng Zhou, Xiang Chi, Jia Chen, Zhengrui Li   +9 more
wiley   +1 more source

Exploring the Potential Mechanism of Umbilical Cord Mesenchymal Stem Cell Therapy for Chronic Atrophic Gastritis Based on Multi‐Omics Technology

Stem Cells International, Volume 2026, Issue 1, 2026.
Background Chronic atrophic gastritis (CAG), a prevalent gastrointestinal disorder, is characterized by gastric mucosal atrophy and increased cancer risk. Mesenchymal stem cells (MSCs) exhibit immunomodulatory, anti‐inflammatory, and tissue‐regenerative properties; however, their therapeutic potential for CAG remains underexplored.
Pengchao Bai, Qichao Liu, Miaomiao Yin, Yan Liu, Jianliang Sui, Saihan Wang, Ruikang Jia, Huiyun Liu, Feiyue Zhao, Alain Chapel   +9 more
wiley   +1 more source